Melatonin, a pleiotropic signal molecule, has been shown to play important roles in the regulation of plant growth, development, and responses environmental stresses. Since few species have investigated unveil effect exogenous melatonin on salt stress, underlying mechanism melatonin-mediated stress tolerance other still remains largely unknown. In this study, effects leaf photosynthesis redox homeostasis watermelon were examined under (300 mM NaCl) along with different doses (50, 150, 500...

Drought stress has become an increasingly serious environmental issue that influences the growth and production of watermelon. Previous studies found arbuscular mycorrhizal (AM) colonization improved fruit yield water use efficiency (WUE) watermelon grown under stress; however, exact mechanisms remain unknown. In this study, effects Glomus versiforme symbiosis on growth, physio-biochemical attributes, stress-responsive gene expressions seedlings well-watered drought conditions were...

Abstract Root–shoot communication has a critical role in plant adaptation to environmental stress. Grafting is widely applied enhance the abiotic stress tolerance of many horticultural crop species; however, signal transduction mechanism involved this remains unknown. Here, we show that pumpkin- or figleaf gourd rootstock-enhanced cold watermelon shoots accompanied by increases accumulation melatonin, methyl jasmonate (MeJA), and hydrogen peroxide (H 2 O ). Increased melatonin levels leaves...

Brain metastasis (BM) is associated with poor prognosis, recurrence, and death in patients non-small cell lung cancer (NSCLC). Lysophosphatidylcholine acyltransferase 1 (LPCAT1) has been reported to be involved the progression, recurrence of malignancies. However, potential role LPCAT1 NSCLC remains poorly understood. This study was aimed identify genes adenocarcinoma (LUAD) brain metastasis, look into LUAD progression.We used integrative genomic analysis adenocarcinomas. expression...

Abstract Melatonin is a ubiquitous chemical substance that regulates plant growth and responses to stress. Several recent studies show exogenous melatonin confers cold tolerance plants; however, the underlying mechanisms remain largely unknown. Here, we report application at optimal dose, either on leaves or roots, not only induced stress in site of application, but also systemically untreated distant parts. Foliar rhizospheric treatment with increased levels roots leaves, respectively,...

Abstract Melatonin is a pleiotropic signaling molecule that regulates plant growth and responses to various abiotic stresses. The last step of melatonin synthesis in plants can be catalyzed by caffeic acid O -methyltransferase (COMT), multifunctional enzyme reported have N -acetylserotonin (ASMT) activity; however, the ASMT activity COMT has not yet been characterized nonmodel such as watermelon ( Citrullus lanatus ). Here, total 16 putative O-methyltransferase ClOMT ) genes were identified...

Chitinases, which catalyze the hydrolysis of chitin, primary components fungal cell walls, play key roles in defense responses, symbiotic associations, plant growth, and stress tolerance. In this study, 23 chitinase genes were identified watermelon (Citrullus lanatus [Thunb.]) classified into five classes through homology search phylogenetic analysis. The with similar exon-intron structures conserved domains clustered same class. putative cis-elements involved responses to phytohormone,...

Mesenchymal to epithelial transition factor (MET) dysregulation in non-small-cell-lung-cancer (NSCLC) is understudied, with scant data on treatment outcomes. We retrospectively examined 160 NSCLC patients: 125 primary MET mutations (further classified into exon 14 (METex14) skipping and amplifications) 35 secondary amplifications. Patients underwent varied treatments: Chemotherapy, Immune monotherapy, Crizotinib, or Savolitinib. Secondary amplification patients were grouped by treatment:...

Abstract Melatonin is involved in defending against oxidative stress caused by various environmental stresses plants. In this study, the roles of exogenous melatonin regulating local and systemic defense photooxidative cucumber ( Cucumis sativus ) involvement redox signaling were examined. Foliar or rhizospheric treatment with enhanced tolerance to both melatonin‐treated leaves untreated leaves. Increased levels are capable increasing glutathione (reduced [ GSH ]) status. Application H 2 O...

Abstract Background Brain metastasis (BM) is associated with poor prognosis in patients non-small cell lung cancer (NSCLC). Recent studies demonstrated that microRNA-330-3p (miR-330-3p) was involved NSCLC brain (BM). However, the exact parts played by miR-330-3p BM of remain unknown. Discovery and development biomarkers elucidation mechanism underlying critical for effective prophylactic interventions. Here, we evaluated expression biological effects cells explored promoting migration...

Acetylcholine (ACh) is believed to improve plant growth. However, regulation at biochemical and molecular levels largely unknown. The present study investigated the impact of exogenously applied ACh (10 µm) on growth chlorophyll metabolism in hydroponically grown Nicotiana benthamiana under salt stress (150 mm NaCl). Salinity reduced root hydraulic conductivity while ACh-treated seedlings exhibited a significant increase, resulting increased relative water content. induced reduction...

Transcriptional regulation of cold-responsive genes is crucial for exogenous melatonin-mediated cold tolerance in plants. Nonetheless, how melatonin regulates largely unknown. In this study, we found that improved watermelon by regulating expression microRNAs (miRNAs). We identified a set miRNAs were regulated under unstressed or conditions. Importantly, mRNA-seq analysis revealed melatonin-induced downregulation some miRNAs, such as miR159-5p, miR858, miR8029-3p, and novel-m0048-3p...

Despite identification of WRKY family genes in numerous plant species, a little is known about watermelon, one the most economically important fruit crops around world. Here, we identified total 63 putative watermelon and classified them into three major groups (I-III) five subgroups (IIa-IIe) group II. The structure analysis indicated that ClWRKYs with different domains or motifs may play roles by regulating respective target genes. expressions tissues indicate they are involved various...

Abstract The yellow peach moth (YPM), Conogethes punctiferali s (Guenée), is a multivoltine insect pest of crops and fruits. Antennal-expressed receptors are important for insects to detect olfactory cues host finding, mate attraction oviposition site selection. However, few related genes were reported in YPM until now. In the present study, we sequenced characterized antennal transcriptomes male female YPM. total, 15 putative odorant binding proteins (OBPs), 46 (ORs) 7 ionotropic (IRs)...

Brain metastasis (BM) is associated with poor prognosis in patients non-small cell lung cancer (NSCLC).We sought to identify microRNAs (miRNAs) that could serve as biomarkers differentiate NSCLC and without BM.Logistic regression was conducted 122 (60 BM, 62 BM) assess the association between miRNAs BM.We confirmed several risk factors for BM revealed serum miR-330-3p levels are higher than BM.Overexpression of promoted proliferation, migration, invasion epithelial-mesenchymal transition...

Cold stress is a major environmental factor that detrimentally affects plant growth and development. Melatonin has been shown to confer tolerance cold through activating the C-REPEAT BINDING FACTOR (CBF) pathway; however, underlying modes enable this function remain obscure. In study, we investigated role of H2O2 Ca2+ signaling in melatonin-induced CBF pathway watermelon (Citrullus lanatus L.) pharmacological, physiological, genetic approaches. According results, melatonin induced...

Precocious leaf senescence can reduce crop yield and quality by limiting the growth stage. Melatonin has been shown to delay senescence; however, underlying mechanism remains obscure. Here, we show that melatonin offsets abscisic acid (ABA) protect photosystem II of attached old leaves under light. induced H2 O2 accumulation accompanied an upregulation melon respiratory burst oxidase homolog D (CmRBOHD) ABA-induced stress. Both cytoplasmic-free Ca2+ ([Ca2+ ]cyt ) in response ABA, while...

Background: This study aims to determine the efficacy and safety profile of aumolertinib in real-word treatment setting for advanced non-small-cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor (EGFR) mutations. Methods: We retrospectively analyzed clinical data 173 EGFR-mutated NSCLC who received at Henan Cancer Hospital from April 2020 December 2022. Progression-free survival (PFS) overall (OS) were evaluated using Kaplan–Meier curves, while a Cox regression model...

Aqueous batteries, such as aqueous zinc-ion batteries (AZIB), have garnered significant attention because of their advantages in intrinsic safety, low cost, and eco-friendliness. However, electrolytes tend to freeze at temperatures, which limits potential industrial applications. Thus, one the core challenges electrolyte design is optimizing formula prevent freezing while maintaining good ion conductivity. experimental trial-and-error approach inefficient for this purpose, existing...