A5078812256- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Synthetic Organic Chemistry Methods
- Sulfur Compounds in Biology
- Advanced Nanomaterials in Catalysis
- Extracellular vesicles in disease
- Catalytic C–H Functionalization Methods
- MicroRNA in disease regulation
- Asymmetric Synthesis and Catalysis
- Glycosylation and Glycoproteins Research
- Ubiquitin and proteasome pathways
- Fibroblast Growth Factor Research
- Nanocluster Synthesis and Applications
- Cyclopropane Reaction Mechanisms
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Protein purification and stability
- Monoclonal and Polyclonal Antibodies Research
- Catalytic Alkyne Reactions
- Photodynamic Therapy Research Studies
- Synthesis and Biological Activity
- Autophagy in Disease and Therapy
- Protein Degradation and Inhibitors
Henan University
2017-2024
First Affiliated Hospital of Henan University
2024
United Imaging Healthcare (China)
2019-2024
University of Kansas
2009-2019
Kaifeng University
2018-2019
State Key Laboratory of Cotton Biology
2019
First Affiliated Hospital of Zhengzhou University
2016-2018
Zhengzhou University
2018
New Mexico State University
2007-2011
Therapeutic strategies based on modulation of microRNAs (miRNAs) activity hold much promise for cancer therapy, but clinical applications, the efficient delivery miRNAs to tumor cells or tissues remains a great challenge. In this work, microRNA‐181b inhibitor (anti‐miR‐181b) is successfully condensed into polyethyleneimine (PEI)‐modified and folate receptor (FR)‐targeted PEGylated gold nanocages (AuNCs). This system designated as anti‐miR‐181b/PTPAuNCs nanocomplexes (PTPAuNC‐NPs), which...
Abstract Chemodynamic therapy (CDT) has great potential in cancer treatment, but its efficacy is limited due to non‐specificity, insufficient hydrogen peroxide (H 2 O ), and excessive glutathione (GSH) within the tumor microenvironment (TME). Here, an intelligent nanoplatform (Fe 3 4 @MnO @NO@Au NPs, abbreviated as CD44 FMNA) reported for treatment of breast cancer, which constructed with Fe nanoparticles (NPs) core coated manganese dioxide (MnO ) nanoshells encapsulating NO donors gold (Au...
Background: Targeted delivery systems have been developed to improve cancer treatment by reducing side effects and enhancing drug efficacy. Geraniol, a natural product, has demonstrated promising anti-cancer in various types, including prostate cancer, which is the most commonly diagnosed men. Hyaluronic acid (HA), carrier targeting CD44-positive cells, can be utilized targeted system. Purpose: This study investigated efficacy of conjugate HA geraniol linked via disulfide bond linker...
Abstract: Breast cancer is the most commonly diagnosed and leading cause of deaths in women globally. In 2018, 2.1 million new cases were reported, with 627,000 deaths. Pakistan has highest incidence rate breast among Asian countries: one every nine a lifetime risk being cancer. By reason many misconceptions about etiology disease socioeconomic factors, Pakistani have very low rates early detection diagnose at advance stages fewer chances survival. The key to cure diagnosis. aim current...
Changes in the cerebral microenvironment caused by acute ischemic stroke-reperfusion are main obstacle to recovery of neurological function and an important cause stroke recurrence after thrombolytic therapy. The intracerebral ischemia-reperfusion reduces neuroplasticity penumbra ultimately leads permanent damage. To overcome this challenge, we developed a triple-targeted self-assembled nanodelivery system, which combines neuroprotective drug rutin with hyaluronic acid through esterification...
The effects of secondary structure on asparagine (N) deamidation in a 22 amino acid sequence (369-GFYPSDIAVEWESNGQPENNYK-390) the crystallizable (Fc) fragment human monoclonal antibody (Fc IgG1) were investigated using high-resolution ultra performance liquid chromatography with tandem mass spectrometry (UPLC/MS). Samples containing either intact Fc IgG (approximately 50 kD) ("intact protein"), or corresponding synthetic peptides ("peptide") stored Tris buffer at 37 degrees C and pH 7.5 for...
Diaphragm dysfunction is an important clinical problem worldwide. Hydrogen sulfide (H2S) involved in many physiological and pathological processes mammals. However, the effect mechanism of H2S diaphragm have not been fully elucidated. In this study, we detected that level was decreased lipopolysaccharide- (LPS-) treated L6 cells. Treatment with increased proliferation viability LPS-treated We found reactive oxygen species- (ROS-) induced apoptosis through mitogen-activated protein kinase...
Postoperative tumor recurrence remains a predominant cause of treatment failure. In this study, we developed an in situ injectable hydrogel, termed MPB-NO@DOX + ATRA gel, which was locally formed within the resection cavity. The gel fabricated by mixing thrombin solution, fibrinogen solution containing all-trans retinoic acid (ATRA), and Mn/NO-based immune nano-activator MPB-NO@DOX. promoted differentiation cancer stem cells, inhibited cell migration, affected polarization tumor-associated...
The synthesis of naphthalene derivatives through three-component coupling 2-alkynylbenzaldehyde hydrazones with carbene complexes and electron-deficient alkynes has been examined. reaction involves formation an isoindole derivative, followed by intramolecular Diels−Alder reaction, nitrene extrusion. was highly regioselective using unsymmetrical alkynes.
TGX-221 is a potent, selective, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit. Recent studies showed that has antiproliferative activity against PTEN-deficient tumor lines including prostate cancers. The objective this study was to develop an encapsulation system for parenterally delivering target tissue through prostate-specific aptamer (PSMAa10) with little or no side effects. In study, PEG-PCL micelles were formulated encapsulate drug, prodrug strategy pursued...
Alternol is a natural compound isolated from fermentation products of mutant fungus. Our previous studies demonstrated that specifically kills cancer cells but spares benign cells.To investigate the mechanism underlying alternol-induced cell-specific killing effect, we took comprehensive strategy to identify Alternol's protein targets in prostate cells, including PC-3, C4-2, and 22RV1, plus BPH1 cell lines. Major experimental techniques included biotin-streptavidin pulldown assay coupled...