A5039230721- Hedgehog Signaling Pathway Studies
- Developmental Biology and Gene Regulation
- Connective Tissue Growth Factor Research
- TGF-β signaling in diseases
- Fibroblast Growth Factor Research
- Sulfur Compounds in Biology
- Signaling Pathways in Disease
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- Pluripotent Stem Cells Research
- Embedded Systems and FPGA Design
- RNA Research and Splicing
- Methane Hydrates and Related Phenomena
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Natural product bioactivities and synthesis
- Neurogenesis and neuroplasticity mechanisms
- Hydrocarbon exploration and reservoir analysis
- Invertebrate Immune Response Mechanisms
- Silk-based biomaterials and applications
- Wireless Networks and Protocols
- Wnt/β-catenin signaling in development and cancer
- Bioactive natural compounds
- ATP Synthase and ATPases Research
- Image and Object Detection Techniques
Peter MacCallum Cancer Centre
2020-2024
The University of Melbourne
2020-2024
Henan University
2019-2023
Chongqing Medical University
2013-2023
Peking University
2018-2023
Peking University First Hospital
2023
XinHua Hospital
2015-2022
Shanghai Jiao Tong University
2022
Hunan University
2018
State Key Laboratory of Chemobiosensing and Chemometrics
2018
The current performance of nature compounds in antitumor field is gradually attracted more and attention, we discovered a active ingredient alizarin possess potent natural reductive NF-κB activity to against pancreatic cancer.However, the preclinical pharmacology therapeutic effect, underlying mechanisms inhibiting cancer are still unclear.After high-throughput screening, this first report that can induce inhibitory effect cells.Alizarin induced cell cycle arrest promoted apoptosis by...
Background/Aims: BMP9 is highly capable of promoting osteogenic differentiation mesenchymal stem cells (MSCs) although the molecular mechanism involved largely unknown. Here, we explored detail role PKA/CREB signaling in BMP9-induced differentiation. Methods: Activation status assessed by nonradioactive assay and Western blot. Using PKA inhibitors a dominant negative protein CREB (A-CREB), investigated effect on Results: We found that promotes activity enhances phosphorylation MSCs. shown to...
Abstract: Oleanolic acid (OA), a naturally occurring triterpenoid, exhibits potential antitumor activity in many tumor cell lines. Gallbladder carcinoma is the most common malignancy of biliary tract, and highly aggressive with an extremely poor prognosis. Unfortunately, effects OA on gallbladder are unknown. In this study, we investigated cancer cells underlying mechanism. The results showed that inhibits proliferation dose-dependent time-dependent manner MTT colony formation assay. A flow...
Nonunion is a serious complication of bone fracture that may occur in any the skeletal system. It occurs when broken fails to heal. Mesenchymal stem cell (MSC)-based tissue engineering technology has been considered an efficient method improve healing rate nonunions. Although previous studies have demonstrated morphogenetic protein 9 (BMP9) highly capable promoting osteogenic differentiation MSCs, mechanisms involved remain largely unclear. In present study, we investigated possible...
Hepatocellular carcinoma (HCC) is a disease with high morbidity, mortality, and low cure rate. Hyaluronic acid (HA) widely adopted in tissue engineering drug delivery. 5-(4-Hydroxyphenyl)-3H-1, 2-dithiol-3-thione (ADT-OH) one of commonly used H2S donors. In our previous study, HA-ADT was designed synthesized via coupling HA ADT-OH. this compared sodium hydrosulfide (NaHS, fast H2S-releasing donor) morpholin-4-ium (4-methoxyphenyl)-morpholin-4-ylsulfanylidenesulfido-λ5-phosphane (GYY4137,...
Although BMP9 is highly capable of promoting osteogenic differentiation mesenchymal stem cell (MSCs), the molecular mechanism involved remains to be fully elucidated. Here, we explore possible involvement and detail role JNKs (c-Jun N-terminal kinases) in BMP9-induced MSCs. It was found that stimulated activation MSCs dramatically inhibited by inhibitor SP600125. Moreover, BMP9-activated Smads signaling decreased SP600125 treatment The effects are reproduced with adenoviruses expressing...
Abstract Dedifferentiation is the reversion of mature cells to a stem cell‐like fate, whereby gene expression programs are altered and genes associated with multipotency (re)expressed. Misexpression factors pathways causes formation ectopic neural (NSCs). Whether dedifferentiated NSCs faithfully produce correct number types progeny, or undergo timely terminal differentiation, has not been assessed. Here, we show that induced via bHLH transcription factor Deadpan (Dpn) fail appropriate...
The importance of the Jun N‐terminal Kinase (JNK) pathway during normal development and tumor invasion has been well documented in Drosophila . Here, this plays important roles epithelial morphogenesis, wound healing, apoptosis, immunity regulation lifespan. However, which downstream molecules facilitate these effects is not very elucidated. In study, data are presented on a serine protease homolog (SPH), scarface These show that under regulatory control JNK both necessary sufficient for its...
The Drosophila Air Sac Primordium (ASP) has emerged as an important structure where cellular, genetic and molecular events responsible for invasive behavior branching morphogenesis can be studied. In this report we present data which demonstrate that a Cathepsin‐L encoded by the gene CP1 in is necessary during ASP development. We find expressed knockdown of results suppression migratory observed further show possibly regulates promoting degradation Basement Membrane. Our provide clues to...
Contemporarily, the artificial way to review X-ray film is a common manner Quality Examination for Weld. However, this has much subjectivity, which may greatly affect detection efficiency and accuracy, especially after doing great deal of repetitive mental work. The automatic welding defect inspection system based on could overcome shortcomings marking. Worldwide researchers have made extensive in-depth research extraction recognition, achieved number effective results. there are still some...
Abstract Fate-restricted cells can acquire stem cell-like properties through dedifferentiation, enabling them to gain the plasticity required for differentiation into multiple lineages. Tumour is prominently observed in brain cancers, where transient cell state changes are linked resistance conventional therapies. In this study, we demonstrate that a sub-population of dedifferentiated tumour neural (NSCs) Drosophila , induced by knockdown prospero ( pros ), generate its own glial niche....
Abstract The final size and function of the adult central nervous system (CNS) is determined by neuronal lineages generated neural stem cells (NSCs) in developing brain. In Drosophila , NSCs called neuroblasts (NBs) reside within a specialised microenvironment glial niche. Here, we explore non-autonomous regulation NB proliferation. We show that lipid droplets (LDs) which niche are closely associated with signalling molecule Hedgehog (Hh). Under physiological conditions, cortex Hh...
Abstract Dedifferentiation is the reversion of differentiated cells to a stem cell like fate, whereby, gene expression program mature altered and genes associated with multipotency are expressed. Appropriate terminal differentiation NSCs essential for restricting overall number neurons produced; in addition, faithful production neuronal subtypes that populate brain important NSC function. Both characteristics specified through temporal patterning driven by successive transcription factors...