Abstract Among all cancer treatment options, chemotherapy continues to play a major role in killing free cells and removing undetectable tumor micro-focuses. Although chemotherapies are successful some cases, systemic toxicity may develop at the same time due lack of selectivity drugs for tissues cells, which often leads failure chemotherapies. Obviously, therapeutic effects will be revolutionarily improved if human can deliver anticancer with high or tissues. This selective delivery has...

Therapeutic strategies based on modulation of microRNAs (miRNAs) activity hold much promise for cancer therapy, but clinical applications, the efficient delivery miRNAs to tumor cells or tissues remains a great challenge. In this work, microRNA‐181b inhibitor (anti‐miR‐181b) is successfully condensed into polyethyleneimine (PEI)‐modified and folate receptor (FR)‐targeted PEGylated gold nanocages (AuNCs). This system designated as anti‐miR‐181b/PTPAuNCs nanocomplexes (PTPAuNC‐NPs), which...

Abstract Currently, cell membrane is always utilized for the construction of biomimetic nanoparticles. By contrast, mimicking intracellular activity seems more meaningful. Inspired by specific killing mechanism deoxy‐hemoglobin (Hb) dependent drug (RRx‐001) in hypoxic red blood cells (RBC), this work aims to develop an inner and outer RBC‐biomimetic antitumor nanoplatform that replicates both surface properties intracellularly certain therapeutic mechanisms RRx‐001 RBC. Herein, Hb are...

Poor tumor accumulation, rapid clearance from blood circulation, and high risk of invasive metastasis are the major barriers that encumber conventional nanodrug-based therapy. In this work, macrophage membrane (M)-camouflaged quercetin (QE)-loaded hollow bismuth selenide nanoparticles (abbreviated as M@BS-QE NPs) fabricated for combination therapy breast cancer. The resulting NPs comprehensively characterized, possessing prolonged circulation life, well accelerated enhanced tumoritropic...

Abstract Tumor fibrotic stroma forms complex barriers for therapeutic nanomedicine. Although nanoparticle vehicles are promising in overcoming biological drug delivery, fibrosis causes hypoxia, immunosuppression and limited immunocytes infiltration, thus reduces antitumor efficacy of nanosystems. Herein, we report the development cancer‐associated fibroblasts (CAFs) responsive honeycomb‐like nanoassemblies carbon dots (CDs) to spatially program delivery multiple therapeutics enhanced...

Either hypoxia in an acute ischemic stroke before thrombolysis or the oxygen-boost after cause a high level of free radicals, resulting successive injuries to neurocytes. To treat stroke, it is needed scavenge combining sequentially regulating and microenvironment. Here, we report engineered nanosponge (Mn3O4@nanoerythrocyte-T7, MNET) that could remodel microenvironment by self-adapted oxygen radical scavenging. With long circulation time blood due stealth effect erythrocyte preferential...

Abstract Spores, the dormant life forms of probiotics, can germinate to metabolically active vegetative cells with disintegration their hydrophobic protein coat in intestinal microenvironment, which provides possibility for formation nanoparticles (NPs) vivo. Inspired by natural physiological process spores, herein, an oral autonomous NPs generator is developed overcome spatially variable gastrointestinal tract environment and multibiological barriers. Spores modified deoxycholic acid (DA)...

Abstract Sonodynamic therapy (SDT) shows tremendous potential to induce immunogenic cell death (ICD) and activate antitumor immunity. However, it can aggravate hypoxia release platelet (PLT)‐associated danger‐associated molecular patterns (DAMPs), which impede therapeutic efficacy promote tumor metastasis. In order solve these problems, a biomimetic decoy (designated as Lipo‐Ce6/TPZ@M H ) is constructed reverse the drawbacks of SDT by loading sonosensitizer chlorin e6 (Ce6) hypoxia‐activated...

Oral drug delivery systems (ODDSs) have attracted considerable attention in relation to orthotopic colon cancer therapy due certain popular advantages. Unfortunately, their clinical applications are generally limited by the side-effects caused systemic exposure and poor real-time monitoring capabilities. Inspired characteristics of pH changes gastrointestinal tract (GIT) specific enzymes secreted colonic microflora, we anchored polyacrylic acid (PAA) chitosan (CS) on Gd3+-doped mesoporous...

Magnetostriction of ferromagnetic materials describes the change their shape or dimension in response to reorientation magnetization under influence external magnetic field. Fe(100-x)Ga(x) binary alloys (Galfenol) have large magnetostriction and excellent ductility; they are very promising rare-earth free for applications sensors, actuators, energy-harvesters spintronic devices. Here we report results large-scale ab initio molecular dynamics (AIMD) simulations Galfenol, especially regarding...

For efficient delivery of small interfering RNA (siRNA) to the target diseased site in vivo, it is important design suitable vehicles control blood circulation siRNA. It has been shown that surface modification cationic liposome/siRNA complexes (lipoplexes) with polyethylene glycol (PEG) could enhance time lipoplexes. However, first injection PEGylated lipoplexes vivo induces accelerated clearance and enhances hepatic accumulation following injected lipoplexes, which known as (ABC)...

SWNTs composite has a great potential as sensitizer for PDT.

Single-walled carbon nanotubes (SWCNTs), an important class of artificial nanomaterials with unique physicochemical properties, were used as novel carriers curcumin.Formulation and evaluation curcumin-loaded SWCNTs systems for utilizing the curcumin's anticancer potential by circumventing conventional limitations extremely low aqueous solubility instability under physiological conditions, combining photothermal therapy enabled strong optical absorbance in 0.8-1.4 μm resulting excessive local...

We report on the magneto-transport properties of chemical vapor deposition grown films interconnected Bi2Te3 nanoplates. Similar to many other topological insulator (TI) materials, these granular exhibit a linear magneto-resistance (LMR) effect which has received much recent attention. Studying samples with different degree granularity, we find universal correlation between magnitude LMR and average mobility (<\mu>) over nearly two orders change <\mu>. The granularity controlled here is...

Abstract Sonodynamic therapy (SDT) always causes tumor hypoxia aggravation which can induce malignant cell proliferation and drug resistance. To overcome these disadvantages, a cascaded delivery system (Lipo/HMME/ACF@MnO 2 ‐AS1411) is constructed for synergistic enhanced sonodynamic therapy. First, hematoporphyrin monomethyl ether (HMME) acriflavine (ACF) are encapsulated in the lipid layers inner aqueous cores of liposomes, respectively. Then ultrathin manganese dioxide (MnO ) nanosheets...

Schematic illustration of design functional liposomes showing radiofrequency-triggered drug release (A) and RF targeted thermo-chemotherapy using the nanocomposite (B).

Abstract Low‐dose photodynamic therapy (PDT) holds great promise for reducing undesired patient photosensitivity in cancer treatment. Yet, its therapeutic effect is significantly affected by intracellular cytoprotective processes, such as autophagy. Here, an efficient autophagy suppressor developed, which a multifunctional DNA nanoflower (DNF) consisted of tumor‐targeting aptamers and DNAzymes silencing autophagy‐related genes, with surface modification low‐dose photosensitizer (Ce6). It...

The compound Ho2In exhibits two successive magnetic phase transitions: a spin-reorientation transition at TSR=32 K and magnetic-ordering TC=85 K. maximum reversible −ΔSM values are 6.3 11.2 J/kg TSR TC, respectively, for field change of 5 T. These peaks with the same sign partly overlapping, which results in wide temperature interval appreciable magnetocaloric effect. on indicate that materials SR transitions may constitute an important new class refrigerants since they work wider range than...