A5076117969- Colorectal Cancer Screening and Detection
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Valve Diseases and Treatments
- Epigenetics and DNA Methylation
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Aortic Disease and Treatment Approaches
- RNA modifications and cancer
- Advanced Breast Cancer Therapies
- Infective Endocarditis Diagnosis and Management
- Genetic Associations and Epidemiology
- Inflammatory Bowel Disease
- Cancer-related gene regulation
- Cardiovascular Function and Risk Factors
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Colorectal and Anal Carcinomas
- Ophthalmology and Visual Impairment Studies
Nanjing Drum Tower Hospital
2024-2025
University of Edinburgh
2023-2025
Sichuan University
2008-2025
Chengdu University
2025
Southwest Petroleum University
2025
University of Alabama at Birmingham
2025
Central South University
2022-2024
Second Affiliated Hospital of Zhejiang University
2007-2024
Leibniz Institute of Virology (LIV)
2021-2024
Second Xiangya Hospital of Central South University
2024
In an interim analysis of this phase 3 trial, the addition pembrolizumab to chemotherapy resulted in longer progression-free survival than alone among patients with advanced triple-negative breast cancer whose tumors expressed programmed death ligand 1 (PD-L1) a combined positive score (CPS; number PD-L1–staining tumor cells, lymphocytes, and macrophages, divided by total viable multiplied 100) 10 or more. The results final overall have not been reported.
Purpose: The purpose of this study was to changes in choroidal thickness (ChT) and blood perfusion (ChBP), the correlation between them, guinea pig myopia. Methods: reliability optical coherence tomography angiography (OCTA) for measuring ChT ChBP verified pigs, after cervical dislocation (n = 7) or temporal ciliary artery transection 6). Changes refraction, axial length, ChT, were measured during spontaneous myopia 9), monocular form-deprivation (FDM, n 13), lens-induced (LIM, 14), 4 days...
In patients with early-stage triple-negative breast cancer, the phase 3 KEYNOTE-522 trial showed significant improvements in pathological complete response and event-free survival addition of pembrolizumab to platinum-containing chemotherapy. Here we report final results for overall survival.
INTRODUCTION: The joint associations across genetic risk, modifiable lifestyle factors, and inflammatory bowel disease (IBD) remains unclear. METHODS: Genetic susceptibility to Crohn's (CD) ulcerative colitis (UC) was estimated by polygenic risk scores further categorized into high, intermediate, low categories. Weighted healthy were constructed based on 5 common factors favorable (4 or factors), intermediate (3 unfavorable (0–2 factors) groups. Cox proportional hazards regression model used...
Abstract The resistance of adhesives to organic solvents is paramount importance in diverse industries. Unfortunately, many currently available exhibit either weak intermolecular chain interactions, resulting insufficient solvents, or possess a permanent covalent crosslinked network, impeding recyclability. This study introduces an innovative approach address this challenge by formulating zwitterionic poly(ionic liquid) (ZPIL) derivatives with robust dipole–dipole incorporating sulfonic...
Purpose: In guinea pigs, choroidal thickness (ChT) and blood perfusion (ChBP) simultaneously decrease in experimental myopia, both increase during recovery. However, the causal relationship between ChBP myopia requires further investigation. this study, we examined changes of with three different antimyopia treatments. We also actively increased to examine direct effect on development pigs. Methods: Experiment 1: Guinea pigs wore occluders right eye for two weeks induce form-deprivation...
Myopia is a leading cause of visual impairment and blindness worldwide. However, safe accessible approach for myopia control prevention currently unavailable. Here, we investigated the therapeutic effect dietary supplements omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on progression in animal models decreases choroidal blood perfusion (ChBP) caused by near work, risk factor young adults. We demonstrated that daily gavage ω-3 PUFAs (300 mg docosahexaenoic acid [DHA] plus 60...
Purpose: The development of myopia in guinea pigs can be inhibited by attenuating scleral hypoxia increasing choroidal blood perfusion (ChBP). In this study, we reduced ChBP through surgical and pharmacological methods to determine the effect on development. We also determined whether was quinpirole, a drug that enhances form-deprivation (FDM). Methods: right eyes via transection temporal ciliary arteries or daily injections phenylephrine into inferior peribulbar space for one week during...
Abstract Background Sex hormone-binding globulin (SHBG), testosterone and oestradiol have been associated with many diseases in observational studies; however, the causality of associations remains unestablished. Methods A phenome-wide Mendelian randomization (MR) association study was performed to explore disease outcomes genetically proxied circulating SHBG, levels by using updated genetic instruments 339 197 unrelated White British individuals (54% female) UK Biobank. Two-sample MR...
Abstract This work aims to investigate how smoking exerts effect on the development of inflammatory bowel disease (IBD). A prospective cohort study and a Mendelian randomization are first conducted evaluate association between behaviors, smoking-related DNA methylation risks Crohn’s (CD) ulcerative colitis (UC). We then perform both genome-wide analysis co-localization validate observed associations. Compared never smoking, current previous habits associated with increased CD ( P = 7.09 × 10...
As immune-checkpoint inhibitors (ICIs) therapy has made great strides in hepatocellular carcinoma (HCC) treatment, improving patient response to this strategy become the main focus of research. Accumulating evidence shown that m6A methylation plays a crucial role tumorigenesis and progression HCC, while precise impact demethylase ALKBH5 on tumor immune microenvironment (TIME) HCC remains poorly defined. The clinical significance TIM3 were evaluated human tissues. biological function was...
Lactylation, a post-translational modification, is increasingly recognized for its role in cancer progression. This study investigates prevalence and impact oral squamous cell carcinoma (OSCC).
Abstract Early‐onset colorectal cancer (EOCRC) has been increasing worldwide. Potential risk factors may have occurred in childhood or adolescence. We investigated the associations between early‐life and EOCRC risk, with a particular focus on long‐term recurrent antibiotic use (LRAU) its interaction genetic factors. Data UK Biobank participants recruited 2006 2010 followed up to February 2022 were used. used logistic regression estimate adjusted odds ratios (ORs) 95% confidence intervals...
Patent foramen ovale (PFO) closure is a widely used procedure to manage recurrent cryptogenic stroke, with most complications occurring in the early postimplantation period. Very late device-related thrombosis, especially more than decade after placement, rare presentation unique diagnostic and management challenges. We present case of thromboembolic stroke caused by left atrial mass unknown origin attached PFO occlusion device placed 15 years prior. Pathology suggested an infectious origin,...