A5046212411- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Renal and related cancers
- Urinary and Genital Oncology Studies
- RNA modifications and cancer
- Ureteral procedures and complications
- Cancer-related molecular mechanisms research
- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Infectious Disease Case Reports and Treatments
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Esophageal Cancer Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Tuberous Sclerosis Complex Research
- Ferroptosis and cancer prognosis
- Lipid metabolism and biosynthesis
- Prostate Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
Sixth Affiliated Hospital of Sun Yat-sen University
2025
Sun Yat-sen University
2025
Sun Yat-sen Memorial Hospital
2025
Children's Hospital of Capital Institute of Pediatrics
2025
Peking University
2015-2024
Peking University First Hospital
2015-2024
People 's Hospital of Jilin Province
2024
Soochow University
2024
First Affiliated Hospital of Soochow University
2024
Eastern Hepatobiliary Surgery Hospital
2023
Abstract Background Studies on biological functions of N6‐methyladenosine (m 6 A) modification in mRNA have sprung up recent years. Previous studies reported m A can determine fate and play a pivotal role tumour development progression. The zinc finger protein 677 (ZNF677) belongs to the family possesses transcription factor activity by binding sequence‐specific DNA. Methods expression ZNF677 its clinicopathological impact were evaluated renal cell carcinoma (RCC) patients. level was...
Objective MiRNAs and lncRNAs are important regulators in the process of skin photoaging. In this study, we investigated expression changes interactions between miR4298 lncKRTAP5-6-3 chronically UVB-damaged human keratinocyte cell line (HaCaT) cells explored miR4298-MAPK/ERK signaling pathway-Cathepsin D-lncKRTAP5-6-3 mechanisms photoaging cells. Methods HaCaT were irradiated with 12 mJ/cm 2 UVB once a day for 7 days. miR-4298 mimics inhibitors transfected into by lipo3000 transfection...
Accurate preoperative evaluation of rectal cancer lung metastases (RCLM) is critical for implementing precise medicine. While artificial intelligence (AI) methods have been successful in detecting liver and lymph node using magnetic resonance (MR) images, research on still limited. Utilizing MR images to classify RCLM could potentially reduce ionizing radiation exposure the costs associated with chest CT patients without metastases. This study aims develop validate a transformer-based deep...
Background There are currently no biomarker-based prediction models for amlodipine therapeutic efficacy in pediatric hypertension. This study aimed to identify potential biomarkers and establish a model predicting primary hypertension (PH). Methods From January 2022 December 2023, 165 children adolescents with PH prescribed were recruited at our department prospective observational study. Patients grouped into Responders Non-responders after one month treatment. The baseline data the two...
Previous reports about laparoscopic total pelvic exenteration (LTPE) are still limited. In the present study, we described our single-center experience of initial 11 cases. Between April 2011 and September 2015, eight males three females diagnosed as malignancies underwent LTPE by same operation team. We retrospectively collected all cases' parameters surgical technique. Thirty-seven patients who received open surgery were also collected. A comparison between was performed to evaluate...
Upper tract urothelial carcinomas (UTUCs) are rare entities that usually diagnosed at advanced stages. Research on UTUC pathobiology and clinical management has been hampered by the lack of models accurately reflecting disease nature diversity. In this study, a modified organoid culture system is used to generate library 25 patient-derived lines retaining histological architectures, marker gene expressions, genomic landscapes, expression profiles their parental tumors. The study demonstrates...
Abstract Background The nucleosome binding protein 1 (HMGN5/NSBP1) is a member of the HMGN family and highly expressed in several kinds cancer. Nevertheless, role NSBP1 clear cell renal carcinoma (ccRCC) remains unclear. This study aimed to confirm oncogenic ccRCC using vitro vivo models explore mechanism by which contributes tumorigenesis. Methods expression was detected tissues from 152 patients immunohistochemistry, examined lines RT-PCR Western blot analysis. cells were transfected RNAi...
We conducted this study to identify gene promoter methylation status and clinical predictors for upper tract urothelial carcinoma (UTUC) patients. Using methylation-sensitive PCR, we examined ten genes in 687 UTUC A methylated of three predict higher tumor stage (T3 T4), five grade (G3) one pN+ were certified study. Nine factors significantly associated with poor cancer-specific survival. Six considered as develop bladder recurrence after surgery. Methylation occurs commonly UTUCs, may...
Previous studies revealed an unclear correlation between the growth rate of renal cell carcinoma (RCC) and tumor grade did not focus on certain histological subtype. This report investigated in clear RCC (ccRCC).We reviewed 60 patients with 61 ccRCC confirmed by delayed surgeries after at least 12 months active surveillance. The linear (LGR), volumetric (VGR), volume doubling time (VDT) were calculated, their correlations clinicopathologic characteristics analyzed.The mean LGR, VGR, VDT 0.86...
In China, upper tract urothelial carcinoma (UTUC) is less prevalent but more malignant in males. This study investigates the prognostic factors and causes of gender-based differences Chinese populations.Between 1999 2011, 687 UTUC patients who underwent surgery were utilized for this study. We evaluated oncological characteristics, epigenetic biomarkers, cancer-specific survival (CSS), bladder recurrence (BR) rate, contralateral (CUTR) rate. Smoking history, benzene exposure history using...
To describe a novel and pure laparoscopic approach using custom-made bulldog clamp with modified port placement for management of distal ureter during nephroureterectomy.Between October 2013 December 2014, 31 patients found to have upper tract urothelial carcinoma were treated this technique. After finishing standard transperitoneal nephrectomy in 45° 60° recumbent position, an additional 12-mm trocar was inserted at the lower abdomen allow surgeon continue dissecting caudally toward bladder...
Fatty acid synthesis is regulated by transcription factors SREBPs and their escort protein SCAP.Malignant cells become dependent on de novo lipogenesis, which sustains rapid proliferation resistance to cellular stress.Increasing evidence showed SCAP participated in various disease processes including malignant tumors, regulate Tumorigenesis associated with incur glucose consumption lipogenesis.In our study, we discovered that was upregulated BC tissues.SCAP knockdown CRISPR-Cas9 inhibit the...
To investigate the natural history of renal cell carcinoma (RCC) with delayed treatment and to immunohistochemically analyze correlation between some biomarkers growth rate RCC.We reviewed our institutional databases identify tumors which were confirmed be RCC by surgical after at least 12 months active surveillance (AS). Growth was defined as average maximal diameter on computed tomography or magnetic resonance imaging. The clinicopathological characteristics immunohistochemical (Ki-67,...
Abstract:: The kidneys play an irreplaceable role in metabolism and excretion. However, Acute Kidney Injury (AKI) often occurs due to high local concentrations of drugs, inflammation, trauma. Activated optical probes with excellent detection performance can effectively identify biomarkers the initial stage AKI important evaluating preventing development diseases. This article summarizes representative design strategies for molecular special diagnostic applications. These show great potential...