A5028914059- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Supramolecular Self-Assembly in Materials
- Advanced Sensor and Energy Harvesting Materials
- Advanced biosensing and bioanalysis techniques
- Conducting polymers and applications
- Advanced Nanomaterials in Catalysis
- Peptidase Inhibition and Analysis
- Autophagy in Disease and Therapy
- Silk-based biomaterials and applications
- Advanced Polymer Synthesis and Characterization
- Photoacoustic and Ultrasonic Imaging
- Nanoparticle-Based Drug Delivery
- Polymer Surface Interaction Studies
- Luminescence and Fluorescent Materials
- Graphene and Nanomaterials Applications
- Dendrimers and Hyperbranched Polymers
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Electrochemical sensors and biosensors
- Phagocytosis and Immune Regulation
- Hydrogels: synthesis, properties, applications
- Electrospun Nanofibers in Biomedical Applications
- Advanced Photocatalysis Techniques
- CAR-T cell therapy research
Qingdao University of Science and Technology
2022-2025
National Center for Nanoscience and Technology
2013-2024
University of Chinese Academy of Sciences
2015-2022
Center for NanoScience
2015
An assembly-induced retention effect for enhanced tumor photoacoustic (PA) imaging and therapeutics is described. A responsive small-molecule precursor prepared that simultaneously self-assembles into nanofibers in sites exhibit an effect, which results improved PA signal therapeutic efficacy. This successful proof-of-concept study paves the way to develop novel supramolecular biomaterials cancer diagnostics therapeutics. As a service our authors readers, this journal provides supporting...
A peptide-conjugated poly(β-amino ester) that self-assembles into micelle-like nanoparticles is prepared by a convenient and modular supramolecular approach. The polymer–beclin-1 (P-Bec1) display enhanced cytotoxicity to breast cancer cells through induction of autophagy. This approach overcomes two major limitations the haploinsufficient tumor suppressor Bec1 compared small-molecule drugs: poor delivery tumors owing enzymatic degradation, unstable, non-specific bio-distribution targeting in...
Topological structures of bio-architectonics and bio-interfaces play major roles in maintaining the normal functions organs, tissues, extracellular matrix, cells. In-depth understanding natural self-assembly mechanisms mimicking functional provide us opportunities to artificially control assemblies their biofunctions. Here, we report an intracellular enzyme-catalyzed polymerization approach for efficient synthesis polypeptides situ construction topology-controlled nanostructures. We reveal...
Abstract Layered double hydroxides (LDH) are a class of functional anionic clays that typically consist orthorhombic arrays metal with anions sandwiched between the layers. Due to their unique properties, including high chemical stability, good biocompatibility, controlled drug loading, and enhanced bioavailability, LDHs have many potential applications in medical field. Especially fields bioimaging tumor therapy. This paper reviews research progress nanocomposites field imaging First,...
Autophagy plays a crucial role in the metabolic process. So far, conventional methods are incapable of rapid, precise, and real-time monitoring autophagy living objects. Herein, we describe an situ intracellular self-assembly strategy for quantitative temporal determination objectives. The intelligent building blocks (DPBP) composed by bulky dendrimer as carrier, bis(pyrene) derivative (BP) signal molecule, peptide linker responsive unit that can be cleaved autophagy-specific enzyme, i.e.,...
Cellular immunotherapeutics aim to employ immune cells as anticancer agents. Ex vivo engineering of dendritic (DCs), the initial role an response, benefits tumor elimination by boosting specific antitumor responses. However, directly activating DCs in is less efficient and therefore quite challenging. Here, we designed a nanoactivator that manufactures through autophagy upregulating directly, which lead high-efficiency antigen presention antigen-specific T generation. The significantly...
Smart nanorobots have emerged as novel drug delivery platforms in nanomedicine, potentially improving anti-cancer efficacy and reducing side effects. In this study, an intelligent tumor microenvironment-responsive nanorobot is developed that effectively delivers CpG payloads to Toll-like receptor 9 (TLR9)-positive tumors induce autophagy-mediated cell death for immunotherapy. The are fabricated by co-self-assembly of two amphiphilic triblock polymer peptides: one containing the matrix...
There is an urgent need for efficient and convenient methods to detect SARS-CoV-2 as the global pandemic continues. Currently, detection of COVID-19 relies primarily on reverse transcription PCR (RT-PCR), a laboratory-based method that time-consuming. To tackle this challenge, study proposes immediate high-throughput platform SARS-CoV-2. The uses gold nanoenzymatic colorimetric assay focuses specific 3CLpro in has been extensively characterized stability, sensitivity, range, response time....
Various nanomaterials have been demonstrated as autophagy inducers owing to their endocytosis cell uptake pathway and impairment of lysosomes. pH-dependent drug delivery systems that are capable dissociating in weakly acidic lysosomal environment (pH 4–5) consequently releasing the payloads into cytoplasm paid extensive attention, but autophagy-modulating effects less reported so far. In this study, we report pH-sensitive micelle-like nanoparticles (NPs) self-assembled from poly(β-amino...
Intracellular construction of nanoaggregates from synthetic molecules to mimic natural ordered superstructures has gained increasing attention recently. Here, we develop an endogenous stimuli-induced aggregation (eSIA) approach construct functional for sensing and monitoring cellular physiological processes in situ. We design a series thermosensitive polymer–peptide conjugates (PPCs), which are capable constructing cells based on their isothermal phase transition property. The PPCs composed...
We report a supramolecular approach for preparation of photostable NIR nanovesicles based on cyanine dye derivative as photoacoustic (PA) contrast agent high-performance nano-imaging.
In drug delivery systems, pH-sensitive polymers are commonly used as carriers, and significant efforts have been devoted to the aspects of controlled release drugs. However, few studies address possible autophagic effects on cells. Here, for first time, using a fluorescent autophagy-reporting cell line, this study evaluates autophagy-induced capabilities four types polymeric nanoparticles (NPs) with different physical properties, including size, surface modification, pH-sensitivity. Based...
We report a convenient synthetic approach for one-pot preparation of poly(β-amino ester)s copolymerized with peptides. A family copolymers tertiary amine groups was synthesized by copolymerizing di(ethylene glycol) diacrylate (DEDA), poly(ethylene (PEGDA), 3-(diethylamino)propylamine (DEPA) and GGRGD peptides using the Michael addition reaction. The hydrophobic/hydrophilic properties resulting are adjusted altering feed ratios DEDA PEGDA. self-assembled into nanoparticles sizes around 60–140...
A universal strategy for efficient, mild, and purification-free synthesis in situ screening of functional polymer-peptide nanomaterials is described. More than 1000 polymer–peptide conjugates (PPCs) with various chemical structures, compositions, therapeutic efficacy are created. According to this strategy, the structure–function relationship PPCs revealed, antitumor efficacies top performing evaluated vivo. As a service our authors readers, journal provides supporting information supplied...
Urinary tract infections are typical bacterial which result in a number of economic burdens. With increasing antibiotic resistance, it is urgent that new approaches explored can eliminate pathogenic bacteria without inducing drug resistance. Antimicrobial photodynamic therapy (PDT) promising tactic. It gentle situ photochemical reaction photosensitizer (PS) generates reactive oxygen species (ROS) under laser irradiation. In this work, we have demonstrated Chlorin e6 (Ce6) encapsulated...
Posterior capsule opacification (PCO) is the most common complication after cataract surgery. So far, only method for PCO treatment precisely focused laser However, it causes severe complications such as physical damages and neuron impairments. Here, a nanostructured photothermal ring integrated intraocular lens (Nano-IOLs) reported, in which rim of commercially available IOLs (C-IOLs) decorated with silica coated Au nanorods (Au@SiO2 ), high-efficient prevention The Nano-IOLs capable...