A5049354530- Gut microbiota and health
- Vitamin D Research Studies
- Metabolomics and Mass Spectrometry Studies
- Barrier Structure and Function Studies
- Cancer Research and Treatments
- Statistical Methods and Bayesian Inference
- Salmonella and Campylobacter epidemiology
- Gene expression and cancer classification
- Amyotrophic Lateral Sclerosis Research
- Helicobacter pylori-related gastroenterology studies
- Probiotics and Fermented Foods
- Diet and metabolism studies
- Digestive system and related health
- RNA modifications and cancer
- Viral gastroenteritis research and epidemiology
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- Sleep and related disorders
- Clostridium difficile and Clostridium perfringens research
- Infant Nutrition and Health
- RNA and protein synthesis mechanisms
- Microbial Community Ecology and Physiology
- Bioinformatics and Genomic Networks
University of Illinois Chicago
2016-2025
Shanghai Normal University
2024
Jesse Brown VA Medical Center
2024
Huazhong University of Science and Technology
2024
Union Hospital
2024
University of Chinese Academy of Social Sciences
2024
Chinese Academy of Social Sciences
2024
University of Illinois Urbana-Champaign
2020-2023
Illinois College
2017-2023
Google (United States)
2021
<h3>Objective</h3> Vitamin D and the vitamin receptor (VDR) appear to be important immunological regulators of inflammatory bowel diseases (IBD). Defective autophagy has also been implicated in IBD, where interestingly, polymorphisms genes such as ATG16L1 have associated with increased risk. Although D, microbiome are all involved pathogenesis it remains unclear whether these processes related or function independently. <h3>Design</h3> We investigated effects mechanisms intestinal epithelial...
To evaluate the efficacy of mindfulness meditation for treatment chronic insomnia.Three-arm, single-site, randomized controlled trial.Academic medical center.Fifty-four adults with insomnia.Participants were to either mindfulness-based stress reduction (MBSR), therapy insomnia (MBTI), or an eight-week self-monitoring (SM) condition.Patient-reported outcome measures total wake time (TWT) from sleep diaries, pre-sleep arousal scale (PSAS), measuring a prominent waking correlate insomnia, and...
The in vitro analysis of bacterial-epithelial interactions the intestine has been hampered by a lack suitable intestinal epithelium culture systems. Here, we report new experimental model using an organoid system to study pathophysiology post Salmonella infection. Using crypt-derived mouse organoids, were able visualize invasiveness and morphologic changes organoids. Importantly, reported bacteria-induced disruption epithelial tight junctions infected In addition, showed inflammatory...
Amyotrophic lateral sclerosis (ALS) is a systemic disorder that involves dysfunction of multiple organs. Growing evidence has shown neurodegenerative disorders with gut dysbiosis affect the central nervous system via pro-inflammatory mediators thus impacting gut-brain communications. We have demonstrated and increased intestinal permeability in SOD1G93A ALS mouse model. In this study, we comprehensively examined human microbiome stool samples evaluated infection markers inflammation five...
After the initiation of Human Microbiome Project in 2008, various biostatistic and bioinformatic tools for data analysis computational methods have been developed applied to microbiome studies. In this review perspective, we discuss research statistical hypotheses gut studies, focusing on mechanistic concepts that underlie complex relationships among host, microbiome, environment. We current available statistic highlight recent progress newly models. Given challenges limitations approaches...
Salmonella infections can become chronic and increase the risk of cancer. The mechanisms by which specific organisms contribute to cancer, however, are still unknown. Live attenuated used as vectors target cancer cells, but there have been no systematic studies oncogenic potential in models. AvrA, a pathogenic product Salmonella, is inserted into host cells during infection influences eukaryotic cell pathways. In current study, we colonized mice with AvrA-sufficient or AvrA-deficient...
This study uses National Violence against Women Survey data to investigate the differential impact of concomitant forms violence (sexual abuse, stalking, and psychological abuse) ethnicity on help-seeking behaviors women physically abused by an intimate partner (n = 1,756). Controlling for severity physical who experienced sexual abuse are less likely seek help, stalking more whereas is not associated with help seeking. Ethnic differences found in seeking from friends, mental health...
Low expression of vitamin D receptor (VDR) and dysfunction D/VDR signaling are reported in patients with inflammatory bowel disease (IBD); therefore, restoration VDR function to control inflammation IBD is desirable. Probiotics have been used the treatment IBD. However, role probiotics modulation effectively reduce unknown. We identified a novel activating activity, thus inhibiting inflammation, using cell models knockout mice. found that Lactobacillus rhamnosus strain GG (LGG) plantarum...
The advent of fluorescence-based quantitative real-time PCR (qPCR) has revolutionized the quantification gene expression analysis in many fields, including life sciences, agriculture, forensic science, molecular diagnostics, and medicine. While SYBR Green-based qPCR is most commonly-used platform due to its inexpensive nature robust chemistry, quantifying genes with low abundance or RNA samples extracted from highly restricted limited sources can be challenging because detection sensitivity...
Background & AimsVitamin D exerts regulatory roles via vitamin receptor (VDR) in mucosal immunity, host defense, and inflammation involving factors microbiome. Human Vdr gene variation shapes the microbiome VDR deletion leads to dysbiosis. Low expression diminished D/VDR signaling are observed colon cancer. Nevertheless, how intestinal epithelial is involved tumorigenesis through gut microbiota remains unknown. We hypothesized that protects mice against dysbiosis modulating Janus kinase...
Tight junctions are essential for barrier integrity, inflammation, and cancer. Vitamin D the vitamin receptor (VDR) play important roles in colorectal cancer (CRC). Using human CRC database, we found colonic VDR expression was low significantly correlated with a reduction of Claudin-5 mRNA protein. In colon VDRΔIEC mice, deletion intestinal led to lower protein levels Claudin-5. Intestinal permeability increased VDR-/- model. Lacking associated an number tumors mice. Furthermore, gain loss...
Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. The ALS mice expressing human mutant of transactive response DNA binding protein 43 kDa (hmTDP43) showed intestinal dysfunction before symptoms. We hypothesize that restoring the and microbial homeostasis with bacterial metabolite or probiotics delays disease onset. investigate pathophysiological changes in intestine neurons, blood–brain barriers, inflammation during progression. then cultured enteric glial cells (EGCs) isolated...
Salmonella Typhimurium is a major cause of human gastroenteritis. The type III secretory system secretes virulence proteins, called effectors. Effectors are responsible for the alteration tight junction (TJ) structure and function in intestinal epithelial cells. AvrA newly described bacterial effector found Salmonella. We report here that expression stabilizes cell permeability junctions Cells colonized with an AvrA-deficient strain (AvrA-) displayed decreased permeability, disruption TJs,...