A5085354823- Childhood Cancer Survivors' Quality of Life
- Family and Disability Support Research
- Biofield Effects and Biophysics
- Nutrition and Health in Aging
- bioluminescence and chemiluminescence research
- Global Health Care Issues
- Trace Elements in Health
- Family Support in Illness
- Infant Development and Preterm Care
- Photoreceptor and optogenetics research
- Ferroptosis and cancer prognosis
- Frailty in Older Adults
- Acute Kidney Injury Research
- Family and Patient Care in Intensive Care Units
- Intimate Partner and Family Violence
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Chronic Kidney Disease and Diabetes
- Biosensors and Analytical Detection
- Mental Health and Patient Involvement
- Media Studies and Communication
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Biomarkers in Disease Mechanisms
- Vibration Control and Rheological Fluids
- Aging and Gerontology Research
- Gastrointestinal motility and disorders
Fudan University
2023-2025
Chinese University of Hong Kong, Shenzhen
2024
China Shenhua Energy (China)
2023
Kao Yuan University
2023
Sun Yat-sen University
2021-2022
Shanghai Jiao Tong University
2022
Central South University
2021
Hong Kong Baptist University
2021
Hebei Normal University
2018-2021
Shantou University
2021
Despite recent progress in non-small-cell lung cancer (NSCLC) treatment, treatment outcomes remain poor, mainly because of resistance or toxicity. Erastin is a ferroptosis inducer that has shown promising cytotoxic effects various types cancers, including NSCLC. Celastrol triterpene extracted from the Tripterygium wilfordii exhibits potential anticancer activity. However, side celastrol are severe and limit its clinical application. Combination therapy strategy to overcome compensatory...
Background and Purpose Acute kidney injury is a common clinical problem with no definitive or specific treatment. Therefore, the molecular mechanisms of acute must be fully understood to develop novel treatments. Nuciferine, major bioactive compound isolated from lotus leaf, possesses extensive pharmacological activities. Its effect on folic acid‐induced injury, however, remains unknown. Here, we aimed clarify effects nuciferine its action in injury. Experimental Approach The mice were...
Chloride administration has been found to be harmful the kidney in critically ill patients. However association between plasma chloride concentration and renal function never investigated. This was a retrospective study conducted tertiary 24-bed intensive care unit from September 2010 November 2012. Data on serum for each patient during their ICU stay were abstracted electronic database. Cl0 referred initial entry, Clmax, Clmin Clmean maximum, minimum mean values before onset of AKI,...
Abstract Extracellular vesicles (EVs) carry disease‐specific molecular profiles, demonstrating massive potential in biomarker discovery. In this study, we developed an integrated biochip platform, termed EVID‐biochip (EVs identification and detection biochip), which integrates situ electrochemical protein with on‐chip antifouling‐immunomagnetic beads modified CD81 antibodies zwitterion molecules, enabling efficient isolation of neuronal EVs. The capability the to isolate common EVs detect...
Objectives To determine the effects of baseline and changes in frailty states on subsequent depressive symptoms, whether sleep duration would modify these effects. Design Prospective, cohort study. Setting The 2011 2013 follow‐up waves China Health Retirement Longitudinal Study (CHARLS). Participants Community‐dwelling old adults who were aged 60 or above at participated CHARLS (N = 5,026). Measurements Frailty was measured using physical phenotype (PFP) scale. Levels symptoms by 10‐item...
Inflammation quantification through the detection of cytokines and inflammatory factors in a point-of-care scenario is crucial for managing preventing diseases. Achieving early-stage inflammation osteoarthritis (OA), before radiographic findings become apparent, may provide an opportunity accurate diagnosis effective therapy, potentially joint degeneration. Here, we developed glass-fiber-based universal system with CRISPR-Cas12a-based immunosensors (GUSCI) simultaneous multiple biomarkers...
ObjectiveSymptom management is a persistent challenge in pediatric oncology. The WeChat Mini Program, small smartphone application that functions within WeChat, has the potential to assist symptom management. This study aimed develop Program for parents and children with cancer aged 5–17 years old evaluate its usability.MethodsBased on semi-structured interviews of cancer, experts oncology informatics survey children's experience, multidisciplinary research group meetings were conducted...
Delayed luminescence (DL) refers to the photon-induced ultra-weak emitted by samples after light source is switched off. As a noninvasive method for health monitoring and disease diagnosis, DL has attracted increasing attention. The further development of this technology valuable study complex biological processes, such as different growth stages. If studies were be conducted in humans, large numbers subjects all ages would need recruited, individual differences inevitable. budding yeast...
Dose determination in continuous renal replacement therapy (CRRT) is controversial. Most clinical trials use effluent flow rate as a surrogate of the dose. However, such definition may overestimate actually delivered dose due to declining filter function. The current study aimed determine difference between prescribed and clearance its association with transmembrane pressure. Hemofiltration was done mixed pre- postdilution mode. Creatinine concentrations serum fluid were measured...
Lung cancer morbidity and mortality remain the leading causes of tumor-associated death worldwide. The discovery early diagnostic prognostic markers lung could significantly improve survival rate decrease rate. FPN1 is only known mammalian iron exporter. However, molecular biological functions in unclear. Here, mRNA expression was estimated using TCGA, Oncomine, TIMER, UALCAN databases. role evaluated Kaplan-Meier plotter PrognoScan. Associations between immune infiltration were by TIMER...
Abstract Delayed luminescence (DL) is gradually used in various detection of biological systems as a rapid technique, however, its mechanism was still not clear. In this study, new model DL system for liquid samples established to investigate the emission Saccharomyces cerevisiae cells cultured different glucose concentrations. We analyzed relationship between and cell growth, vitality, mitochondrial morphology, DNA (mtDNA) copy number, adenosine triphosphate (ATP), oxygen consumption rate...
To examine the joint effects of self and spousal frailty status on functional mental health in Chinese older adults determine whether such vary by urban versus rural residency.Frailty is a clinical syndrome among old would lead to adverse outcomes. However, studies interactive patterns between spouses outcomes are scarce.Data were from China Health Retirement Longitudinal Study (CHARLS). A total 2,581 married seniors who participated both 2011 2015 waves CHARLS categorised into four groups:...
The current study examined the relationship between napping duration and metabolic syndrome (MetS) among Chinese middle-aged older adults over 4 years. We included 4,526 individuals aged ≥50 years who completed 2011 2015 waves of China Health Retirement Longitudinal Study. General linear models were conducted to analyze association (none, 1 29 minutes, 30 59 60 89 ≥90 minutes) with MetS. At baseline, a higher prevalence MetS was observed participants longer durations (60 minutes or compared...
This study focuses on elder abuse against older adults with mild-to-moderate cognitive and physical impairment who were receiving family care in Chinese context. Specifically, the examined associated factors of discrepancy between caregiver recipient reports committed by caregivers.Many studies identified discrepancies caregivers recipients abuse, but they did not examine contributing to such discrepancies. Various cultural may contribute accuracy reports.A consecutive sample 1,002 their was...
The interaction between Ribonucleic Acids (RNAs) and proteins, also called RNA Protein Interaction (RPI), plays an important role in the life activities of organisms, including various regulatory processes, such as gene splicing, localization, disease pathogenesis. RPI Prediction (RPIP) predicts interactions RNAs which includes looking for existence binding sites interactions, adding RNA-protein functional annotations (such immunity regulation, neuroprotection, etc). Due to huge amounts...
Momentary solitude (the objective state of being alone) has a strong association with negative affective experiences in older people, but little is known about how the role social relationship characteristics on between momentary and affect. We examined affect (NA), whether such was moderated by structural functional aspects relationships. A sample 153 late-middle-aged adults were recruited provided total 6,742 ecological assessment surveys, which solitudes reported for 1,885 (28%) surveys....