A5040540081- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Vitamin D Research Studies
- Dietary Effects on Health
- Hormonal and reproductive studies
- Molecular Junctions and Nanostructures
- Adipose Tissue and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Thyroid Disorders and Treatments
- Fatty Acid Research and Health
- Circadian rhythm and melatonin
- Diet, Metabolism, and Disease
- Diabetes Treatment and Management
- Menopause: Health Impacts and Treatments
- Advanced biosensing and bioanalysis techniques
- Sodium Intake and Health
- Pathogenesis and Treatment of Hiccups
- Exercise and Physiological Responses
- Facial Trauma and Fracture Management
- Pharmacological Effects and Assays
- High Altitude and Hypoxia
- Nanocluster Synthesis and Applications
- Reproductive Health and Contraception
Southern Medical University
2020-2025
Nanfang Hospital
2020-2025
Institute of High Energy Physics
2024
Key Laboratory of Guangdong Province
2022-2024
University of Chinese Academy of Sciences
2024
Xiamen University
2023
Jiangsu University of Science and Technology
2022
Nanjing University of Science and Technology
2021
We randomly assigned 139 patients with obesity to time-restricted eating (eating only between 8:00 a.m. and 4:00 p.m.) calorie restriction or daily alone. For 12 months, all the participants were instructed follow a calorie-restricted diet that consisted of 1500 1800 kcal per day for men 1200 women. The primary outcome was difference two groups in change from baseline body weight; secondary outcomes included changes waist circumference, body-mass index (BMI), amount fat, measures metabolic...
Importance The efficacy and safety of time-restricted eating (TRE) on nonalcoholic fatty liver disease (NAFLD) remain uncertain. Objective To compare the effects TRE vs daily calorie restriction (DCR) intrahepatic triglyceride (IHTG) content metabolic risk factors among patients with obesity NAFLD. Design, Setting, Participants This 12-month randomized clinical trial including participants NAFLD was conducted at Nanfang Hospital in Guangzhou, China, between April 9, 2019, August 28, 2021....
Abstract Objective To assess the effect of dapagliflozin plus calorie restriction on remission type 2 diabetes. Design Multicentre, double blind, randomised, placebo controlled trial. Setting 16 centres in mainland China from 12 June 2020 to 31 January 2023. Participants 328 patients with diabetes aged 20-70 years, body mass index >25 and duration <6 years. Interventions Calorie 10 mg/day or placebo. Main outcome measures Primary outcome: incidence (defined as glycated haemoglobin...
OBJECTIVE To examine the associations of circulating 25-hydroxyvitamin D (25[OH]D) concentrations with cardiovascular disease (CVD) and all-cause mortality in individuals prediabetes diabetes from large population-based UK Biobank cohort study. RESEARCH DESIGN AND METHODS A total 67,789 diagnosed 24,311 who had no CVD or cancer at baseline were included current Serum 25(OH)D measured baseline. Cox proportional hazard models used to calculate ratios (HRs) 95% CIs for outcomes after 10–14...
Background The associations of oral contraceptive (OC) use with cardiovascular disease (CVD) and all-cause death remains unclear. We aimed to determine the OC incident CVD death. Methods Results This cohort study included 161 017 women who had no at baseline reported their use. divided into ever never Cox proportional hazard models were used calculate ratios 95% CIs for outcomes Overall, 131 (81.4%) participants baseline. multivariable-adjusted users versus 0.92 (95% CI, 0.86-0.99) death,...
Background The association between menstrual cycle characteristics and cardiovascular outcomes remains unclear. This study was undertaken to evaluate whether regularity length throughout the life course are associated with outcomes. Methods Results cohort included 58 056 women who had no disease (CVD) at baseline reported their length. Hazard ratios (HRs) 95% CIs for CVD events were estimated using Cox proportional hazards models. During median 11.8 years of follow-up, 1623 incident cases...
Abstract Single‐atom nanozyme materials have demonstrated exceptional specific catalytic activity due to the atomic‐level dispersion of their active centers. However, exploration mechanisms for single‐atom catalysts is so far limited 2D surfaces nanozymes. In this study, porous Fe (psaFeN) successfully prepared through a straightforward coordination‐assisted polymerization‐assembly strategy. The psaFeN composite nanospheres are uniformly sized, exhibiting excellent dispersibility with...
Adiposity and adipokines are associated with metabolic disorders, but little is known regarding that whether adiposity measurements link syndrome (MetS) through circulating neuregulin 4 (Nrg4) adipsin levels.A total of 1212 subjects a waist circumference greater than 90 cm for men or 80 women were enrolled from Chinese community. Circulating Nrg4 levels measured using commercial kits. Mediation analyses performed in the study linear logistic regression.Subjects MetS had higher circumference,...
Brown adipose tissue (BAT) is the main site of nonshivering thermogenesis which plays an important role in and energy metabolism. However, regulatory factors that inhibit BAT activity remain largely unknown. Here, cardiotrophin-like cytokine factor 1 (CLCF1) identified as a negative regulator BAT. Adenovirus-mediated overexpression CLCF1 greatly impairs thermogenic capacity reduces metabolic rate. Consistently, BAT-specific ablation enhances function expenditure under both thermoneutral cold...
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic diseases worldwide. However, molecular mechanisms that promote dysregulation hepatic triglyceride metabolism and lead to NAFLD are poorly understood, effective treatments limited. Leukemia inhibitory factor (LIF) a member interleukin-6 cytokine family has been shown regulate variety physiological processes, although its role in remains unknown. In present study, we measured circulating LIF levels by ELISA 214 patients...
Relationships between insulin-like growth factor 1 (IGF-1) levels and cardiovascular disease (CVD) in the general population remain unclear.This study aims to investigate association of circulating IGF-1 concentrations with CVD from a population-based cohort study.A total 394 082 participants without cancer at baseline UK Biobank were included measurements serum baseline. Main outcomes incidence CVD, including mortality, coronary heart (CHD), myocardial infarction (MI), failure (HF),...
Background Although numerous studies have investigated the association of dietary intake omega-3 fatty acids with cognitive function and risks dementia, relationship between fish oil supplementation incident dementia in a large population-based cohort study has not yet well studied. Materials methods A total 211,094 community-dwelling older persons over 60 years from UK Biobank cohorts enrolled 2006 2010 that reported regularly taking had no at baseline, was included present study. All...
<b><i>Introduction:</i></b> The association of serum sex hormone-binding globulin (SHBG) concentrations with dementia risk remains uncertain in middle-aged to older women. We examined associations SHBG levels incidence all-cause and its subtypes women from the large population-based UK Biobank cohort study. <b><i>Methods:</i></b> Serum total were measured by immunoassay. was recorded. Cox proportional hazards models used calculate hazard ratios...
Background Diabetic kidney disease (DKD) is the leading cause of end-stage worldwide. Epidemiological evidence association between urinary sodium excretion and presence DKD in patients with type 2 diabetes mellitus (T2DM) has not yet been well established. Methods We performed a cross-sectional study 1545 T2DM over aged 20 years old from January 2018 to December 2020. Urinary was measured by 24-hour urine samples inpatients morning fasting outpatients. The associations risks were examined...
Background: Tsukushi (TSK) is a secreted hepatokine recently identified as playing an important role in modulating glucose and lipid metabolism, systemic energy homeostasis. However, information not available regarding the association between circulating TSK hyperthyroidism humans. Methods: We measured serum levels 180 patients with 82 healthy controls recruited from clinic. Of them, 46 hyperthyroid received thionamide treatment for 3 months. Results: Hyperthyroid had higher of than [186.67...
Glycoprotein non-metastatic protein B (Gpnmb) has been identified as a new cytokine secreted by hepatocyte that plays an important role in balancing lipid homeostasis and development of obesity metabolic disorders. However, information is not available regarding the association between circulating Gpnmb hyperthyroid humans.We measured serum 180 patients 82 healthy subjects were recruited from clinic. Of them, 46 received thionamide treatment for 3 months.Hyperthyroid had higher levels than...
<b>OBJECTIVES</b> <p><a>To examine </a><a>the associations of </a><a></a><a>circulating 25-hydroxyvitamin D (25(OH)D) concentrations </a>with CVD and all-cause mortality in individuals with prediabetes diabetes from the large population-based UK Biobank cohort study.</p> <p><b>RESEARCH DESIGN AND METHODS</b></p> <p>A total 67 789 diagnosed 24 311 who had no or cancer at baseline were...
Abstract Context Sex hormones have been identified as cardiovascular risk factors, whereas the relationship between sex and of arrhythmias in men has not yet well studied prospective cohort study. Objective To analyze associations serum testosterone SHBG concentrations calculate free (cFT) with men. Methods were measured at baseline from UK Biobank. Main outcomes incidence atrial fibrillation/flutter (AF), ventricular arrhythmia (VA), bradyarrhythmia (BA). Results Of 173 498 (aged 37-73...
Characteristic symptoms of hyperthyroidism include weight loss, heart palpitation, and sweating. Thyroid hormones (TH) can stimulate thermogenesis through central peripheral mechanisms. Previous studies have shown an association between dysfunction cardiotrophin-like cytokine factor 1 (CLCF1) cold-induced sweating syndrome, with recent research also indicating a link CLCF1 brown adipose tissue thermogenesis. However, it remains unclear whether TH synergistic or antagonistic effects on This...