A5100624562- Bone Metabolism and Diseases
- Immune cells in cancer
- Retinoids in leukemia and cellular processes
- Osteoarthritis Treatment and Mechanisms
- MicroRNA in disease regulation
- Acute Myeloid Leukemia Research
- Bone health and treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Biomarkers in Disease Mechanisms
- Spinal Cord Injury Research
- Immune Response and Inflammation
- Antioxidant Activity and Oxidative Stress
- Histone Deacetylase Inhibitors Research
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- RNA modifications and cancer
- Bladder and Urothelial Cancer Treatments
- Silk-based biomaterials and applications
- Arsenic contamination and mitigation
- Nanocomposite Films for Food Packaging
- Caveolin-1 and cellular processes
- TGF-β signaling in diseases
Nanjing University of Chinese Medicine
2018-2025
Center for Rheumatology
2025
Western Sydney University
2021-2024
Shanghai Institute of Hematology
2014-2024
Ruijin Hospital
2016-2024
Shanghai Jiao Tong University
2014-2024
Guangdong Academy of Sciences
2024
Guangxi University of Chinese Medicine
2009-2024
Northwest A&F University
2023
Institute of Biophysics
2023
Quercetin, a flavonoid found in natural medicines, has shown role disease prevention and health promotion. Moreover, because of its recently identified contribution regulating bone homeostasis, quercetin may be considered promising agent for improving health. This study aimed to elucidate the androgen deprivation therapy-induced osteoporosis mice. C57BL/6 mice were subjected orchiectomy, followed by treatment (75 150 mg/kg/d) 8 weeks. Bone microstructure was then assessed micro-computed...
Immune inflammatory responses play an important role in spinal cord injury (SCI); however, the beneficial and detrimental effects remain controversial. Many studies have described of neutrophils, macrophages, T lymphocytes immune after SCI, although little is known about B lymphocytes, immunosuppression can easily occur SCI.A mouse model SCI was established, HE staining Nissl were performed to observe pathological changes. The size morphology spleen examined, on function cell levels detected...
Accumulating evidence has demonstrated that aberrant expression of deubiquitinating enzymes is associated with the initiation and progression Triple-negative breast cancer (TNBC). The publicly available TCGA database data was used to analyze OTUD family members were correlated survival ovarian tumor domain-containing 2 (OTUD-2), or YOD1 identified. aim present study assess function in human TNBC then explored underlying molecular events. We detected 32 44 NTNBC samples by qRT-PCR, Western...
Abstract Background Phenylalanine ammonia-lyase (PAL, EC 4.3.1.24) is the first key enzyme in phenylpropanoid pathway. The pal gene has been widely studied plants and participates plant growth, development defense systems. However, Pleurotus ostreatus , biological functions of during organismal exposure to abiotic stress have not reported. Results In this study, we cloned characterized pal1 (2232 bp) pal2 (2244 genes from basidiomycete P. CCMSSC 00389. are interrupted by 6 10 introns,...
Macrophages play an essential role in the pathogenesis of most inflammatory diseases. Recent studies have shown that mechanical load can influence macrophage function, leading to excessive and uncontrolled inflammation even systemic damage, including cardiovascular disease knee osteoarthritis. However, molecular mechanism remains unclear. In this study, murine RAW264.7 cells were treated with stretch (MS) using Flexcell-5000T Tension System. The expression factors cytokine release measured...
<title>Abstract</title> Background Severe residual back pain (RBP) after percutaneous kyphoplasty (PKP) significantly impacts postoperative prognosis and quality of life in patients. This study aims to identify the risk factors for RBP patients with osteoporotic vertebral compression fractures (OVCF) following PKP, establish validate a prediction model occurrence so as deepen our understanding improve clinical management strategies. Methods 647 OVCF who had PKP surgery from 2018 2020 were...
<title>Abstract</title> Background Recent research has identified CD31<sup>hi</sup>EMCN<sup>hi</sup> vessels, known as type H which play a crucial role in the specialized bone metabolic microenvironment. These vessels are reported to integrate angiogenesis with osteogenesis, thereby influencing angiogenesis-dependent formation. N6-methyladenosine (m6A) modification, mediated by METTL3, is essential eukaryotic mRNA; however, its formation remains unclear. Methods Herein, H-BMECs were screened...
Wen-Shen-Tong-Luo-Zhi-Tong (WSTLZT) Decoction is a Chinese prescription with antiosteoporosis effects, especially in patients abnormal lipid metabolism.To explore the effect and mechanism of WSTLZT on osteoporosis (OP) through adipocyte-derived exosomes.Adipocyte-derived exosomes or without treated were identified by transmission electron microscopy, nanoparticle tracking analysis (NTA) western blotting (WB). Co-culture experiments for bone marrow mesenchymal stem cells (BMSCs) performed to...
We sought to characterize the antibiotic susceptibility of strains Stenotrophomonas maltophilia isolated from clinical samples, and role biofilm in resistance.Fifty-one isolates were obtained patients with nosocomial infection surgical wards ICUs six general hospitals Tianjin, China. In vitro models biofilms established confirmed by scanning electron microscopy fluorescence silver staining. The minimal inhibitory concentrations commonly used antibiotics determined.47 51 resistant three or...
Chinese herbal medicine Fructus Cnidii has an outstanding effect on chronic lumbar pain and impotence, also been used against osteoporosis with high frequency. Yet, the mechanisms of osthole, a derivative Cnidii, osteoclasts remains barely known. In this study, it was found out that osthole (10-6 mol/L, 10-5 mol/L) had influence inhibiting osteoclast formation bone resorptive activities induced by receptor activator nuclear factor κB ligand (RANKL), rather than affecting viability...
Osteoporosis is a chronic inflammatory disease that severely affects quality of life. Cornus officinalis Chinese herbal medicine with various bioactive ingredients, among which morroniside its signature ingredient. Although anti-bone resorption drugs are the main treatment for bone loss, promoting anabolism more suitable increasing mass. Therefore, identifying changes in formation induced by may be conducive to developing effective intervention methods. In this study, was found promote...
Osthole (OST), a derivative of Fructus Cnidii, has been proved to have potential anti-osteoporosis effects in our recent studies. However, its pharmacological are limited the human body because poor solubility and bioavailability. Under guidance classical theory Chinese medicine, Osthole-loaded N-octyl-O-sulfonyl chitosan micelles (NSC-OST), which not previously reported literature, was synthesized order overcome defects obtain better efficacy. In this study, we found that NSC-OST inhibited...
Prostate cancer (PCa) is one of the leading causes death for men worldwide. Unlike some other types cancer, there a lack targeted therapy prostate patients that can kill cells but do much less damage to normal tissue. In this paper, we report on an adenoviral vector enhanced specific transferrin conjugated drug therapy. particular, functional PCa-specific gene probe introduced drive and up-regulate receptor expression PCa via vector. As result, significantly accumulation nanoscale...