A5103077882- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- RNA Research and Splicing
- Cytokine Signaling Pathways and Interactions
- Autophagy in Disease and Therapy
- Cardiovascular Health and Risk Factors
- Hereditary Neurological Disorders
- Cellular Mechanics and Interactions
- Neonatal and Maternal Infections
- Cloud Data Security Solutions
- Extracellular vesicles in disease
- interferon and immune responses
- Folate and B Vitamins Research
- Cancer Immunotherapy and Biomarkers
- PI3K/AKT/mTOR signaling in cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Neuroblastoma Research and Treatments
- Trauma and Emergency Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Phytoestrogen effects and research
First Affiliated Hospital of Soochow University
2015-2022
Soochow University
2015-2022
Beijing University of Posts and Telecommunications
2021
Tao Systems (United States)
2020
Army Medical University
2016
Xinqiao Hospital
2016
Chongqing Medical and Pharmaceutical College
2015
Malignant gliomas are the most common primary brain tumors, and molecular mechanisms involving their progression recurrence still largely unclear. Substantial data indicate that oncogene miR-494-3p is significantly elevated in gliomas, but functions of gliomagenesis unknown. The present study aimed to explore role its mechanism human malignant glioma cell lines, cancer stem-like cells. expression level 48 issues 8 normal tissues was determined using stem-loop real-time polymerase chain...
miRNA-184 is an oncogene in human hepatocellular carcinoma but acts as a tumor suppressor tongue squamous cell carcinoma. Studies have shown that miR-184 was down-regulated glioma and TNFα-induced protein 2 (TNFAIP2) closely related to tumorigenesis. This study aimed determine the functions of mechanisms miRNA-184-TNFAIP2 mediated progression.Real-time reverse-transcription PCR detected expression TNFAIP2. U87 U251 cells were transfected with mimic, inhibitor, or negative control miRNA,...
Acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib, is a critical issue for the treatment of EGFR mutant-positive non-small cell lung cancer (NSCLC). Recent evidence supports role microRNA-223 (miR‑223) in modulating chemotherapeutic drug sensitivity, but its EGFR-TKIs NSCLC remains unclear. To this end, we investigated involvement miR‑223 erlotinib resistance, using two pairs TKI-sensitive or resistant lines, PC9...
Glioma has been investigated for decades, but the prognosis remains poor because of rapid proliferation, its aggressive potential, and resistance to chemotherapy or radiotherapy. The mammalian target rapamycin (mTOR) is highly expressed regulates cellular proliferation cell growth. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene transcription translation via up-regulating down-regulating levels miRNAs. This study was conducted explore molecular functions miR-199a-3p in...
Glioblastoma multiforme (GBM) is an intracranial tumor; the feature higher malignant and poorer prognosis. The search for therapeutic targets gliomas has always been a focus of research in field neurology. unusual expression epithelial membrane protein 1 (EMP1) proved most tumors. In our study, we determined level EMP1 glioma tissues. There were levels tissues-particularly GBM tissues-than those normal brain Then discovered that silencing inhibited cell invasion proliferation through...
Abstract Bromodomain and extraterminal domain (BET) family proteins are considered to be epigenetic readers that regulate gene expression by recognizing acetyl lysine residues on histones nonhistone chromatin factors have been classified as curative targets for a variety of cancers. Glioma‐initiating cells (GICs), which commit self‐renewal, perpetual proliferation, multidirectional differentiation, vigorous tumorigenicity, sustain the peculiar genetic diversification in GBM patients, thus,...
Glioma is the most common adult malignant primary brain tumor; however, effect of chemotherapy often limited by drug‑resistance and poor prognosis common. Ring finger protein 138 (RNF138) belongs to E3 ligase family, has significantly higher expression level in glioma tissue than noncancerous tissues. Epithelial-mesenchymal-transition (EMT) a critical role cancer invasion metastasis, ultimately leading increased cell motility resistance genotoxic agents. Extracellular‑signal regulated kinase...
Abstract Background Cancer‐specific autoantibodies found in serum of cancer patients have been characterized as potential predictors the high risk recurrence and treatment response. The objective this study is to investigate clinical utility O‐6‐methylguanine‐DNA methyltransferase (MGMT) novel biomarkers for prediction response glioma through MGMT peptides microarray. Methods A total 201 samples with various WHO grade 311 healthy donors were examined detection by value was studied...
With the widespread development of cloud-native technologies, security system has gradually attracted attention. Cloud-native uses PKI (Public Key Infrastructure) to provide an important guarantee for network security, however heavy certificate management makes mechanism be a bottleneck systems. In constract with PKI, certificateless public key many advantages such as lightness, which is very suitable authentication in environment. However, before introducing into environment, first problem...
Purpose To investigate the clinical performance, pathological characteristics, treatment and prognosis of salivary gland malignant tumor (SGMT) with skull base metastasis.Methods Five SGMT patients metastasis were retrospectively studied. Major symptoms included headache, facial paralysis, ear hearing loss. Three had previous history resection. All underwent preoperative computed tomography (CT) magnetic resonance imaging (MRI). Craniotomy was performed in three patients, all five...