A5103171025- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- Bone Metabolism and Diseases
- Sepsis Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Cancer Immunotherapy and Biomarkers
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- interferon and immune responses
- Sirtuins and Resveratrol in Medicine
- Frailty in Older Adults
- Gastrointestinal motility and disorders
- Liver physiology and pathology
- Heavy Metal Exposure and Toxicity
- Adsorption and biosorption for pollutant removal
- Natural Fiber Reinforced Composites
- Trace Elements in Health
- Osteoarthritis Treatment and Mechanisms
- Cancer therapeutics and mechanisms
- Autophagy in Disease and Therapy
- Nutrition and Health in Aging
- Lower Extremity Biomechanics and Pathologies
- COVID-19 and healthcare impacts
- Inflammatory Myopathies and Dermatomyositis
The First Affiliated Hospital, Sun Yat-sen University
2009-2025
Sun Yat-sen University
2009-2025
Gansu University of Traditional Chinese Medicine
2022-2024
Nanjing University of Chinese Medicine
2023-2024
Zhengzhou University
2018-2024
Henan Cancer Hospital
2018-2024
Nanjing University
2023
Ningxia Medical University
2021
Background: This study aims to determine the efficacy and safety profile of aumolertinib in real-word treatment setting for advanced non-small-cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor (EGFR) mutations. Methods: We retrospectively analyzed clinical data 173 EGFR-mutated NSCLC who received at Henan Cancer Hospital from April 2020 December 2022. Progression-free survival (PFS) overall (OS) were evaluated using Kaplan–Meier curves, while a Cox regression model...
The health implications of trace elements have become increasingly concerning, yet the connection between blood manganese levels and anemia remains insufficiently examined. This research endeavors to explore potential linkage concentrations anemia. Utilizing data from National Health Nutrition Examination Survey (NHANES) 2011 2018, this study examines correlation among U.S. adults, offering a comprehensive national perspective. included 11,300 adults aged 20 above, with both hemoglobin...
To investigate the influence of mutation abundance and sites epidermal growth factor receptor (EGFR) on therapeutic efficacies EGFR-tyrosine kinase inhibitor (EGFR-TKIs) treatments patients with advanced non-small cell lung carcinoma (NSCLC).EGFR mutational were analyzed by amplification refractory system (ARMS) in paraffin-embedded tissue sections taken from primary or metastatic tumors 194 NSCLC patients.The median progression-free survival (PFS) time enrolled was 9.3 months (95% CI,...
To explore the easily applicable indicators of practical value to evaluate prognosis acute respiratory distress syndrome (ARDS).Blood and biochemical tests blood-gas analyses were performed upon entry into ICUs, 12 h, 24 48 h 72 after that in ARDS patients (who admitted ICUs our hospital from January 2000 December 2009). Then APACHE II scores achieved by combining relevant physiological parameters laboratory results.There was a statistical difference between death group survival at different...
Nutritional status is related to the clinical outcomes of patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD). The aim this study was investigate association between nutritional status, measured by prognostic index (PNI), and adverse hospitalization in AECOPD.Consecutive AECOPD admitted First Affiliated Hospital Sun Yat-sen University January 1, 2015 October 31, 2021 were enrolled. We collected characteristics laboratory data patients. Multivariable logistic...
Abstract This was a single-arm, multicenter phase 2 clinical trial (ChiCTR1900021726) involving advanced squamous non-small cell lung cancer (sq-NSCLC) patients undergoing cycles of nab-paclitaxel/carboplatin and sintilimab (anti-PD-1), followed by maintenance therapy. The median progression-free survival (PFS) 11.4 months (95% CI: 6.7-18.1), which met the pre-specified primary endpoint. Secondary endpoints included objective response rate reaching 70.5% disease control 93.2%, with duration...
To investigate the mechanism by which Peitu Yifei Granules inhibit idiopathic pulmonary fibrosis(IPF) in rats, fifty specific-pathogen-free(SPF) grade male Wistar rats were randomly divided into blank group and modeling group. IPF was induced tracheal infusion of 5 mg·kg~(-1) bleomycin(BLM) then model group, pirfenidone high-dose, medium-dose, low-dose groups treated with Granules. After 24 hours modeling, treatment received intragastric administration either or as a positive control drug;...
Early identification of patients with novel corona virus disease 2019 (COVID-19) who may be at high mortality risk is great importance. In this retrospective study, we included all COVID-19 Huanggang Central Hospital from January 23 to March 5, 2020. Data on clinical characteristics and outcomes were compared between survivors nonsurvivors. Univariable multivariable logistic regression used explore factors associated in-hospital death. A nomogram was established based the selected by...
Abstract Objectives Mesenchymal stromal cells in muscles participate regeneration following muscle injury. This study explored the potential of [18F]fibroblast activation protein inhibitor (FAPI)-42 PET targeting mesenchymal to evaluate disease activity idiopathic inflammatory myopathy (IIM). Methods Patients with IIM (n = 26) were prospectively included and underwent [18F]FAPI-42 PET/CT whole-body MRI between January 2023 July 2023. malignancies retrospectively control group only 28)....
Anti-melanoma differentiation-associated protein 5 antibody-positive dermatomyositis (anti-MDA5-positvie DM) is a subtype of with poor prognosis, characterized by rapidly progressive interstitial lung disease (RP-ILD). The study aims to investigate the significance serum cytokines profiles and peripheral lymphocytes in predicting prognoses anti-MDA5-positvie DM RP-ILD. Furthermore, it seeks analyze longitudinal data during hospitalization identify distinct trajectories cluster patients...
Previous studies have shown that the red cell index (RCI) can be considered as a simple and useful method to evaluate respiratory function. However, at present its association with adverse hospitalization outcomes in patients acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is not fully understood. Our study aimed examine relationship between RCI among AECOPD patients.We performed retrospective analysis consecutive from January 2015 October 2021. In this study, was...
Introduction Severe postintubation tracheal stenosis (PITS) is a rare iatrogenic complication after endotracheal intubation.Case presentation A case of PITS in 51-year-old male undergoing partial pericardiectomy with principal diagnosis tuberculous constrictive pericarditis. Within 6 hours extubation, second emergency intubation lasting 120 was performed. The patient reported exertional dyspnea 30 days discharge. High-resolution tracheobronchial tree computed tomography three-dimensional...
Abstract Objective: To explore whether EGFR-TKI combined with chemotherapy would benefit patients advanced lung adenocarcinoma both sensitive EGFR mutation and concomitant non-EGFR genetic alterations. Materials Methods: Cases of alterations were retrospectively collected. And the required to receive first-line combination or monotherapy. Demographic, clinical pathological data collected, electronic imaging retrieved evaluate efficacy time disease progression. Survival obtained through...
Abstract Background : Patients with osteoarthritis have musculoskeletal-related chronic disability, leading to the high pain intensity. Explaining molecular mechanisms of is critial for diagnosis and cure. Therefore, This research aimed find key candidate genes involved in pathogenesis. Methods We identified differentially expressed by integrating multiple microarry datasets cartilage (GSE43923, GSE113825, GSE129147 GSE169077). Functional enrichment analysis protein-protein interaction were...
The application of vegetable oil-based softeners canola oil and cottonseed in Solution polymerized styrene-butadiene rubber (SSBR) system composites was investigated. results showed that when the aromatic replaced by 5 parts equal amounts base formulation SSBR system, working performance better, tear strength elongation at break were improved tensile reduced; vulcanization time prepared with significantly reduced compared oil; glass transition temperature cold resistance snow improved.
Background: Consensus on the most reliable assays to detect invasive aspergillosis from minimally or noninvasive samples has not been reached. In this study, we compared efficacy of an enzyme-linked immunosorbent assay (ELISA) for galactomannan (GM) detection and quantitative real-time PCR (qRT-PCR) diagnosis pulmonary in a rat model. Methods: Neutropenic, male Sprague-Dawley rats (specific pathogen free; 8 weeks old; weight, 200 ± 20 g) were immunosuppressed with cyclophosphamide infected...
Abstract Background Promoting osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is the main therapeutic goal for postmenopausal osteoporosis (PMOP). Recently, several long non-coding RNAs (lncRNAs) have been reported to be involved in PMOP; however, role lncRNA tissue inhibitor metalloproteinases 3 (lncTIM3) remains investigated. Methods The characteristics BMSCs isolated from PMOP rat model were verified by flow cytometry assay, alkaline phosphatase (ALP), alizarin...