A5100440195- Pancreatic function and diabetes
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Diabetes and associated disorders
- COVID-19 diagnosis using AI
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Tissue Engineering and Regenerative Medicine
- Nanoparticle-Based Drug Delivery
- Mechanical Circulatory Support Devices
- Metabolism, Diabetes, and Cancer
- Cardiomyopathy and Myosin Studies
- Structural Analysis and Optimization
- Additive Manufacturing and 3D Printing Technologies
- Knee injuries and reconstruction techniques
- Pharmacological Effects of Natural Compounds
- Complement system in diseases
- Nerve Injury and Rehabilitation
- Fibroblast Growth Factor Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Traditional Chinese Medicine Analysis
- Orthopaedic implants and arthroplasty
- 3D Printing in Biomedical Research
- Endoplasmic Reticulum Stress and Disease
- MicroRNA in disease regulation
Eastern Hepatobiliary Surgery Hospital
2024
Second Military Medical University
2017-2024
National Clinical Research Center for Digestive Diseases
2023-2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2024
Zhejiang Hospital
2024
Stanford University
2024
Beijing Tian Tan Hospital
2023
Capital Medical University
2023
Southwest University
2022-2023
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2023
To solve the challenge of poor knee repair, an aptamer-bilayer scaffold is designed for autologous mesenchymal stem cell (MSC) recruitment and osteochondral regeneration. The can efficiently recruit MSCs to defect induce directional differentiation MSCs, thus successfully achieving simultaneous regeneration cartilage bone in joint. As a service our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be re-organized online...
Background Whole-cell matrix–assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) has been successfully applied for bacterial identification and typing of many pathogens. The fast reliable qualities MALDI-TOF MS make it suitable clinical diagnostics. the cluster analysis Streptococcus pyogenes, however, not reported. goal our study was to evaluate this approach rapid S. pyogenes. Methods 65 pyogenes isolates were obtained from hospital. samples prepared...
Intracellular redox homeostasis plays an important role in promoting tumor progression, development and even treatment resistance. To this end, balance impairment may become a prospective therapeutic target of cancer. Herein, manganese-based modulator (MHS) is developed for inducing severe reactive oxygen species accumulation glutathione (GSH) deprivation, where such dyshomeostasis brings about dramatic ferroptosis/apoptosis. Tumor-specific degradation manganese oxide nanocarriers...
beta cell failure is a common denominator of diabetes. Susceptibility to stress-induced apoptosis may underlie and/or hamper islet transplantation therapy. The causal basis not well understood. In efforts identify important differences in gene expression alpha vs. cells, termed HIMP1 (Hypoglycemia/hypoxia Inducible Mitochondrial Protein, or HIG1) has been cloned from an cDNA library. It member conserved eukaryote protein family. mice, its two alternatively spliced products each form...
Background Houttuynia cordata Thunb. is an important traditional medical herb in China and other Asian countries, with high medicinal economic value. However, a lack of available genomic information has become limitation for research on this species. Thus, we carried out high-throughput transcriptomic sequencing H. to generate enormous transcriptome sequence dataset gene discovery molecular marker development. Principal Findings Illumina paired-end technology produced over 56 million reads...
In recent years, quantum dots (QDs) have emerged as a potential contrast agent for bioimaging due to their bright luminescence and excellent photostability. However, the wide use of QDs in vivo has been limited underlying toxicity caused by leakage heavy metals. Although non-cadmium developed resolve this issue, comprehensive understanding these newly remains elusive. study, we administered PEGylated copper indium sulfide/zinc sulfide (CuInS2/ZnS), which are typical QDs, analyzed long-term...
Abstract Aims To explore the underlying mechanism by which low‐frequency KRAS mutations result in extensive EndMT occurrence. Methods Exosomes derived from primarily cultured brain arteriovenous malformation (bAVMs) and human umbilical vein endothelial cells (HUVECs) transfected with G12D , WT or NC lentiviruses were isolated, their effects on HUVECs identified western blotting immunofluorescence staining. The expression levels of exosomal microRNAs (miRNAs) evaluated miRNA microarray,...
Abstract Background Surgical resection remains the primary treatment option for gallbladder carcinoma (GBC). However, there is a pressing demand prognostic tools that can refine patients' choices and tailor personalized therapies accordingly. Aims The nomograms were constructed using data of training cohort ( n = 378) GBC patients at Eastern Hepatobiliary Surgery Hospital (EHBH) between 2008 2018. model's performance was validated in 108) Guangzhou Centre from 2007 to Methods results 5‐year...
The essential folding and maturation process of proinsulin in β-cells is largely uncharacterized. To analyze this process, we improved approaches to immunoblotting, metabolic labeling, data analysis used determine the proportion monomers non-monomers changes composition cells. We found natural occurrence a large various non-monomer states, i.e., aggregates, normal mouse human striking increase Ins2(+/Akita) mice response mutation (C96Y) insulin 2 (Ins2) gene. Proinsulin emerges monomer...
The occurrence of non-contiguous, multiple, and remote involvement tuberculous spondylitis is rare. clinical presentation in patients with multifocal musculoskeletal tuberculosis may closely mimic that multiple bone metastases, which makes the accurate diagnosis challenging. Herein, we report a case was misdiagnosed for 8 months as metastases. A 63-year-old male farmer Chinese Han ethnicity presented to us pain left side neck, right chest back 10 without typical symptoms. His past medical...
Pancreatic α and β cells are derived from the same progenitors but play opposing roles in control of glucose homeostasis. Disturbances their function associated with diabetes mellitus. To identify many proteins that define unique pathways differentiation functional features, we have analyzed patterns gene expression αTC1.6 vs. MIN6 cell lines by using oligonucleotide microarrays. Approximately 9–10% >11,000 transcripts examined showed significant differences between two types. Of >700...
Motorcycle crashes have been a significant cause of death and serious injury in urban regions, which has negative effect on the development sustainable transportation. In this study, two logit models, one model for illegal motorcyclist behaviors other crash severity, are developed using motorcycle Hunan Province, China. The models could allow us to simultaneously identify factors related specific severity level crashes. results show that behaviors, including unlicensed riding, drunk improper...
In this study, we evaluated the value of diffusion-weighted imaging (DWI) and magnetic resonance (MR) spectroscopy (MRSI) combined with computed tomography (CT) conventional MR (MRI) in diagnosis Kimura disease (KD). The clinical data CT MRI findings 5 patients KD proven by histopathologic examination were retrospectively reviewed. Diffusion-weighted MRSI performed at 1.5 T 3 KD. Apparent diffusion coefficient (ADC) values choline/creatine ratio lesions compared those contralateral normal...