A5100772293- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Urban Heat Island Mitigation
- Cardiac Imaging and Diagnostics
- Functional Brain Connectivity Studies
- Cardiac Valve Diseases and Treatments
- Urban Green Space and Health
- Cardiac electrophysiology and arrhythmias
- Advanced Neuroimaging Techniques and Applications
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Tendon Structure and Treatment
- ECG Monitoring and Analysis
- Osteoarthritis Treatment and Mechanisms
- Lung Cancer Treatments and Mutations
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Natural product bioactivities and synthesis
- Heart Failure Treatment and Management
- Acute Myeloid Leukemia Research
- Advanced MRI Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Venous Thromboembolism Diagnosis and Management
Northwest A&F University
2019-2025
Second Affiliated Hospital of Nanjing Medical University
2018-2025
Nanjing University
2014-2025
Chang Gung University
2015-2025
Chang Gung Memorial Hospital
2016-2025
Hubei University of Chinese Medicine
2020-2025
Fujian Electric Power Survey & Design Institute
2022-2025
Wuhan University of Science and Technology
2025
Ministry of Agriculture and Rural Affairs
2025
China Agricultural University
2025
Middle East respiratory syndrome coronavirus (MERS-CoV) and several bat coronaviruses use dipeptidyl peptidase-4 (DPP4) as an entry receptor1-4. However, the receptor for NeoCoV-the closest known MERS-CoV relative found in bats-remains unclear5. Here, using a pseudotype virus assay, we that NeoCoV its close relative, PDF-2180, can efficiently bind to specific angiotensin-converting enzyme 2 (ACE2) orthologues and, less favourably, human ACE2 receptors through their receptor-binding domains...
Abstract Background and Aims Valve interstitial cells (VICs) undergo a transition to intermediate state before ultimately transforming into the osteogenic cell population, which is pivotal cellular process in calcific aortic valve disease (CAVD). Herein, this study successfully delineated stages of VIC transformation elucidated novel key regulatory role lumican (LUM) process. Methods Single-cell RNA-sequencing (scRNA-seq) from nine human valves was used characterize pathological switch...
Lactate plays a critical role as an energy substrate, metabolite, and signaling molecule in hepatocellular carcinoma (HCC). Intracellular lactate-derived protein lysine lactylation (Kla) is identified contributor to the progression of HCC. Liver cancer stem cells (LCSCs) are believed be root cause phenotypic functional heterogeneity However, impact Kla on biological processes LCSCs remains poorly understood. Here enhanced glycolytic metabolism, lactate accumulation, elevated levels observed...
Abstract Background and Purpose Our previous studies have found that andrographolide (AGP) alleviates calcific aortic valve disease (CAVD), but the underlying mechanism is unclear. This study explores molecular target signal mechanisms of AGP in inhibiting CAVD. Experimental Approach The anti‐calcification effects with treatment were evaluated by alizarin red staining vitro ultrasound histopathological assessment a high‐fat (HF)‐fed ApoE −/− mouse calcification model. A correlation between...
Objective: Leaflet thickening, fibrosis, and hardening are early pathological features of calcific aortic valve disease (CAVD). An inadequate understanding the resident cells involved in process may compromise development therapeutic strategies. We aim to construct a pattern human cell atlas healthy CAVD clinical specimens, providing insight into cellular origins complex cytopathological differentiation process. Approach Results: used unbiased single-cell RNA sequencing for high-throughput...
Plants use both cell surface-resident pattern recognition receptors (PRRs) and intracellular nucleotide binding leucine-rich repeat (NLR) to detect various pathogens. Plant PRRs typically recognize conserved pathogen-associated molecular patterns (PAMPs) provide broad-spectrum resistance. By contrast, plant NLRs generally pathogen strain-specific effectors confer race-specific Here, we demonstrate that the tomato (Solanum lycopersicum) NLR Sw-5b confers resistance against American-type...
Cartilage injury affects numerous individuals, but the efficient repair of damaged cartilage is still a problem in clinic. Hydrogel potent scaffold candidate for tissue regeneration, it remains big challenge to improve its mechanical property and figure out interaction chondrocytes stiffness. Herein, novel hybrid hydrogel with tunable stiffness was fabricated based on methacrylated gelatin (GelMA) iron oxide nanoparticles (Fe2O3) through chemical bonding. The Fe2O3/GelMA controlled by...
Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression, yet how this process is regulated by oncogenic signal remains largely unknown. Here, we unveil that non-canonical activation nuclear AURKA promotes an suppressor RBM4 directed m6A reader YTHDC1 in lung cancer. Nuclear translocation a prerequisite for aberrant splicing, specifically triggering from the full isoform (RBM4-FL) short (RBM4-S) kinase-independent manner. RBM4-S functions as promoter...