A5066934211- Microscopic Colitis
- Inflammatory Bowel Disease
- Gastrointestinal Bleeding Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Advanced Data Compression Techniques
- Esophageal and GI Pathology
- Gastrointestinal motility and disorders
- Eosinophilic Esophagitis
- Vitamin D Research Studies
- Helicobacter pylori-related gastroenterology studies
- Image Retrieval and Classification Techniques
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Speech and Audio Processing
- Esophageal Cancer Research and Treatment
- Celiac Disease Research and Management
- Gastroesophageal reflux and treatments
- Liver Diseases and Immunity
- Diagnosis and treatment of tuberculosis
- Autoimmune and Inflammatory Disorders
- Gastric Cancer Management and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Digestive system and related health
- Health Systems, Economic Evaluations, Quality of Life
- Gut microbiota and health
- Healthcare Systems and Technology
University of Oslo
2016-2025
Innlandet Hospital Trust
2016-2025
Norwegian University of Science and Technology
2023
Oslo University Hospital
2016
Creative Research Enterprises (United States)
2016
Azienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele
2013
Inland Hospital
2007
Virginia Mason Medical Center
2003
Sørlandet Sykehus
2001
Drammen Hospital
1995
In celiac disease, small intestinal transglutaminase 2 causes deamidation of glutamine residues in gluten peptides, which enhances stimulation T cells and leads to mucosal injury. Inhibition is a potential treatment for disease.In proof-of-concept trial, we assessed the efficacy safety 6-week with ZED1227, selective oral inhibitor, at three dose levels as compared placebo, adults well-controlled disease who underwent daily challenge. The primary end point was attenuation gluten-induced...
Vitamin D deficiency is common in inflammatory bowel disease (IBD). The aims of the present study were to determine prevalence vitamin and identify clinical epidemiological variables associated with an outpatient population IBD.Participants recruited from nine hospitals southeastern western regions Norway as part observational, multicentre March 2013 April 2014. Clinical data collected by interview medical records. All analyses serum 25-hydroxyvitamin (25-OH-D) performed same laboratory.In...
Abstract Transglutaminase 2 (TG2) plays a pivotal role in the pathogenesis of celiac disease (CeD) by deamidating dietary gluten peptides, which facilitates antigenic presentation and strong anti-gluten T cell response. Here, we elucidate molecular mechanisms underlying efficacy TG2 inhibitor ZED1227 performing transcriptional analysis duodenal biopsies from individuals with CeD on long-term gluten-free diet before after 6-week challenge combined 100 mg per day or placebo. At transcriptome...
Patients with inflammatory bowel disease [IBD] often suffer from rheumatic manifestations, including back disorders. The prevalence of these disorders late in the course IBD is poorly investigated. aim this study was to estimate patients 20 years after diagnosis, and investigate possible associations severity, HLA-B27, NOD2 genotype.A population-based cohort [the IBSEN study] followed prospectively for years. Information covering activity diseases collected at regular follow-ups. HLA-B27...
Objective: Fatigue is a major concern for patients with ulcerative colitis (UC) and Crohn's disease (CD), but evidence from population-based studies regarding fatigue in long-standing inflammatory bowel (IBD) scarce. Our aims were to assess scores the prevalence of chronic IBD 20 years after diagnosis identify variables associated this cohort.Methods: Twenty diagnosis, cohort incident invited follow-up visit that included structured interview, clinical examination, laboratory tests...
Whether patients with inflammatory bowel diseases [IBDs] have increased risk of developing cancer has been debated. The aims the study were to determine prevalence intestinal/extraintestinal cancers in an IBD cohort 20 years after diagnosis and assess whether these had cancer-specific compared a matched control population. Patients ulcerative colitis [UC] Crohn′s disease [CD] diagnosed 1990–1993 prospectively followed up for years. Follow-up visits carried out 1, 5, 10, inclusion. Data on...
The long-term course of ulcerative colitis [UC] is difficult to predict. Mortality, colectomy, cancer, and hospitalisation represent hard outcomes disease. Moreover, knowledge on the risk relapses need for potent medication add important information about living with UC. We aimed evaluate prognosis UC during first 20 years after diagnosis, identify early prognostic factors.From 1990 1994, a population-based inception cohort patients inflammatory bowel disease was enrolled in South-Eastern...
Background: Topical treatment is effective in patients with distal ulcerative colitis. This trial compares the efficacy, safety, and practicality of 4 weeks' 500 mg mesalazine suppositories those 178 hydrocortisone foam, both given twice daily. Methods: Seventy-nine colitis were stratified on basis extent disease (proctitis proctosigmoiditis) randomized to one groups. A activity index (DAI) based symptoms endoscopic findings was calculated. The evaluated regimens, patient compliance...
Perceived milk intolerance is a common complaint, and tests for lactose malabsorption (LM) are unreliable. This study assesses the agreement between diagnostic LM describes properties of tests.Patients above 18 years age with suspected were included. After oral intake 25 g lactose, combined test measurement serum glucose (s-glucose) hydrogen (H2) methane (CH4) in expired air was performed symptoms recorded. In patients discrepancies results, repeated gene non-persistence added. The diagnosis...
Population-based studies have shown a slightly decreased life expectancy in patients with Crohn's disease (CD). The primary aim of the present study was to evaluate mortality and causes death 20 years after diagnosis well defined population-based cohort CD Norway.The Inflammatory Bowel South-Eastern Norway has prospectively followed all diagnosed period between 1 January 1990 31 December 1993 four geographically well-defined areas. All (n=237) were age sex matched 25 persons from same county...
Background and Aims . No patient-reported outcome measures targeting pain have yet been validated for use in IBD patients. Consequently, the aim of this study was to test psychometrical properties brief inventory (BPI) an outpatient population with IBD. Methods Participants were recruited from nine hospitals southeastern western parts Norway. Clinical sociodemographic data collected, participants completed BPI, as well Short-Form 36 (SF-36). Results In total, 410 patients included. The BPI...
Abstract Background and Aims Patients with longstanding inflammatory bowel disease [IBD] may be at an increased risk of death compared to the general population, especially elderly patients. The Inflammatory Bowel South-Eastern Norway [IBSEN] study has previously detected a small but not statistically significant increase in mortality 20 years after diagnosis. aim this was evaluate overall cause-specific 30 follow-up. Methods IBSEN cohort included 519 incident patients ulcerative colitis...
Abstract Background and Aims Although fatigue is common in inflammatory bowel disease [IBD], its pathogenesis remains unclear. This study aimed to determine the prevalence of associated factors a cohort patients newly diagnosed with IBD. Methods Patients ≥18 years old were recruited from Inflammatory Bowel Disease South-Eastern Norway [IBSEN III] study, population-based, observational inception cohort. Fatigue was assessed using Questionnaire compared data Norwegian general population....
Background: Dietary recommendations in inflammatory bowel disease (IBD) are inconclusive, and patients may follow restrictive diets with increased risk of malnutrition. The aim this study was to compare dietary intakes nutritional status men women newly diagnosed IBD a general population sample, investigate whether were line the Nordic Nutrition Recommendations. Methods: This cross-sectional including adults≥ 40 years from Inflammatory Bowel Disease South-Eastern Norway (IBSEN) III cohort...
AIMTo investigate if vitamin D deficiency is associated with fatigue in patients inflammatory bowel disease (IBD).
Colorectal polyps are important precursors to colon cancer, the third most common cause of cancer mortality for both men and women. It is a disease where early detection crucial importance. Colonoscopy commonly used precancerous pathology. demanding procedure requiring significant amount time from specialized physicians nurses, in addition miss-rates by specialists. Automated polyp colonoscopy videos has been demonstrated be promising way handle this problem. {However, challenging problem...
Background: The effect of acid secretion inhibitors in patients with functional dyspepsia (FD) is equivocal. One previous trial showed an a characteristic gastro-oesophageal reflux pattern. This double-blind compares the number episodes responders and non-responders to omeprazole. Methods: Twenty-four (men/women, 11:13; mean age, 49 years) FD were included; those as main symptom excluded. An upper endoscopy 24-h oesophageal pH measurement performed before randomization treatment 10-20 mg...
Summary Background The introduction of biologic therapies and the ‘treat‐to‐target’ treatment strategy may have changed disease course ulcerative colitis (UC). Aims To describe early outcome at 1‐year follow‐up in a population‐based inception cohort adult patients with newly diagnosed UC. Methods Inflammatory Bowel Disease South‐Eastern Norway (IBSEN) III study is prospective follow‐up. Patients inflammatory bowel during 2017–2019 were included. ≥18 years diagnosis UC who attended...
Abstract Background Despite the well-established involvement of gut microbiota in inflammatory bowel disease (IBD), little is known about how changes over time or it varies with clinical activity and faecal calprotectin. To address this gap, we utilized population-based inception cohort IBSEN III. Methods Stool samples from IBD patients symptomatic controls (SC) were collected at diagnosis after 3, 6, 12 months. Comprehensive data collection was performed baseline 12-month follow-up, while...
Abstract Background Fatigue is common in both Crohn's disease (CD) and ulcerative colitis (UC), but the pathogenesis still unclear. The primary aim of this study was to assess odds for substantial fatigue (SF) chronic (CF) one year after diagnosis based on presence SF at baseline. secondary identify clinical factors that may be associated with diagnosis. Methods Patients ≥18 years a definite CD or UC 1-year follow-up were recruited from Inflammatory Bowel Disease South-Eastern Norway (IBSEN...