A5003599259- Sulfur Compounds in Biology
- Fibroblast Growth Factor Research
- RNA modifications and cancer
- Polyamine Metabolism and Applications
- Cancer, Hypoxia, and Metabolism
- Bacteriophages and microbial interactions
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Plant Virus Research Studies
- Autophagy in Disease and Therapy
- Folate and B Vitamins Research
- Herpesvirus Infections and Treatments
- Hydrogen's biological and therapeutic effects
- Poxvirus research and outbreaks
- RNA Interference and Gene Delivery
- Parkinson's Disease Mechanisms and Treatments
- Immunotherapy and Immune Responses
- Bacillus and Francisella bacterial research
- Mast cells and histamine
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Cancer Research and Treatments
- Eicosanoids and Hypertension Pharmacology
Henan University
2016-2025
Heilongjiang Bayi Agricultural University
2025
Cixian People's Hospital
2024-2025
Zhejiang University of Technology
2025
Sichuan University
2024
Kaifeng University
2022-2024
Soochow University
2024
Minzu University of China
2024
Anyang Institute of Technology
2023
Henan University Huaihe Hospital and Huaihe Clinical Institute
2020-2021
Abstract For a long time, hydrogen sulfide (H 2 S) has been considered toxic compound, but recent studies have found that H S is the third gaseous signaling molecule which plays vital role in physiological and pathological conditions. Currently, large number of shown mediates apoptosis through multiple pathways to participate cancer occurrence development, for example, PI3K/Akt/mTOR MAPK pathways. Therefore, regulation production metabolism mediate apoptotic process cells may improve...
Abstract Receptor-interacting protein kinase 3 (RIPK3), a member of the receptor-interacting (RIPK) family with serine/threonine activity, interacts RIPK1 to generate necrosomes, which trigger caspase-independent programmed necrosis. As vital component RIPK3 plays an indispensable role in necroptosis, is crucial for human life and health. In addition, participates pathological process several infections, aseptic inflammatory diseases, tumors (including tumor-promoting -suppressive...
The mechanisms for the heat-induced osteogenesis are not completely known and thermal regulation of human mesenchymal stem cell (hMSC) differentiation is well studied. In this study, direct effects mild heat shock (HS) on hMSCs into osteoblasts in self-assembling peptide hydrogel tissue culture plates were investigated. isolated from bone marrow seeded conventional (two-dimensional [2D] culture) surface three-dimensional (3D) PuraMatrix (3D culture), followed by 1 h HS at 41°C once a week...
Previous evidence from post-mortem Alzheimer disease (AD) brains and drug (especially rapamycin)-oriented in vitro vivo models implicated an aberrant accumulation of the mammalian target rapamycin (mTor) tangle-bearing neurons AD its role formation abnormally hyperphosphorylated tau. Compelling indicated that sequential molecular events such as synthesis phosphorylation tau can be regulated through p70 S6 kinase, well characterized immediate downstream mTor. In present study, we further...
Abstract: Breast cancer is the most commonly diagnosed and leading cause of deaths in women globally. In 2018, 2.1 million new cases were reported, with 627,000 deaths. Pakistan has highest incidence rate breast among Asian countries: one every nine a lifetime risk being cancer. By reason many misconceptions about etiology disease socioeconomic factors, Pakistani have very low rates early detection diagnose at advance stages fewer chances survival. The key to cure diagnosis. aim current...
Monkeypox is a serious public health issue in tropical and subtropical areas. Antivirals that target monkeypox proteins might lead to more effective efficient therapy. The F13 protein essential for the growth maturation of virus. inhibition be viable therapeutic monkeypox. silico fragment-based drug discovery method developing antivirals may provide novel options. In this study, we generated 800 compounds based on tecovirimat, an FDA-approved efficacious at nanomolar quantities against These...
Hepatocellular carcinoma (HCC) is considered the fifth most prevalent cancer among all types of cancers and has third morbidity value. It frequent duplication time a high recurrence rate. Recently, unique technique used liquid biopsies, which carry many markers; prominent circulating tumor DNA (ctDNA). Varied methods are to investigate ctDNA, including various forms polymerase chain reaction (PCR) [emulsion PCR (ePCR), digital (dPCR), bead, emulsion, amplification, magnetic (BEAMing) PCR]....
Interleukin 25 (IL-25) is involved in the initiation of T helper cell (Th)2–mediated immunopathologies. In this study, we investigated expression IL-25 inflammatory bowel disease (IBD) and its role induction CD4+ T-cell differentiation. Expression inflamed mucosa patients with IBD was determined by quantitative real-time polymerase chain reaction, immunohistochemistry, enzyme-linked immunosorbent assay. The correlation endoscopic activities C-reactive protein evaluated. Peripheral blood...
Neointima formation often occurs in regions where the endothelium has been damaged and transmural interstitial flow is elevated. Vascular smooth muscle cells (SMCs) fibroblasts/myofibroblasts (FBs/MFBs) contribute to intimal thickening by migrating from media adventitia into site of injury. In this study, for first time, direct effects on SMC FB/MFB migration were investigated an vitro three-dimensional system. Collagen I gels used mimic extracellular matrix (ECM) rat aortic SMCs FBs/MFBs....