A5013573511- Inflammatory Bowel Disease
- Cystic Fibrosis Research Advances
- Shoulder and Clavicle Injuries
- Shoulder Injury and Treatment
- IL-33, ST2, and ILC Pathways
- Vitamin K Research Studies
- Immunodeficiency and Autoimmune Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Diet and metabolism studies
- Immune Cell Function and Interaction
- Pancreatitis Pathology and Treatment
- Epigenetics and DNA Methylation
- Helicobacter pylori-related gastroenterology studies
- Trauma Management and Diagnosis
- Orthopedic Surgery and Rehabilitation
- Digestive system and related health
- Vitamin C and Antioxidants Research
- Neonatal Respiratory Health Research
- Optical Coherence Tomography Applications
- Eosinophilic Esophagitis
- Systemic Sclerosis and Related Diseases
- Tuberculosis Research and Epidemiology
- Microscopic Colitis
- SARS-CoV-2 and COVID-19 Research
- Nutritional Studies and Diet
Poznan University of Medical Sciences
2016-2025
Inserm
2018-2024
Université Paris Cité
2018-2024
John Radcliffe Hospital
2020-2022
University of Oxford
2020-2022
University of Opole
2021
Grochowski Hospital
2021
Institut des Maladies Génétiques Imagine
2018-2020
Roche (Switzerland)
2020
Sequoia (United States)
2020
During 1978 and 1979, we initiated a prospective multicenter study to evaluate the results of nonoperative treatment primary anterior shoulder dislocation. In current report, present outcome after twenty-five years.Two hundred fifty-five patients (257 shoulders) with an age twelve forty years who had dislocation were managed immobilization (achieved by tying arm torso use bandage) or without immobilization. All 227 living (229 completed follow-up questionnaire, 214 Disabilities Arm, Shoulder...
Nonoperative treatment is preferred for clavicular fractures irrespective of fracture and patient characteristics. However, recent studies indicate that long term results are not as favourable previously considered.We have identified predictive risk factors associated with demographic baseline data on fractures. In particular, the following symptoms were investigated: pain at rest, during activity, cosmetic defects, reduction in strength, paresthesia nonunion until 6 months after injury. We...
Although the respiratory tract is implicated as primary portal of entry severe acute syndrome coronavirus-2 (SARS-CoV-2), gastrointestinal involvement well-reported, associated with nausea, vomiting, diarrhea, and highly persistent viral particle shedding in feces.1Xiao F. et al.Gastroenterology. 2020; 158: 1831-1833.e3Abstract Full Text PDF PubMed Scopus (2037) Google Scholar,2Jin X. al.Gut. 69: 1002-1009Crossref (942) Scholar There critical need to establish factors determining...
Abstract This work aims to investigate how smoking exerts effect on the development of inflammatory bowel disease (IBD). A prospective cohort study and a Mendelian randomization are first conducted evaluate association between behaviors, smoking-related DNA methylation risks Crohn’s (CD) ulcerative colitis (UC). We then perform both genome-wide analysis co-localization validate observed associations. Compared never smoking, current previous habits associated with increased CD ( P = 7.09 × 10...
An expanding number of monogenic defects have been identified as causative severe forms very early-onset inflammatory bowel diseases [VEO-IBD]. The present study aimed at defining how next-generation sequencing [NGS] methods can be used to improve identification known molecular diagnosis and adapt treatment.A total 207 children were recruited in 45 paediatric centres through an international collaborative network [ESPGHAN GENIUS working group] with a clinical presentation VEO-IBD [n = 185]...
Twitter has considerable capacity for health education and proves to be an efficient accessible communication tool in the coronavirus disease-19 (COVID-19) pandemic. Although many stakeholders saturate with COVID-19–related information, it remains unknown who disseminates information most efficaciously. tweets were obtained from accounts of agencies, governmental authorities, universities, scientific journals, medical associations, celebrities. Posts' impact was measured nominal relative...
Abstract Aim To assess the pathobiological and translational importance of whole-blood transcriptomic analysis in inflammatory bowel disease [IBD]. Methods We analysed expression profiles from paired-end sequencing a discovery cohort 590 Europeans recruited across six countries IBD Character initiative (newly diagnosed patients with Crohn’s [CD; n = 156], ulcerative colitis [UC; 167], controls [n 267]), exploring differential [DESeq2], co-expression networks [WGCNA], transcription factor...
Abstract Background Epigenetic alterations may provide valuable insights into gene–environment interactions in the pathogenesis of inflammatory bowel disease [IBD]. Methods Genome-wide methylation was measured from peripheral blood using Illumina 450k platform a case-control study an inception cohort (295 controls, 154 Crohn’s [CD], 161 ulcerative colitis [UC], 28 IBD unclassified [IBD-U)] with covariates age, sex and cell counts, deconvoluted by Houseman method. Genotyping performed...
Objective: Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is an autoimmune disease caused by mutations in the forkhead box protein 3 gene (FOXP3), which encodes a key regulator of immune tolerance. The aim this study was to describe clinical heterogeneity national French cohort. Methods: Multicenter retrospective patients diagnosed with IPEX FOXP3. Results: Thirty children from 26 families were included. Age at onset (median [first third quartile]) 1.5 mo...
<ns4:p>The current rapid spread of the novel coronavirus (SARS-CoV-2) causing disease 2019 (COVID-19) calls for a response from research community. Lithium is widely used to treat bipolar disorder, but has been shown exhibit antiviral activity. This brief review took systematic approach identify six<ns4:italic>in vitro</ns4:italic>studies reporting on influence lithium coronaviral infections. We propose mechanistic investigation – alone and with chloroquine SARS-CoV-2 infection.</ns4:p>
Considerable interest has been focused on the design of glenoid component used in total shoulder arthroplasty order to reduce risk loosening. One design-related feature that attracted attention is whether use pegged or keeled cemented components. The main purpose this study was compare fixation components with in-line components.In a prospective randomized study, we compared stability cemented, all-polyethylene, and three-pegged by radiostereometric analysis. Twenty-seven shoulders...
Although vitamin K deficiency has been implicated in adult inflammatory bowel disease (IBD), its prevalence pediatric IBD remains unknown. We carried out a cross-sectional study 63 children with Crohn's (CD) and 48 ulcerative colitis (UC) to assess the of search for potential correlation between status activity. Vitamin was assessed using protein induced by absence-II (PIVKA-II; ELISA). Prevalence 54.0% CD 43.7% UC. more common patients higher activity, mass Z-scores less among treated...
Green tea is known worldwide for its beneficial effects on human health. However, objective data evaluating this influence in humans scarce. The aim of the study was to assess impact green extract (GTE) starch digestion and absorption. comprised 28 healthy volunteers, aged 19 years. In all subjects, a (13)C breath test performed twice. Subjects randomly ingested naturally (13)C-abundant cornflakes during GTE (GTE 4 g) or placebo test. cumulative percentage dose recovery (CPDR) significantly...
AimTo investigate the contribution of selected types articles to h-indices medical researchers.MethodsWe used Web Science export publication records various members from 26 scientific societies (13 European, 13 North American) associated with specialties. Those included were presidents (n = 26), heads randomly chosen committees 52), and those 52). Publications contributing h-index categorized as research articles, reviews, guidelines, meta-analyses, or other published work.ResultsOverall,...
Single genetic mutations predispose to very early onset inflammatory bowel disease (VEO-IBD). Here, we identify a de novo duplication of the 10p15.1 chromosomal region, including IL2RA locus, in 2-year-old girl with treatment-resistant pancolitis that was brought into remission by colectomy. Strikingly, after colectomy while patient clinical and without medication, peripheral blood CD4:CD8 ratio constitutively high CD25 expression increased on circulating effector memory, Foxp3+, Foxp3neg...