A5103045398- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Ferroptosis and cancer prognosis
- Retinal Development and Disorders
- Biochemical and Molecular Research
- Erythropoietin and Anemia Treatment
- RNA regulation and disease
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Cancer-related molecular mechanisms research
- Gene expression and cancer classification
- Pulmonary Hypertension Research and Treatments
- Sirtuins and Resveratrol in Medicine
- Estrogen and related hormone effects
- Tactile and Sensory Interactions
- Menopause: Health Impacts and Treatments
- Neural dynamics and brain function
- Health Literacy and Information Accessibility
- Apelin-related biomedical research
- Macrophage Migration Inhibitory Factor
- Single-cell and spatial transcriptomics
- Renal and related cancers
- Data Stream Mining Techniques
Tongji Hospital
2021-2024
Huazhong University of Science and Technology
2021-2024
Soochow University
2020-2024
First Affiliated Hospital of Soochow University
2020-2024
East China University of Science and Technology
2024
Zhejiang Lab
2024
Tongji University
2020-2023
First Affiliated Hospital of Anhui Medical University
2023
Anhui Medical University
2023
University of Washington
2020-2022
It is currently believed that aging closely linked with mitochondrial dysfunction, and resveratrol exhibits anti-aging neuroprotective effects by improving function, even though the mechanisms are not well defined.This study explored quality (mitochondrial DNA integrity copy number), function (fusion/fission, mitophagy/autophagy), antioxidant system activity of Akt/mTOR Ampk/Sirt1/Pgc1α pathways, inflammation in zebrafish retinas to identify probable resveratrol's effects.mtDNA integrity,...
Abstract Bromodomain and extraterminal domain (BET) family proteins are considered to be epigenetic readers that regulate gene expression by recognizing acetyl lysine residues on histones nonhistone chromatin factors have been classified as curative targets for a variety of cancers. Glioma‐initiating cells (GICs), which commit self‐renewal, perpetual proliferation, multidirectional differentiation, vigorous tumorigenicity, sustain the peculiar genetic diversification in GBM patients, thus,...
Cancer growth is significantly influenced by processes such as pyroptosis, apoptosis, and necroptosis that underlie PANoptosis, a proinflammatory programmed cell death. Several studies have examined the long non-coding RNAs (lncRNAs) associated with pancreatic adenocarcinoma (PAAD). However, predictive value of lncRNAs related to PANoptosis for PAAD has not been established.
Abstract Objectives Formononetin, a phytoestrogen, can improve arterial endothelial cell function by upregulating nitric oxide synthase (eNOS). The estrogen receptor plays an important role in the regulation of eNOS. This study investigated hypothesis that formononetin upregulates eNOS through receptors and MAPK pathways. Methods rat superior mesenteric arteries were cultured with or plus inhibitors for 24 h. isometric tension was measured using myograph system. mRNA protein expression...
Adult human kidneys produce erythropoietin (EPO), which regulates red blood cell formation; however, whether EPO also functions directly on kidney development and controls diabetic disease remains unknown. Here we analyzed the role of in under hyperglycemic conditions zebrafish humans. Diabetic patients respective were enrolled two cohorts. Serum level urine protein change upon administration then analyzed. Transient knockdown permanent knockout EPOR renal TG(WT1B:EGFP) established using...
Clear cell renal carcinoma (ccRCC) is a common tumor type in genitourinary system and has poor prognosis. Ubiquitin dependent modification systems have been reported variety of malignancies influenced genesis progression. However, the molecular characteristics prognostic value ubiquitin ccRCC not systematically reported. In our study, 204 differentially expressed related genes (URGs) were identified from The Cancer Genome Atlas (TCGA) cohort, including 141 up-regulated 63 down-regulated...
There have been no studies as to whether parthanatos, a poly (adenosine diphosphate-ribose) polymerase-1 (PARP-1)-dependent and apoptosis-inducing factor (AIF)-mediated caspase-independent programmed cell death, is present in pulmonary hypertension (PH). Basic have, however, conducted on several of the key molecules such PARP-1, AIF, macrophage migration inhibitory (MIF). For this study, we collected blood samples from 88 incident male patients with PH 50 healthy controls at Shanghai...
Cilia are conserved microtubule-based organelles that function as mechanical and chemical sensors in various cell types. By bioinformatic, genomic, proteomic studies, more than 2000 proteins have been identified cilium-associated or putative ciliary proteins; these referred to the proteome ciliome. However, little is known about of numerous cilia. To identify possible new functional pathways cilia, we carried out a small-scale genetic screen targeting 54 genes by using clustered regularly...
Inclusion body myositis (IBM) is a unique idiopathic inflammatory myopathy with unclear pathogenesis and poor prognosis. Although previous publications have identified some molecular biomarkers, the value of these biomarkers unknown. To identify hub genes signaling pathways related to IBM for understanding IBM-related mechanisms providing guidance therapy development. Two microarray datasets (GSE3112 GSE128470) were downloaded from Gene Expression Omnibus (GEO) database. GEO2R was used...
Abstract A classifier is a software component, often based on Deep Learning, that categorizes each input provided to it into one of fixed set classes. An IDK may additionally output “I Don’t Know” (IDK) for certain inputs. Multiple distinct classifiers be available the same classification problem, offering different trade-offs between effectiveness, i.e. probability successful classification, and efficiency, execution time. Optimal offline algorithms are proposed sequentially ordering such...
This study aims to replicate the phenotype of Ltbp1 knockout mice in zebrafish, and address function LTBP1 craniofacial development.Whole mount situ hybridization (WISH) ltbp1 was performed at critical periods zebrafish development explore spatial-temporal expression pattern. Furthermore, we generated morpholino based knockdown model phenotype.WISH mainly detected mandibular jaw region, brain trunk, internal organs such as pancreas gallbladder. And colocalized with both sox9a ckma region....
The role of microRNAs (miRNAs) in the pathogenesis systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) remains to be fully elucidated. This study evaluated expression profile miRNAs lung tissue patients with SSc-PAH.Lung samples were collected from 3 SSc-PAH and 4 healthy controls. A small RNA high throughput sequence approach was used for screening differentially expressed samples. Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) validate...
<title>Abstract</title> Parkinson's disease profoundly impacts patients' quality of life, yet public awareness is limited. As social networks reach broad audiences, they are vital platforms for health communication. This study analyzed (PD) topics on China's major network, Weibo, to reveal and concerns. We found became a popular keyword due its association with hand tremors, though this trend may impede comprehensive understanding disease. Through time series analysis, marketing accounts...
Objective: Postoperative anemia is a common complication after major surgery. Our study aims to identify factors that are associated with higher risk of developing postoperative thoracic Methods: We conducted retrospective 465 patients who underwent pulmonary surgery in 2017 Shanghai Pulmonary Hospital, China. Of them, 191 standard open thoracotomy (OT), and 274 video-assisted (VATS). A total 350 were diagnosed anemia, 115 did not have anemia. Multiple logistic regression was used compute...
Objective: To summarize the clinical features of leukoencephalopathy with vanishing white matter disease (VWM) in children. Methods: A retrospective cohort study was performed on 54 genetically diagnosed VWM patients Peking University First Hospital from January 2007 to March 2019. Paper registration form and electronic medical record system were used collect data,and children divided into five groups according age onset:<1 year, 1-<2 years, 2-<4 4-<8 years 8-<18 respectively. The...
We report a family with riboflavin-reactive multiple acyl-CoA dehydrogenase deficiency (RR-MADD) partially caused by novel mutation in the electron transfer flavoprotein gene (ETFDH). The RR-MADD was identified physical examination, electromyography, and muscle biopsy of proband. Laboratory examination electromyography suggested disease lipid storage myopathies. This confirmed that revealed deposition fibers. proband’s sister previously had similar disease, so underwent genetic testing....
To evaluate the clinical, pathological, and genetic features of patients with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency (RR-MADD).Thirty-one RR-MADD admitted to our hospital from January 2005 November 2020 were enrolled, their clinical data collected. Pathological characteristics muscle tissue possible pathogenic gene mutations analyzed.The most common in all symmetrical proximal weakness. Laboratory examination revealed elevated levels creatine kinase, homocysteine,...