A5084064209- Traditional Chinese Medicine Studies
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Neurological Disease Mechanisms and Treatments
- Medicinal Plant Pharmacodynamics Research
- Healthcare and Venom Research
- Medical Research and Treatments
- Flavonoids in Medical Research
- Plant-based Medicinal Research
- Phytoestrogen effects and research
- Phytochemistry and Biological Activities
- Biochemical effects in animals
- Ginseng Biological Effects and Applications
- Food Allergy and Anaphylaxis Research
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytochemistry and biological activity of medicinal plants
- Acupuncture Treatment Research Studies
- Metabolomics and Mass Spectrometry Studies
- Seaweed-derived Bioactive Compounds
- Cancer-related molecular mechanisms research
- Natural Antidiabetic Agents Studies
- Ziziphus Jujuba Studies and Applications
- Nanoplatforms for cancer theranostics
- Andrographolide Research and Applications
First Affiliated Hospital of Henan University
2016-2025
Henan University of Traditional Chinese Medicine
2011-2023
Scripps Research Institute
2023
University of California, Los Angeles
2023
University of Utah
2023
Indian Institute of Technology Kharagpur
2023
Henan University
2021
Bio-Rad (United States)
2018
University of Hong Kong
2018
IS Instruments (United Kingdom)
2018
Icariin is a prenylated flavonol glycoside isolated from Epimedium herb, and has been shown to be its main bioactive component. Recently, the antidepressant-like mechanism of icariin increasingly evaluated demonstrated. However, there are few studies that have focused on involvement phosphatidylinositol 3-kinase (PI3K)/serine-threonine protein kinase (AKT) signaling in mediating perimenopausal depression effects icariin. Perimenopausal chronic recurrent disease leads an increased risk...
The novel coronavirus disease, COVID-19, has grown into a global pandemic and major public health threat since its breakout in December 2019. To date, no specific therapeutic drug or vaccine for treating COVID-19 SARS been FDA approved. Previous studies suggest that berberine, an isoquinoline alkaloid, shown various biological activities may help against SARS, including antiviral, anti-allergy inflammation, hepatoprotection drug- infection-induced liver injury, as well reducing oxidative...
We screened seaweed species from Atlantic Canada for antidiabetic activity by testing extracts α-glucosidase inhibitory effect and glucose uptake stimulatory activity. An aqueous ethanolic extract of Ascophyllum nodosum was found to be active in both assays, inhibiting rat intestinal (IC 50 = 77 μg/mL) stimulating basal into 3T3-L1 adipocytes during a 20-minute incubation about 3-fold (at 400 μg/mL extract). Bioassay-guided fractionation the A. showed that inhibition associated with...
There is a lack of evidence on the effectiveness postnatal depression (PND) screening programmes in reducing morbidity. The aim this study was to evaluate PND programme using Edinburgh Postnatal Depression Scale (EPDS) improving maternal mental health.The randomized controlled trial design used. Participants were 462 Chinese mothers with 2-month-old babies visiting Maternal and Child Health Centres Hong Kong. intervention group screened for EPDS, whereas those control by clinical assessment....
Postoperative tumor recurrence remains a predominant cause of treatment failure. In this study, we developed an in situ injectable hydrogel, termed MPB-NO@DOX + ATRA gel, which was locally formed within the resection cavity. The gel fabricated by mixing thrombin solution, fibrinogen solution containing all-trans retinoic acid (ATRA), and Mn/NO-based immune nano-activator MPB-NO@DOX. promoted differentiation cancer stem cells, inhibited cell migration, affected polarization tumor-associated...
To study the therapeutic mechanism of Tuihuang Mixture against cholestasis. Forty-eight Wistar rats were randomized equally into blank group, model ursodeoxycholic acid group and group. Except for those in all given α‑naphthylisothiocyanate (ANIT) to establish rat models cholestasis, followed by treatments with indicated drugs or distilled water. Serum levels ALT, AST, ALP, γ-GT, TBA TBIL determined, hepatic expressions IL-1β, IL-18, FXR, NLRP3, ASC, Caspase-1 GSDMD detected using q-PCR,...
Quercetin (Que) is one of main compounds in Lysimachia christinae Hance (Christina loosestrife), and has both medicinal nutritional value. Glycosides from Tripterygium wilfordii Hook.f. (léi gōng téng [the thunder duke vine]; TG) have diverse broad bioactivities but with a high incidence liver injury. Our previous study reported on the hepatoprotective properties an ethanol extract L. against TG-induced injury mice. This research designed to observe, for first time, possible protective...
Food allergy-induced autism-like behavior has been increasing for decades, but the causal drivers of this association are unclear. We sought to test gut microbiota and mammalian/mechanistic target rapamycin (mTOR) signaling with cow's milk allergy (CMA)-induced autism pathogenesis.Mice were sensitized intragastrically whey protein containing cholera toxin before sensitization on intraperitoneal injection whey-containing alum, followed by intragastric allergen challenge induce experimental...
Introduction Food allergy is a significant public health problem with limited treatment options. As Allergy Herbal Formula 2 (FAHF-2) showed potential as food treatment, we further developed purified version named EBF-2 and identified active compounds. We investigated the mechanisms of on IgE-mediated peanut (PN) its compound, berberine, IgE production. Methods plasma cell line U266 cells were cultured FAHF-2, their effects production compared. was evaluated in murine PN model for effect...
Goals To assess the efficacy and safety of Chinese Medicine Prescription “W-LHIT” in subjects with simple obesity, to explore its potential mechanism action. Methods Thirty-seven patients aged 18 60 from Wei-En hospital (Weifang City, Shandong, China), participated a double blinded, placebo-controlled study. Subjects were randomly divided into 2 groups, treatment 19 placebo group. The group took capsules for two months, while control received capsules. Both groups accepted healthy lifestyle...
Ischemic stroke is one of the most common causes mortality worldwide and a primary cause disability in adults. There an unmet need for drugs that can effectively treat ischemic stroke. Hence, present study explored neuroprotective effects andrographolide (Andro) mouse model bilateral carotid artery occlusion, systematically evaluated potential mechanisms underlying its effects. The Andro on brain tissue following cerebral ischemia‑reperfusion injury (CIRI) were by histopathological (H&E...
Perilla frutescens (PF) leaf is a traditional Chinese medicine and food with beneficial effects on allergic asthma. We sought to elucidate the active compounds, targets, underlying mechanisms of PF in treatment asthma by using experimental pharmacology network pharmacology. An OVA-allergic murine model was constructed evaluate effect And western blotting were performed its significantly improved lung function OVA mice mitigated injury reducing OVA-specific immunoglobulin E serum, interleukin...
Background Gut microbiota influence food allergy. We showed that the natural compound berberine reduces IgE and others reported BBR alters gut implying a potential role for changes in function. Objective sought to evaluate an oral Berberine-containing medicine with boiled peanut immunotherapy (BNP) regimen as treatment allergy using murine model explore correlation of treatment-induced therapeutic outcomes. Methods Peanut-allergic (PA) mice, orally sensitized roasted cholera toxin, received...
Effective diagnosis and therapy for bacterial infections, especially those caused by multidrug-resistant (MDR) species, greatly challenge current antimicrobial stewardship. Monocytes, which can chemotactically migrate from the blood to infection site elicit a robust infiltration, provide golden opportunity theranostics. Here, nano-Trojan Horse was facilely engineered using mannose-functionalized manganese-eumelanin coordination nanoparticles (denoted as MP-MENP) precise two-step localization...
Observe anti-inflammatory effect and the on acute pharyngitis rats model induced by ammonia water of compound Lobelia oral liquid, providing experimental basis for its clinical use. Use egg white establish foot swelling use carboxymethyl cellulose blood cell migration model. Then observe liquid. 15% spray at pharyngeal model, Visual observation conduct grading tissue stimulation in rats, measure levels TNF-α IL-6 serum. Pharyngeal was taken to morphological changes. All dose groups liquid...
The effect of the Rabdosia rubescens total flavonoids on focal cerebral ischemia reperfusion model in rats was observed. group, nimodipine collateral and large, medium small dose group were administered with corresponding drugs but sham operation same volume 0.5%CMC, 1 times a day, continuous administration 7 d. After h at d to medicine, left incision middle neck after anesthesia, we can firstly expose isolate common carotid artery (CCA), then external (ECA) internal (ICA). are ligated. Then...
Objective: The aim of this study is to investigate the effects a Fuzheng Paidu tablet on peripheral blood T lymphocytes, intestinal mucosa and immune organs in cyclophosphamide (CY)-induced immunosuppressed mice. Methods: experimental mice (but not control mice) were intraperitoneally injected with 80 mg/kg CY solution every day for 3 consecutive days. Meanwhile, each mouse was administered corresponding drugs 7 continuous Then, 1 h after last administration, index detected. Results:...
Melanoma is a highly aggressive form of skin cancer with rapidly increasing incidence. New strategies are urgently needed for treating advanced melanoma which closely linked to metastasis and often results in death. The Src-ERK signaling axis contributes significantly both cell growth metastasis. Triptolide,
The aim of this study was to observe the treatment characteristics verbenalin on a prostatitis mouse model. Give Xiaozhiling injection in prostate locally make High, medium and low doses were each given different groups. amount water determined 14th, 28th. number white cells lecithin corpuscle density prostatic fluid determined. Morphological changes prostate, testis, epididymis kidney detected. Compared with model control group, mice treated high, had significantly increased amounts water,...
This paper aims to observe the effects of total flavonoids Radix Ilicis pubescentis on mouse model cerebral ischemia reperfusion. Mice were orally given different doses 10 d, and administered once daily. On tenth day after administration 1 h in mice anesthesia, we used needle hook bilateral common carotid artery (CCA) for min, with min reperfusion, ischemia. Then restored their blood supply, copy reperfusion; We then had all reperfused 24 h, took orbital samples measured rheology. quickly...