A5021683203- Liver Disease Diagnosis and Treatment
- Ovarian function and disorders
- Inflammatory Bowel Disease
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Magnetic and transport properties of perovskites and related materials
- Shape Memory Alloy Transformations
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and disorders
- Pancreatic function and diabetes
- Parkinson's Disease Mechanisms and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Diet, Metabolism, and Disease
- Obstructive Sleep Apnea Research
- Gout, Hyperuricemia, Uric Acid
- IL-33, ST2, and ILC Pathways
- Traffic and Road Safety
- Diabetes Management and Education
- Obesity, Physical Activity, Diet
- Immune Cell Function and Interaction
- Nutritional Studies and Diet
- Traffic Prediction and Management Techniques
- Psoriasis: Treatment and Pathogenesis
First Affiliated Hospital of Xiamen University
2016-2025
Shanghai Tenth People's Hospital
2012-2024
Tongji University
2012-2024
National University of Defense Technology
2024
Tianjin Agricultural University
2024
China Electric Power Research Institute
2023
North China Electric Power University
2023
Fujian Medical University
2010-2022
Dazhou Central Hospital
2022
State Key Laboratory of Surface Physics
2019-2022
Abstract Objective To assess the effect of dapagliflozin plus calorie restriction on remission type 2 diabetes. Design Multicentre, double blind, randomised, placebo controlled trial. Setting 16 centres in mainland China from 12 June 2020 to 31 January 2023. Participants 328 patients with diabetes aged 20-70 years, body mass index >25 and duration <6 years. Interventions Calorie 10 mg/day or placebo. Main outcome measures Primary outcome: incidence (defined as glycated haemoglobin...
<h3>Objective</h3> MicroRNA (miR)-301a is known to be involved in the tumourigenesis and pathogenesis of several autoimmune diseases, but it remains unclear whether miR-301a associated with IBD. <h3>Methods</h3> expression was assessed peripheral blood mononuclear cells (PBMC) inflamed mucosa patients IBD by quantitative real-time-PCR. Peripheral CD4+ T were transduced lentivirus-encoding pre-miR-301a (LV-miR-301a) or a reverse complementary sequence (LV-anti-miR-301a), their differentiation...
<h3>Objective</h3> Although both innate and adaptive responses to microbiota have been implicated in the pathogenesis of IBD, it is still largely unknown how they are regulated during intestinal inflammation. In this report, we investigated role microRNA (miR)-10a, a small, non-coding RNA, regulation IBD. <h3>Methods</h3> miR-10a expression was analysed inflamed mucosa IBD patients treated with or without antitumour necrosis factor (anti-TNF) monoclonal antibodies (mAb) (infliximab) by...
Most patients with Parkinson disease (PD) develop both cognitive and motor impairment, biomarkers for progression are urgently needed. Although α-synuclein is altered in cerebrospinal fluid of PD, it not known whether predicts or deterioration. We examined clinical data >300 unmedicated PD who participated the deprenyl tocopherol antioxidative therapy parkinsonism (DATATOP) study, up to 8 years follow-up. Longitudinal measures function were studied before (phase 1) during 2) levodopa...
Abstract Adipocytes are the primary sites for fatty acid storage, but synthesis rate of acids is very low. The physiological significance this phenomenon remains unclear. Here, we show that surplus in adipocytes induces necroptosis and lipodystrophy. Transcriptional activation FASN elevates synthesis, decreases NADPH level increases ROS production, which ultimately leads to adipocyte necroptosis. We identify MED20, a subunit Mediator complex, as negative regulator transcription....
Purpose To centrally assess the safety, efficacy, and 6-year follow-up of recombinant adenovirus-p53 (rAd-p53) combined with radiotherapy (RT) for patients nasopharyngeal carcinoma (NPC). Patients Methods A randomized controlled clinical study on rAd-p53 RT in 42 NPC was compared a control group 40 treated alone. In receiving RT, intratumorally injected once week 8 weeks. Concurrent (70 Gy 35 fractions) given to tumor neck lymph node. tumors were monitored adverse events responses. Results...
Interleukin 25 (IL-25) is involved in the initiation of T helper cell (Th)2–mediated immunopathologies. In this study, we investigated expression IL-25 inflammatory bowel disease (IBD) and its role induction CD4+ T-cell differentiation. Expression inflamed mucosa patients with IBD was determined by quantitative real-time polymerase chain reaction, immunohistochemistry, enzyme-linked immunosorbent assay. The correlation endoscopic activities C-reactive protein evaluated. Peripheral blood...
The development of multi-drug resistance (MDR) represents a major obstacle in the successful treatment cancers. However, factors and mechanisms that lead to MDR cholangiocarcinoma (CCA), chemoresistant bile duct carcinoma with poor prognosis, remain unclear. In this study, we established human CCA cell line QBC939/5-FU. Compared QBC939 cells, rounder shape, higher nuclear-cytoplasmic ratio, shorter cycle, faster growth chemotherapeutics are characteristics QBC939/5-FU cells. P-glycoprotein...
In addition to amyloid-β (Aβ) and tau, α-synuclein, best known for its role in Parkinson's disease (PD), has been suggested be involved cognition pathogenesis of Alzheimer's (AD). We investigate the potential α-synuclein cereb
α-Synuclein (α-syn) is a key protein in Parkinson's disease (PD), and one of its phosphorylated forms, pS129, higher PD patients than healthy controls. However, few studies have examined levels longitudinally collected cerebrospinal fluid (CSF) or preclinical cases. In this study, CSF clinical data were contributed by >300 subjects from three cohorts (the longitudinal DATATOP cohort, large cross-sectional cohort LRRK2 mutation carriers). Consistent with our previous observation that pS129...
<h3>Objective</h3> The dysfunction of immune regulation plays a critical role in the pathogenesis number chronic inflammatory disorders, such as IBD. A close relationship between psychological stress and intestinal inflammation has been noted; underlying mechanism remains elusive. This study aims to elucidate pathological pathway regulatory T cells (Treg), its effect on facilitating inflammation. <h3>Design</h3> restraint model was employed induce mice. functions Tregs were determined by...
We reported earlier that β-cell–specific overexpression of glutathione peroxidase (GPx)-1 significantly ameliorated hyperglycemia in diabetic db/db mice and prevented glucotoxicity-induced deterioration β-cell mass function. have now ascertained whether early treatment Zucker fatty (ZDF) rats with ebselen, an oral GPx mimetic, will prevent deterioration. No other antihyperglycemic was given. Ebselen fasting hyperglycemia, sustained nonfasting insulin levels, lowered glucose HbA1c levels no...
Background The associations of oral contraceptive (OC) use with cardiovascular disease (CVD) and all-cause death remains unclear. We aimed to determine the OC incident CVD death. Methods Results This cohort study included 161 017 women who had no at baseline reported their use. divided into ever never Cox proportional hazard models were used calculate ratios 95% CIs for outcomes Overall, 131 (81.4%) participants baseline. multivariable-adjusted users versus 0.92 (95% CI, 0.86-0.99) death,...
Background : To investigate whether the Chinese lacto‐vegetarian diet has protective effects on metabolic and cardiovascular disease (CVD). Methods One hundred sixty‐nine healthy lacto‐vegetarians 126 omnivore men aged 21–76 years were enrolled. Anthropometric indexes, lipid profile, insulin sensitivity, pancreatic β cell function, intima‐media thickness (IMT) of carotid arteries assessed compared. Cardiovascular risk points probability developing CVD in 5–10 participants 24–55 calculated....
Evidence on the role of irisin in insulin resistance is limited and controversial, pathways between them remain unknown. We aimed to examine independent effects circulating different adiposity measurements, as well their potential interactions, resistance. also explore possible among irisin, adiposity, glucose levels A cross-sectional study 1,115 community- living obese Chinese adults, with data collection clinical characteristics, lipid metabolic parameters levels. Among subjects, 667 (59.8...
The ability to generate and manipulate broadband chiral terahertz waves is essential for applications in material imaging, sensing, diagnosis. It can also open up new possibilities nonlinear spectroscopy coherent control of molecules magnetic materials. existing methods, however, often suffer from low efficiency, narrow bandwidth, or poor flexibility. Here, we propose a novel type laser-driven emitters, consisting metasurface-patterned multilayer heterostructures, that overcome the...
Irisin, an exercise induced myokine, has broad implications for metabolism and energy homeostasis. Available evidence about the association of serum irisin with chronic kidney disease (CKD) is limited. Cross-sectional data on socio-demographic, lifestyle, clinical characteristics were collected 1,115 community-living obese Chinese adults (waist circumference ≥ 90 cm men 80 women). CKD was defined as estimated glomerular filtration rate less than 60 ml/min per 1.73 m2 and/or presence...