A5025391136- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Head and Neck Anomalies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Metabolism, Diabetes, and Cancer
- Thyroid Disorders and Treatments
- Chronic Disease Management Strategies
- Diabetes Management and Education
- Adipose Tissue and Metabolism
- Fibroblast Growth Factor Research
- Obesity, Physical Activity, Diet
- Bone health and treatments
- Kruppel-like factors research
- Epigenetics and DNA Methylation
- Diet, Metabolism, and Disease
- Ovarian cancer diagnosis and treatment
- Eicosanoids and Hypertension Pharmacology
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bone and Dental Protein Studies
- Metabolomics and Mass Spectrometry Studies
- Bariatric Surgery and Outcomes
- Clinical practice guidelines implementation
- Body Composition Measurement Techniques
First Affiliated Hospital of Xiamen University
2015-2024
Xiamen University
2020-2024
Fujian Medical University
2019-2024
Nanjing University of Chinese Medicine
2019
Evidence on the role of irisin in insulin resistance is limited and controversial, pathways between them remain unknown. We aimed to examine independent effects circulating different adiposity measurements, as well their potential interactions, resistance. also explore possible among irisin, adiposity, glucose levels A cross-sectional study 1,115 community- living obese Chinese adults, with data collection clinical characteristics, lipid metabolic parameters levels. Among subjects, 667 (59.8...
Irisin, an exercise induced myokine, has broad implications for metabolism and energy homeostasis. Available evidence about the association of serum irisin with chronic kidney disease (CKD) is limited. Cross-sectional data on socio-demographic, lifestyle, clinical characteristics were collected 1,115 community-living obese Chinese adults (waist circumference ≥ 90 cm men 80 women). CKD was defined as estimated glomerular filtration rate less than 60 ml/min per 1.73 m2 and/or presence...
ObjectiveTo assess the role of neck circumference (NC) in assessing insulin resistance (IR) polycystic ovary syndrome (PCOS).DesignA cross-sectional study.SettingUniversity-affiliated hospital.Patient(s)One hundred forty-three women with PCOS were recruited from November 2018 to February 2020.Intervention(s)None.Main Outcome Measure(s)The associations NC IR and cutoff points for IR.Result(s)The prevalence rates 64.3%. The patients had significantly greater values systolic blood pressure, NC,...
Recent evidence from animal studies indicates that fibroblast growth factor 21 (FGF21), an endocrine hormone regulates glucose, lipid metabolism, and energy homeostasis, is regulated by T3. However, the role of FGF21 in hyperthyroid patients unknown.The objective was to study serum levels association with hyperthyroidism.This a case-control study.A total 119 108 healthy subjects were recruited. Of them, 41 received thionamide treatment for 3 months until euthyroidism obtained.Serum...
Uncontrolled hyperglycemia, hypercholesterolemia, and hypertension are common in persons with diabetes.To compare the effectiveness of team-based care without a clinical decision support system (CDSS) controlling glycemia, lipids, blood pressure (BP) among patients type 2 diabetes.Cluster randomized trial. (ClinicalTrials.gov: NCT02835287).38 community health centers Xiamen, China.11 132 aged 50 years or older uncontrolled diabetes comorbid conditions, 5475 receiving CDSS 5657...
This study aimed to compare the diagnostic performances of six commonly used ultrasound-based risk stratification systems for distinguishing follicular thyroid adenoma (FTA) from carcinoma (FTC), including American Thyroid Association Sonographic Pattern System (ATASPS), ultrasound classification proposed by Clinical Endocrinologists, College Endocrinology, and Associazione Medici Endocrinology (AACE/ACE/AME), Korean imaging reporting data system (K-TIRADS), European (EU-TIRADS), Radiology...
Fibroblast growth factor 21 (FGF21) is identified as a potential biomarker for liver diseases. However, information limited regarding serum FGF21 and impaired function in hyperthyroidism. We aim to determine the association of levels with enzymes hyperthyroid patients. In this case-control study, 105 normal subjects 122 overt patients were included. Among them, 41 who obtained euthyroid status after thionamide treatment received second visit. Serum determined using ELISA method. Compared...
Abstract Purpose The aim of the study is to explore independent association free triiodothyronine (FT3), thyroxine (FT4) and thyroid stimulating hormone (TSH) with hepatic steatosis insulin resistance. Methods A cross-sectional 88 overweight/obese adults who underwent anthropometric measurements [BMI, waist circumference (WC) waist-to-height ratio (WHtR)], assessment (FibroScan) thyroid-related hormones tests was conducted from 2018 2020 in Xiamen, China. Results Subjects increasing tertiles...
Objective Studies have shown that sex differences in lean mass, concentrations of hormones, and lifestyles influence cle health glucose metabolism. We evaluated the sex-specific association between low muscle mass fluctuations hospitalized patients with type 2 diabetes mellitus (T2DM) receiving continuous subcutaneous insulin infusion (CSII) therapy. Methods A total 1084 participants were included. Body composition was determined by dual-energy X-ray absorptiometry. Intraday blood...
Childhood obesity is an important public health problem, which may lead to increased risk of in adulthood. The relationship between the incidence and mode delivery not clear. Cesarean section (CS) be one factors children. We investigated pregnant women overweight/obesity children all ages from 1 4 years.Registered maternal child registration system Xiamen city, newborns born January 2011 December 2012 were followed up years old.9,964 cases included study, 3,462 (34.7%) cesarean deliveries....
Abstract Early short-term intensive insulin (STII) therapy can induce drug-free glycemic remission for up to 1 year in half of newly diagnosed type 2 diabetic mellitus (T2DM) patients. Whether exenatide following STII will higher long-term glycaemic is currently unknown. To assess the effect STII+ therapy, compared with only, on maintenance T2DM In this randomized, parallel-group, open-label, controlled trial, 129 patients (66 group and 63 only group) firstly completed 3-week then was...
Abstract Objective For 1–4 cm differentiated thyroid cancer (DTC), current ATA guideline recommended hemithyroidectomy (HT) as an acceptable alternative initial procedure to total or near‐total thyroidectomy (TT). The aim of this study was evaluate benefits and harms HT, TT in DTC. Design Retrospective cohort study. Patients DTC patients aged 18 years older who underwent a tertiary medical centre were included from January 2008 July 2018. Measurements structural persistent/recurrent disease,...
Rationale: Pycnodysostosis is a rare autosomal recessive skeletal dysplasia caused by mutation in the cathepsin K encoded gene (CTSK). Medullary thyroid carcinoma (MTC) also relatively type of primary carcinoma. Patient concerns: A 31-year-old woman presenting short stature and palpable nodule front her neck that had gradually increased size during last 2 years was referred to our department. She has experienced multiple fractures at lower limbs decades. Diagnoses: The patient's clinical...
Background Childhood obesity is associated with adverse outcomes such as metabolic syndrome, diabetes, and cardiovascular diseases in adulthood. Identifying risk factors related to excessive adiposity early childhood of great importance for intervention. The results studies associations between maternal gestational diabetes offspring are conflicting. Nonetheless, the association glucose across a spectrum values less clear. Aim To assess at age 5 years. Methods A population-based cohort study...
<title>Abstract</title> Purpose Proper management of subcentimeter thyroid nodules remains challenging for both clinicians and patients. Conducting extensive sonographic research using a safe inexpensive tool identifying is necessary. This study aimed to identify whether having highest ultrasound (US) risk characteristic suggests that US-guided fine-needle aspiration (FNA) biopsy in more appropriate the identification malignancy than active surveillance (AS) or surgery. Methods The data...
Proper management of subcentimeter thyroid nodules remains challenging for both clinicians and patients. Conducting extensive sonographic research using a safe inexpensive tool identifying is necessary. The aim this study was to identify whether having the highest-risk ultrasound (US) characteristic suggests that US-guided fine-needle aspiration (FNA) biopsy more appropriate identification malignancy than active surveillance (AS) or surgery.
ABSTRACT Objective Despite the generally favourable long‐term prognosis of low‐risk differentiated thyroid cancer (DTC), questions remain about disease‐free survival (DFS) after initial treatment, particularly regarding use radioactive iodine (RAI). Although there are RCT trial confirming that RAI ablation therapy is not superior to follow‐up in terms 3‐year DFS rate cancer, its longer‐term remains be established. The objective this study was assess impact on presence structural...
Abstract The same thyroid hormone receptor B gene (THRB) mutation led to resistance with different clinical manifestations in the kindreds.
Objectives: Uncontrolled blood glucose, pressure (BP), and low-density lipoprotein cholesterol (LDL-C) are major risk factors for premature death cardiovascular disease (CVD) in patients with diabetes. We compared the effectiveness of team-based care (TBC) clinical decision support systems (CDSS) versus TBC alone on CVD factor control among diabetes China. Methods: In Diabetes Complication Control Community Clinics (D4C) cluster randomized trial, 38 community health centers were randomly...
Objective To study the clinical efficacy of cell block yielded by ultrasound-guided fine needle aspiration in early diagnosis thyroid cancer and differential follicular tumor. Methods Cytological smears were performed 864 nodules aspiration. Then residual specimens made as blocks. Diagnosis was observation organization structure block. Cell sections from 78 with tumors applied to detection immunocytochemical staining for minichromosome maintenance protein(MCM2), growth arrest DNA...
A 30-year-old female with clinical manifestations of palpitations and goiter was admitted to our department endocrinology. Laboratory tests showed elevated thyroid hormone non-suppressed TSH. Genetic analysis identified heterozygous mutation the THRB exon10 c.G1378A (p.E460K). The proband’s kindreds had same mutation, but their were different.
Abstract Purpose: The aim of the study is to explore independent association free triodothyronine (FT3), thyroxine (FT4) and thyroid stimulating hormone (TSH) with hepatic steatosis insulin resistance. Methods : A cross-sectional 88 overweight/obese adults who underwent anthropometric measurements (BMI, waist circumference (WC) waist-to-height ratio (WHtR)), assessment (FibroScan) thyroid-related hormones tests was conducted from 2018 2020 in Xiamen, China. Results: Subjects increasing...