Long noncoding RNAs (lncRNAs) are emerging as important regulators in various biological processes. However, to date, no systematic characterization of lncRNAs has been reported the silkworm Bombyx mori. In present study, we generated eighteen RNA-seq datasets with relatively high depth. Using an in-house designed lncRNA identification pipeline, 11,810 were identified for 5,556 loci. Among these lncRNAs, 474 transcripts intronic (ilncRNAs), 6,250 intergenic (lincRNAs), and 5,086 natural...

This study aimed to investigate multimorbidity patterns and their associated factors among elderly population in China.A total of 10,479 participants aged at least 60 years were drawn from the 2018 wave China Health Retirement Longitudinal Study (CHARLS). Latent class analysis (LCA) was performed identify distinct classes based on 14 self-reported chronic conditions. The multinomial logit model used analyze patterns, focusing individuals' demographic characteristics, socioeconomic status...

LncRNAs and microRNAs can play significant roles in various cancers, including gastric cancer (GC). In our study, we investigated the role of lncRNA XIST GC. We observed that was increased MGC803 BGC823 cells compared to human normal epithelial GES-1 cells. It also shown miR-185 decreased GC cell lines. Silencing inhibit growth bioinformatics analysis performed confirm correlation between miR-185. Interestingly, a negative indicated addition, TGF-β1 predicted as target gene modulate...

Cloud computing, arguably, has become the de facto computing platform for big data processing by researchers and practitioners last decade, enabled different stakeholders to discover valuable information from large scale data. At same time, in we have witnessed fast growing deployment of billions sensors actuators multiple applications domains, such as transportation, manufacturing, connected/wearable health care, smart city so on, stimulating emerging Edge Computing (a.k.a., fog cloudlet)....

Chemotherapy regimens containing cisplatin remain the first-line treatments for patients with oral squamous cell cancer (OSCC); however, treatment effect is often transient because of chemoresistance and recurrence. Understanding mechanisms in OSCC might provide novel targetable vulnerabilities. In present study, we revealed that Forkhead box D1 (FOXD1) upregulated predicted poor prognosis. Moreover, ectopic expression FOXD1 promoted, while silencing inhibited, epithelial-mesenchymal...

Dysregulation of long noncoding RNA (lncRNA) expression contributes to the pathogenesis many human diseases, including liver diseases. Several lncRNAs have been reported play a role in development hepatocellular carcinoma (HCC). However, most studies analyzed only hepatitis B virus (HBV)-related HCC or single group patients regardless viral etiology. To investigate whether are differentially expressed different etiology, we profiled 101 disease-related lncRNAs, 25 previously associated with...

CircPVT1 is demonstrated to promote cancer progression in esophageal squamous cell carcinoma (ESCC). However, the role and potential functional mechanisms of circPVT1 regulating 5-fluorouracil (5-FU) chemosensitivity remain largely unknown.ESCC cells resistant 5-FU were induced with continuous increasing concentrations step-wisely. A counting kit-8 assay was used analyze viability ESCC cells. LDH release kit evaluate cytotoxicity. RT-qPCR assess expression level non-coding RNAs cDNAs....

Objectives To determine the effects of baseline and changes in frailty states on subsequent depressive symptoms, whether sleep duration would modify these effects. Design Prospective, cohort study. Setting The 2011 2013 follow‐up waves China Health Retirement Longitudinal Study (CHARLS). Participants Community‐dwelling old adults who were aged 60 or above at participated CHARLS (N = 5,026). Measurements Frailty was measured using physical phenotype (PFP) scale. Levels symptoms by 10‐item...

Abstract Background Studies on biological functions of N6‐methyladenosine (m 6 A) modification in mRNA have sprung up recent years. Previous studies reported m A can determine fate and play a pivotal role tumour development progression. The zinc finger protein 677 (ZNF677) belongs to the family possesses transcription factor activity by binding sequence‐specific DNA. Methods expression ZNF677 its clinicopathological impact were evaluated renal cell carcinoma (RCC) patients. level was...

Aspergillus niger is a highly versatile fungal strain utilized in industrial production. The expression levels of recombinant genes A. can be enhanced by increasing the copy number. Nevertheless, given prolonged gene editing cycle niger, "one-step" strategy facilitating simultaneous integration into multiple genomic loci would provide definitive advantage. In our previous study, visual multigene system (VMS) was designed to knock out five genes, employing tRNA-sgRNA array that includes...

Abstract Background Frailty, which is defined as aging-related multisystem impairments, can lead to adverse health outcomes. However, evidence for such a connection in Chinese older adults remains lacking. This study examined the association between frailty and future falls disability among community-dwelling adults. Methods Data were obtained from 2011 2015 waves of China Health Retirement Longitudinal Study. Participants aged 60 years above at baseline completed follow-up survey 2015....

Abstract Laryngeal squamous cell carcinoma (LSCC) is a common head and neck cancer. Despite recently improved management of LSCC, chemotherapy resistance patients remains challenge. In this study, we identified that long noncoding RNA FOXD2-AS1 regulates LSCC therapeutic by augmenting stemness. chemotherapy-resistant showed increased expression compared with in chemotherapy-sensitive patients, which predicted poor prognosis. Gain- or loss-of-function experiments upregulated maintained cancer...

Abstract Background Anthocyanins contribute to coloration and antioxidation effects in different plant tissues. MYB transcription factors have been demonstrated be a key regulator for anthocyanin synthesis many plants. However, little information was available about the genes halophyte species Eutrema salsugineum . Result Here we report identification of an important biosynthesis Es MYB90 from , which is tolerant multiple abiotic stresses. Our phylogenetic localization analyses supported...

Background: Cuproptosis has been recognized as a novel regulatory cell death, which confirmed to promote the occurrence and development of tumors. However, whether cuproptosis-related lncRNA an impact on prognosis squamous carcinoma head neck (HNSCC) is still unclear. Methods: In total, 501 HNSCC tumor samples 44 normal were downloaded from TCGA database. Cuproptosis-related lncRNAs obtained by co-expressed analysis. We got prognostic that was associated with cuproptosis using univariate Cox...

Technological innovation is essential to promoting sustainable development in emerging economies as it drives regional coordination and industry upgrading. In order address the understudied connection between industrial structural transformation, this study examines spatial dynamics of technological efficiency (TIE) China’s advanced manufacturing (AMI) along Yangtze River Economic Belt (YREB) from 2007 2022. Through a Data Envelopment Analysis (DEA) Spatial Durbin Model (SDM), we...

It is widely held that organelles inherit from the maternal lineage. However, plastid genome in quite a few angiosperms appears to be biparentally transmitted. unclear how and why biparental inheritance of became activated. Here, we detected widespread occurrence plastids sperm cells (a cellular prerequisite for inheritance) traditional Caprifoliaceae. Of 12 genera sampled, Abelia, Dipelta, Heptacodium, Kolkwitzia, Leycesteria, Linnaea, Lonicera, Symphoricarpos, Triosteum Weigela possessed...

Frailty is a pervasive symptom among the older population, and social participation beneficial factor of late-life well-being. However, studies on bidirectional association between frailty are limited. This study examined cross-sectional lagged associations frailty. The analytic sample contained 6865 community-dwelling adults, with 21,141 observations, from first four waves (2011–2018) China Health Retirement Longitudinal Study (CHARLS). was measured by Index (FI). Social accumulation...

In this review, we focus on the roles of lncRNAs, including cellular and viral in virus replication infected cells. We survey interactions functions several lncRNAs such as XIST, HOTAIR, NEAT1, BIC encoded lncRNAs.

Objectives Previous research has identified that unmet needs are associated with adverse mental health outcomes in older adults. However, the of adults' spousal caregivers unknown. The present study examined association between and depression among caregivers, whether marital satisfaction mediated this association.Methods We included 1,856 participants who provided care to their spouses difficulties activities daily living (ADL) instrumental (IADL) from 2018 China Health Retirement...

Cancer growth is significantly influenced by processes such as pyroptosis, apoptosis, and necroptosis that underlie PANoptosis, a proinflammatory programmed cell death. Several studies have examined the long non-coding RNAs (lncRNAs) associated with pancreatic adenocarcinoma (PAAD). However, predictive value of lncRNAs related to PANoptosis for PAAD has not been established.

Abstract Long noncoding RNAs (lncRNAs) possessed essential functions in the biological behaviors of various human cancers. SLCO4A1 antisense RNA 1 (SLCO4A1‐AS1) is a lncRNA that has been reported as oncogenic regulator colorectal cancer and bladder cancer. However, whether it exerted gene expression cellular processes lung adenocarcinoma (LUAD) remains still obscure. In present research, we unveiled high level SLCO4A1‐AS1 LUAD tissues cells. Moreover, functional assays indicated SLCO4A‐AS1...