A5018914638- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Catalytic C–H Functionalization Methods
- Advanced Nanomaterials in Catalysis
- Epigenetics and DNA Methylation
- Carbon Nanotubes in Composites
- Diet and metabolism studies
- Catalytic Cross-Coupling Reactions
- X-ray Diffraction in Crystallography
- RNA Interference and Gene Delivery
- Crystallization and Solubility Studies
- Advanced Chemical Physics Studies
- Effects and risks of endocrine disrupting chemicals
- Probiotics and Fermented Foods
- Protein Hydrolysis and Bioactive Peptides
- Fullerene Chemistry and Applications
- RNA and protein synthesis mechanisms
- Molecular spectroscopy and chirality
- Graphene research and applications
- Antifungal resistance and susceptibility
- Cancer-related gene regulation
- Liver Disease Diagnosis and Treatment
Nankai University
2012-2025
Henan University of Technology
2015-2025
Huazhong University of Science and Technology
2020-2025
Shanghai Veterinary Research Institute
2023-2025
Ministry of Ecology and Environment
2021-2025
Zhengzhou University
2004-2025
Advanced Energy Materials (United States)
2025
Henan University of Science and Technology
2012-2024
Wuhan University
2014-2024
Wuhan University of Technology
2015-2024
SOX genes encode a family of high-mobility group transcription factors that play critical roles in organogenesis. The functional specificity different proteins and the tissue particular factor are largely determined by differential partnership with other regulators, many which have not yet been discovered. Virtually all members found to be deregulated wide variety tumors. However, little is known about cellular molecular behaviors involved oncogenic potential proteins. Using cell culture...
Essential for embryonic development, the polycomb group protein enhancer of zeste homolog 2 (EZH2) is overexpressed in breast and prostate cancers implicated growth aggression tumors. The tumorigenic mechanism underlying EZH2 overexpression largely unknown. It believed that exerts its biological activity as a transcription repressor. However, we report here functions gene transcriptional activation cancer cells. We show transactivates genes are commonly targeted by estrogen Wnt signaling...
Dental pulp/dentin regeneration using dental stem cells combined with odontogenic factors may offer great promise to treat and/or prevent premature tooth loss. Here, we investigate if BMP9 and Wnt/β-catenin act synergistically on differentiation. Using the immortalized SCAPs (iSCAPs) isolated from mouse apical papilla tissue, demonstrate that Wnt3A effectively induces early osteogenic marker alkaline phosphatase (ALP) in iSCAPs, which is reduced by β-catenin knockdown. While enhance each...
A polypyridyl ligand, 2,3,6,7,10,11-hexakis(2-pyridyl)dipyrazino[2,3-f:2',3'-h]quinoxaline (HPDQ), was found to have excellent fluorescent selectivity for Cd(2+) over many other metal ions (K(+), Na(+), Ca(2+), Mg(2+), Mn(2+), Fe(2+), Ni(2+), Co(2+), Cu(2+), Ag(+), Hg(2+), Zn(2+), and Cr(3+)) based on the intramolecular charge-transfer mechanism, which makes HPDQ a potential fluorescence sensor or probe Cd(2+). An obvious color change between + can be visually observed by naked eye. The...
The gut microbiome, a key constituent of the colonic environment, has been implicated as an important modulator human health. eukaryotic epigenome is postulated to respond environmental stimuli through alterations in chromatin features and, ultimately, gene expression. How host mediates epigenomic responses microbiota emerging area interest. Here, we profile microbiome and characteristics colon epithelium from mice fed either obesogenic or control diet, followed by analysis resultant changes...
Coronavirus disease 2019 (COVID-19) is a novel infectious caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan and has quickly spread across world. The mortality rate critically ill patients with COVID-19 high. This study analyzed clinical biochemical parameters between mild patients, helping to identify or critical early.
In our efforts toward rational design and systematic synthesis of 'pillar–layer' structure MOFs, three porous MOFs have been constructed based on [Zn4(bpta)2(H2O)2] (H4bpta = 1,1′-biphenyl-2,2′,6,6′-tetracarboxylic acid) layers different bipyridine pillar ligands. The resulted show similar structures but pore volume window size depending the length ligands which in distinct gas adsorption properties. [Zn4(bpta)2(4,4′-bipy)2(H2O)2]·(DMF)3·H2O (1) (DMF N,N′-dimethylformamide 4,4′-bipy...
The advent of fluorescence-based quantitative real-time PCR (qPCR) has revolutionized the quantification gene expression analysis in many fields, including life sciences, agriculture, forensic science, molecular diagnostics, and medicine. While SYBR Green-based qPCR is most commonly-used platform due to its inexpensive nature robust chemistry, quantifying genes with low abundance or RNA samples extracted from highly restricted limited sources can be challenging because detection sensitivity...
Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) or GDF15 is a divergent member of the transforming growth factor beta (TGF-β) superfamily and mice expressing hNAG-1/hGDF15 have been shown to be resistant HFD-induced obesity inflammation. This study investigated if hNAG-1 increases lifespan in its potential mechanisms. Here we report that female had significantly increased both mean median life spans two transgenic lines, with larger difference on HFD than low fat diet. displayed...
Novel antifungal drugs that evade resistance are urgently needed for Candida infections. Antifungal peptides (AFPs) potential candidates due to their specific mechanism of action, which makes them less prone developing drug resistance. An AFP de novo design method, Deep Learning-Quantitative Structure‒Activity Relationship Empirical Screening (DL-QSARES), is developed by integrating deep learning and quantitative structure‒activity relationship empirical screening. After generating candidate...
Density functional theory is now the method of choice for calculating electronic structure complex systems, and time-dependent density (TDDFT) preferred spectroscopic properties large molecules. The validity depends mainly on quality approximation to unknown exchange–correlation energy. In present paper we consider TDDFT calculations excitation energies oscillator strengths. We show that M06-2X M08-HX functionals perform as well better than range-separated CAM-B3LYP charge transfer...
The TET family of FE(II) and 2-oxoglutarate-dependent enzymes (Tet1/2/3) promote DNA demethylation by converting 5-methylcytosine to 5-hydroxymethylcytosine (5hmC), which they further oxidize into 5-formylcytosine 5-carboxylcytosine. Tet1 is robustly expressed in mouse embryonic stem cells (mESCs) has been implicated mESC maintenance. Here we demonstrate that, unlike genetic deletion, RNAi-mediated depletion mESCs led a significant reduction 5hmC loss identity. differentiation phenotype due...
Structural disruption of gut microbiota is closely related to the occurrence non-alcoholic fatty liver disease (NAFLD). Previous research has demonstrated that both curcumin (CUR) and metformin (MET) have a therapeutic effect against NAFLD play role in modulating microbiota. However, there lack direct comparison between two medications terms efficacy regulatory on In this study, we administered either CUR or MET rats with high-fat diet (HFD)-induced obesity observe changes body parameters,...
Rhizoctonia cerealis is a major fungal pathogen of wheat that causes great yield losses in all wheat-growing regions the world. The biocontrol agent Bacillus subtilis XZ18-3 was investigated for inhibiting R. growth wheat. results mycelial test showed sterile filtrate B. could significantly inhibit and cause swelling rupture mycelium. Observation by transmission electron microscopy indicated penetrate cellular membrane Rhizoctoniacerealis, resulting organelle destruction. effect filtrates on...
Abstract Bacterial wound infections are a serious threat due to the emergence of antibiotic resistance. Herein, we report an innovative hybrid nanozyme independent antibiotics for antimicrobial healing. The nanozymes fabricated from ultra-small Au NPs via in-situ growth on metal-organic framework (MOF)-stabilised Fe 3 O 4 (Fe @MOF@Au NPs, FMA NPs). displayed synergistic peroxidase (POD)-like activities. It showed remarkable level hydroxyl radicals (·OH) in presence low dose H 2 (0.97 mM)....
Immunotherapies comprising programmed cell death protein 1/PD ligand 1 (PD-1/PD-L1) immune checkpoint inhibitors are effective cancer treatments. However, the low response rate and immunoresistance resulting from alternative upregulation inefficient stimulation by T cells problematic. The present report describes a biomimetic nanoplatform that simultaneously blocks T-cell immunoglobulin immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) activates stimulator of interferon genes...