Petr Ricanek
A5031872804- Inflammatory Bowel Disease
- Microscopic Colitis
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Immunodeficiency and Autoimmune Disorders
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Epigenetics and DNA Methylation
- Mycobacterium research and diagnosis
- Biosimilars and Bioanalytical Methods
- SARS-CoV-2 and COVID-19 Research
- Pregnancy and Medication Impact
- Gastrointestinal motility and disorders
- Celiac Disease Research and Management
- Diagnosis and treatment of tuberculosis
- Digestive system and related health
- Lymphoma Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Diverticular Disease and Complications
- Autoimmune and Inflammatory Disorders
- Inflammasome and immune disorders
- Adolescent and Pediatric Healthcare
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Pharmaceutical studies and practices
Lovisenberg Diakonale Høgskole
2023-2025
Akershus University Hospital
2016-2025
University of Bristol
2022
University of Oslo
2011-2022
Medical Research Council
2022
Oslo University Hospital
2010-2015
Chungnam National University Hospital
2015
Daejeon University
2015
Abstract Epigenetic alterations may provide important insights into gene-environment interaction in inflammatory bowel disease (IBD). Here we observe epigenome-wide DNA methylation differences 240 newly-diagnosed IBD cases and 190 controls. These include 439 differentially methylated positions (DMPs) 5 regions (DMRs), which study detail using whole genome bisulphite sequencing. We replicate the top DMP ( RPS6KA2 ) DMRs VMP1, ITGB2 TXK an independent cohort. Using paired genetic epigenetic...
Objective: To assess the efficacy, tolerability, and safety of CT-P13 (Remsima®) in patients with Crohn's disease (CD) or ulcerative colitis (UC). Methods: This was a prospective observational study performed single center Norway. Patients CD (n = 46) UC 32) received (5 mg/kg) by intravenous infusion at weeks 0, 2, 6. Efficacy end points included remission week 14, measured Harvey-Bradshaw Index score ≤4 partial Mayo ≤2. Levels inflammatory markers C-reactive protein calprotectin were...
Preclinical ulcerative colitis is poorly defined. We aimed to characterize the preclinical systemic inflammation in colitis, using a comprehensive set of proteins.We obtained plasma samples biobanked from individuals who developed later life (n = 72) and matched healthy controls 140) within population-based screening cohort. measured 92 proteins related proximity extension assay. The biologic relevance these findings was validated an inception cohort patients with 101) 50). To examine...
Although the respiratory tract is implicated as primary portal of entry severe acute syndrome coronavirus-2 (SARS-CoV-2), gastrointestinal involvement well-reported, associated with nausea, vomiting, diarrhea, and highly persistent viral particle shedding in feces.1Xiao F. et al.Gastroenterology. 2020; 158: 1831-1833.e3Abstract Full Text PDF PubMed Scopus (2037) Google Scholar,2Jin X. al.Gut. 69: 1002-1009Crossref (942) Scholar There critical need to establish factors determining...
Objective Immunogenicity and safety following receipt of the standard SARS–CoV‐2 vaccination regimen in patients with immune‐mediated inflammatory diseases (IMIDs) are poorly characterized, data after third vaccine dose lacking. The aim study was to evaluate serologic responses adverse events 2‐dose a IMID receiving immunosuppressive therapy. Methods Adult therapy for rheumatoid arthritis, spondyloarthritis, psoriatic Crohn's disease, or ulcerative colitis, as well healthy adult controls,...
Abstract Background Distinguishing irritable bowel syndrome (IBS) from inflammatory disease (IBD) flare-ups is challenging. This study used objective remission markers to accurately determine IBS prevalence in a population-based cohort of patients with IBD. Methods Adults ulcerative colitis and Crohn’s were recruited the IBD South-Eastern Norway III study. Irritable bowel-like symptoms assessed using Rome IV criteria for at 1- 3-year follow-ups. Remission was defined objectively biochemical...
Abstract Background and Aims The diagnostic prognostic properties of anti-integrin αvβ6 IgG autoantibodies in ulcerative colitis (UC) are poorly understood. We aimed to assess the performance examine their association with disease outcomes. Methods Serum samples from a Swedish inception cohort patients suspected inflammatory bowel (IBD, n=473) were analysed using an in-house fluorescence enzyme immunoassay based on EliA™technology. Findings validated Norwegian population-based (n=570)....
Objective. The present population based adult cohort was part of a new prospective study patients with inflammatory bowel disease (IBD) in South-Eastern Norway, the Inflammatory Bowel Norway II study, investigating characteristics an attempt to improve our knowledge regarding factors related early clinical phenotype and activity. Material methods. Patients suspected have IBD on basis predefined symptoms, including abdominal pain, diarrhea, and/or blood stool for more than 10 days were...
The aim of this study was to investigate the relationship between aquaporin (AQP) water channel expression and pathological features early untreated inflammatory bowel disease (IBD) in humans.Patients suspected have IBD on basis predefined symptoms, including abdominal pain, diarrhea, and/or blood stool for more than 10 days, were examined at local hospital. Colonoscopy with biopsies performed samples taken. Patients who did not meet diagnostic criteria displayed no evidence infection or...
Imbalance in the microbiota, dysbiosis, has been identified inflammatory bowel disease (IBD). We explored fecal microbiota pediatric patients with treatment-naïve IBD, non-IBD gastrointestinal symptoms and healthy children, its relation to IBD subgroups, treatment outcomes.Fecal samples were collected from 235 children below 18 years of age. Eighty had Crohn's (CD), 27 ulcerative colitis (UC), 3 unclassified, 50 symptomatic patients, 75 healthy. The bacterial abundance 54 predefined DNA...
Abstract Background Success in personalized medicine complex disease is critically dependent on biomarker discovery. We profiled serum proteins using a novel proximity extension assay [PEA] to identify diagnostic and prognostic biomarkers inflammatory bowel [IBD]. Methods conducted prospective case-control study an inception cohort of 552 patients [328 IBD, 224 non-IBD], profiling recruited across six centres. Treatment escalation was characterized by the need for biological agents or...
Abstract Aim To assess the pathobiological and translational importance of whole-blood transcriptomic analysis in inflammatory bowel disease [IBD]. Methods We analysed expression profiles from paired-end sequencing a discovery cohort 590 Europeans recruited across six countries IBD Character initiative (newly diagnosed patients with Crohn’s [CD; n = 156], ulcerative colitis [UC; 167], controls [n 267]), exploring differential [DESeq2], co-expression networks [WGCNA], transcription factor...
Abstract Background Epigenetic alterations may provide valuable insights into gene–environment interactions in the pathogenesis of inflammatory bowel disease [IBD]. Methods Genome-wide methylation was measured from peripheral blood using Illumina 450k platform a case-control study an inception cohort (295 controls, 154 Crohn’s [CD], 161 ulcerative colitis [UC], 28 IBD unclassified [IBD-U)] with covariates age, sex and cell counts, deconvoluted by Houseman method. Genotyping performed...
Our knowledge about the microbiota associated with onset of IBD is limited. The aim our study was to investigate correlation between and fecal for early diagnosed untreated patients. samples used were a part Inflammatory Bowel South-Eastern Norway II (IBSEN II) collected from CD patients (n = 30), UC 33), unclassified (IBDU) 3), control group 34). bacteria analyzed using direct 16S rRNA gene-sequencing approach combined multivariate curve resolution (MCR) analysis. In addition, gene clone...
Method We examined faecal samples, using the GA-map™ Dysbiosis Test, to associate gut microbiota composition with Crohn’s disease (CD) and ulcerative colitis (UC) identify markers for future biomarker identification. conducted a prospective case-control study (EU-ref. no. 305676) in an inception cohort of 324 individuals (64 CD, 84 UC, 116 symptomatic non-IBD controls 44 healthy controls) across five European centres 54 predetermined bacterial markers. categorized patients according Montreal...
Abstract Background Patients with inflammatory bowel disease report multiple symptoms, but the relationships among co-occurring symptoms are poorly understood. This study aimed to examine prevalence of and explore symptom clusters possible associations between socio-demographic clinical variables in patients newly diagnosed disease. Methods The IBSEN III is a prospective population-based inception cohort used patient data from three largest hospitals catchment area. Memorial Symptom...
Background: Dietary recommendations in inflammatory bowel disease (IBD) are inconclusive, and patients may follow restrictive diets with increased risk of malnutrition. The aim this study was to compare dietary intakes nutritional status men women newly diagnosed IBD a general population sample, investigate whether were line the Nordic Nutrition Recommendations. Methods: This cross-sectional including adults≥ 40 years from Inflammatory Bowel Disease South-Eastern Norway (IBSEN) III cohort...
MicroRNAs [miRNAs] are cell-specific small non-coding RNAs that can regulate gene expression and have been implicated in inflammatory bowel disease [IBD] pathogenesis. Here we define the miRNA profiles investigate its biomarker potential IBD.In a two-stage prospective multi-centre case control study, next generation sequencing was performed on discovery cohort of immunomagnetically separated leukocytes from 32 patients (nine Crohn's [CD], 14 ulcerative colitis [UC], eight healthy controls)...
Summary Background The introduction of biologic therapies and the ‘treat‐to‐target’ treatment strategy may have changed disease course ulcerative colitis (UC). Aims To describe early outcome at 1‐year follow‐up in a population‐based inception cohort adult patients with newly diagnosed UC. Methods Inflammatory Bowel Disease South‐Eastern Norway (IBSEN) III study is prospective follow‐up. Patients inflammatory bowel during 2017–2019 were included. ≥18 years diagnosis UC who attended...
Abstract Background Multiple alterations in the immune repertoire of IBD patients have been identified including, an expansion a subset type II natural killer T cells CD patients, termed Crohn’s-associated invariant (CAIT)1. Previously, we showed that CAIT respond to small molecules resemble multiple microbial and drug metabolites2. This begs question whether are expanded due ongoing disease or medications administrated control disease. Methods We profiled cell receptor alpha chain 246...
Abstract Background Fatigue is common in both Crohn's disease (CD) and ulcerative colitis (UC), but the pathogenesis still unclear. The primary aim of this study was to assess odds for substantial fatigue (SF) chronic (CF) one year after diagnosis based on presence SF at baseline. secondary identify clinical factors that may be associated with diagnosis. Methods Patients ≥18 years a definite CD or UC 1-year follow-up were recruited from Inflammatory Bowel Disease South-Eastern Norway (IBSEN...
Abstract Introduction We aimed to determine the diagnostic and prognostic potential of baseline microbiome profiling in inflammatory bowel disease (IBD). Methods Participants with ulcerative colitis (UC), Crohn’s (CD), suspected IBD, non-IBD symptomatic controls were included prospective population-based cohort Inflammatory Bowel Disease South-Eastern Norway III (third iteration) based on suspicion IBD. The participants donated fecal samples that analyzed 16S rRNA sequencing. course severity...