A5100446107- Nanoplatforms for cancer theranostics
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Luminescence and Fluorescent Materials
- Peptidase Inhibition and Analysis
- Advanced Nanomaterials in Catalysis
- Photoacoustic and Ultrasonic Imaging
- Crystallization and Solubility Studies
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- X-ray Diffraction in Crystallography
- Photodynamic Therapy Research Studies
- Antimicrobial Peptides and Activities
- Nanocluster Synthesis and Applications
- Chemical Synthesis and Analysis
- Polydiacetylene-based materials and applications
- Advanced Radiotherapy Techniques
- Ubiquitin and proteasome pathways
- Extracellular vesicles in disease
- Electrochemical sensors and biosensors
- Click Chemistry and Applications
- Molecular Sensors and Ion Detection
- Electrospun Nanofibers in Biomedical Applications
Tianjin University
2020-2025
Shenzhen University
2020-2025
National Center for Nanoscience and Technology
2016-2025
University of Chinese Academy of Sciences
2016-2025
Hebei University of Technology
2018-2025
Ningbo University
2023-2025
Ningbo Institute of Industrial Technology
2020-2025
Chinese Academy of Sciences
2016-2025
Tianjin Medical University
2017-2025
Renmin Hospital of Wuhan University
2020-2025
Organic-inorganic hybrid perovskite (OIHP) photodetectors that simultaneously achieve an ultrafast response and high sensitivity in the near-infrared (NIR) region are prerequisites for expanding current monitoring, imaging, optical communication capbilities. Herein, we demonstrate constructed by OIHP organic bulk heterojunction (BHJ) consisting of a low-bandgap nonfullerene polymer, which broadband spectra up to 1 μm with highest external quantum efficiency approximately 54% at 850 nm, speed...
Merkel cell carcinoma (MCC) is a lethal, virus-associated cancer that lacks effective therapies for advanced disease. Agents blocking the PD-1/PD-L1 pathway have demonstrated objective, durable tumor regressions in patients with solid malignancies and efficacy has been linked to PD-L1 expression microenvironment. To investigate whether MCC might be target blockade, we examined expression, its association tumor-infiltrating lymphocytes (TILs), polyomavirus (MCPyV), overall survival....
An assembly-induced retention effect for enhanced tumor photoacoustic (PA) imaging and therapeutics is described. A responsive small-molecule precursor prepared that simultaneously self-assembles into nanofibers in sites exhibit an effect, which results improved PA signal therapeutic efficacy. This successful proof-of-concept study paves the way to develop novel supramolecular biomaterials cancer diagnostics therapeutics. As a service our authors readers, this journal provides supporting...
The treatment of bacterial infection is one the most challenging tasks in biomedical field. Antibiotics were developed over 70 years and are regarded as efficient type drug to treat infection. However, there a concern that overuse antibiotics can lead growing number multidrug-resistant bacteria. development antibiotic delivery systems improve biodistribution bioavailability practical strategy for reducing generation resistance increasing lifespan newly antibiotics. Here we present an system...
The use of nanoparticles as a potential building block for photosensitizers has recently become focus interest in the field photocatalysis and photodynamic therapy. Porphyrins their derivatives are effective due to extended π-conjugated electronic structure, high molar absorption from visible near-infrared spectrum, singlet oxygen quantum yields well chemical versatility. In this paper, we report synthesis self-assembled porphyrin nanoparticle using zinc meso-tetra(4-pyridyl)porphyrin...
The first example of visible-light-driven reductive carboarylation styrenes with CO2 and aryl halides in a regioselective manner has been achieved. A broad range iodides bromides were compatible this reaction. Moreover, pyridyl halides, alkyl even chlorides also viable method. These findings may stimulate the exploration novel Meerwein arylation-addition reactions user-friendly as radical sources photocatalytic utilization CO2.
On-demand drug release: Magnetothermally responsive drug-encapsulated supramolecular nanoparticles for on-demand release in vivo have been developed. The remote application of an alternative magnetic field heats the particles that effectively trigger drug. An acute concentration can be delivered to tumor vivo, resulting improved therapeutic outcome.
The morphology controlled molecular assemblies play vital roles in biological systems. Here we present endogenous reactive oxygen species (ROS)-triggered transformation of polymer-peptide conjugates (PPCs) for cooperative interaction with mitochondria, exhibiting high tumor therapeutic efficacy. PPCs are composed (i) a β-sheet-forming peptide KLVFF conjugated poly(ethylene glycol) through ROS-cleavable thioketal, (ii) mitochondria-targeting cytotoxic KLAK, and (iii) poly(vinyl alcohol)...
Emerging artificial enzymes with reprogrammed and augmented catalytic activity substrate selectivity have long been pursued sustained efforts. The majority of current candidates rely on noble metals or transition metal oxides rather poor compared natural molecules. To tackle this limitation, we strategically designed a novel enzyme based structurally well-defined Au25 cluster, namely clusterzyme, which is endowed intrinsic high driven by single-atom substitutions modulated bond lengths....
Tumor metastasis is one of the big challenges in cancer treatment and often associated with high patient mortality. Until now, there an agreement that tumor invasion are related to degradation extracellular matrix (ECM) by enzymes. Inspired formation natural ECM situ self-assembly strategy developed our group, herein, we constructed artificial (AECM) based on transformable Laminin (LN)-mimic peptide 1 (BP-KLVFFK-GGDGR-YIGSR) for inhibition metastasis. The was composed three modules including...
Regenerable nanozymes with high catalytic stability and sustainability are promising substitutes for naturally-occurring enzymes but limited by insufficient non-selective activities. Herein, we developed single-atom of RhN
Abstract Achieving the activation of drugs within cellular systems may provide targeted therapies. Here we construct a tumour-selective cascade activatable self-detained system (TCASS) and incorporate imaging probes therapeutics. We show in different mouse models that TCASS accumulates solid tumours. The molecules enhanced accumulation tumour regions via effect recognition induced self-assembly. Analysis molecular penetration tissue shows vivo self-assembly increases capability compared to...
The restoration of tumor suppressor PTEN by synthetic mRNA nanoparticles sensitizes Pten -null or mutated tumors to immune checkpoint blockade therapy.
Abstract Vesicular photothermal therapy agents (PTAs) are highly desirable in (PTT) for their excellent light-harvesting ability and versatile hollow compartments. However, up to now, the reported vesicular PTAs generally self-assembled from small molecules like liposomes, polymer vesicles have seldom been used as due unsatisfactory conversion efficiency resulting irregular packing of chromophores vesicle membranes. Here we report a nano-sized hyperbranched polyporphyrins with favorable...
In cancer treatment, the unsatisfactory solid-tumor penetration of nanomaterials limits their therapeutic efficacy. We employed an in vivo self-assembly strategy and designed polymer–peptide conjugates (PPCs) that underwent acid-induced hydrophobicity increase with a narrow pH-response range (from 7.4 to 6.5). situ tumor microenvironment at appropriate molecular concentrations (around IC50 values PPCs) enabled drug delivery deeper into tumor. A cytotoxic peptide KLAK, decorated pH-sensitive...
As a noninvasive treatment, photodynamic therapy (PDT) is promising strategy against tumors. It based on photosensitizer (PS)-induced phototoxicity after irradiation. However, most clinically approved PSs will be widely distributed in normal tissues, especially the skin, where they induce exposure to light. Therefore, patients must remain dark room for up several weeks during or PDT. Herein, we proposed of aggregation-induced emission (AIE-PSs) entrapped liposomes with controlled...