A5090536412- Histone Deacetylase Inhibitors Research
- T-cell and Retrovirus Studies
- Ferroptosis and cancer prognosis
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Identification and Quantification in Food
- Renal cell carcinoma treatment
- Renal and related cancers
- Neuroscience of respiration and sleep
- MicroRNA in disease regulation
- Avian ecology and behavior
- Cancer-related molecular mechanisms research
- Adenosine and Purinergic Signaling
- Vagus Nerve Stimulation Research
- Ubiquitin and proteasome pathways
- Mitochondrial Function and Pathology
- Wildlife Ecology and Conservation
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Heart Rate Variability and Autonomic Control
- Calpain Protease Function and Regulation
University of Nottingham Ningbo China
2014-2024
Leshan Normal University
2015-2024
Fudan University Shanghai Cancer Center
2023-2024
South China University of Technology
2024
Shanghai Medical College of Fudan University
2023
Ruijin Hospital
2022-2023
Shanghai Jiao Tong University
2022-2023
Shanghai Institute of Hematology
2022-2023
Shandong University
2020
Liaocheng People's Hospital
2020
Abstract The KEAP1-NRF2 axis is the principal regulator of cellular responses to oxidative and electrophilic stressors. NRF2 hyperactivation frequently observed in many types cancer promotes initiation, progression, metastasis, resistance various therapies. Here, we determined that dipeptidyl peptidase 9 (DPP9) a pathway clear cell renal carcinoma (ccRCC). DPP9 was markedly overexpressed at mRNA protein levels ccRCC, high expression correlated with advanced tumor stage poor prognosis...
Background/Aims: Inflammation plays a vital role in the etiology and pathogenesis of chronic noncommunicable diseases (NCDs), which are leading health issues throughout world. Our previous studies verified satisfactory therapeutic effects Coccomyxa gloeobotrydiformis (CGD) polysaccharide on several NCDs. In this study, we aimed to investigate anti-inflammatory CGD polysaccharide, corresponding molecular mechanisms, lipopolysaccharide (LPS)-induced inflammation RAW264.7 cells. Methods: A...
Aims Osteoarthritis (OA) is a disabling joint disorder and mechanical loading an important pathogenesis. This study aims to investigate the benefits of less created by intermittent tail suspension for knee OA. Methods A post-traumatic OA model was established in 20 rats (12 weeks old, male). Ten were treated with through suspension, while another ten normal loading. Cartilage damage determined gross appearance, Safranin O/Fast Green staining, immunohistochemistry examinations. Subchondral...
Peripheral T-cell lymphoma (PTCL) is a heterogeneous and aggressive disease with poor prognosis. Histone deacetylase (HDAC) inhibitors have shown inhibitory effects on PTCL. A better understanding of the therapeutic mechanism underlying HDAC could help improve treatment strategies. Herein, we found that high expression HDAC3 associated prognosis in inhibition suppressed growth immunocompetent mice but not immunodeficient mice. deletion delayed progression lymphoma, reduced burden thymus,...
After spinal cord injury (SCI), the disruption of blood-spinal barrier by activation endothelin (ET) system is a critical event leading to leukocyte infiltration, inflammatory response and oxidative stress, contributing neurological disability. In present study, we showed that blockade ET receptor A (ETAR) and/or B (ETBR) prevented early responses directly via inhibition neutrophil monocyte diapedesis mediator production following traumatic SCI in mice. Long-term improvement, based on series...
The Russet Bush Warbler Locustella (previously Bradypterus) mandelli complex occurs in mountains the eastern Himalayas, southern China, Vietnam, Philippines, and Indonesia. taxonomy has been debated, with one (L. seebohmi) to four seebohmi, L. mandelli, montis timorensis) species having recognised. We used an integrative approach, incorporating analyses of morphology, vocalizations a molecular marker, re-evaluate limits complex. found that central Chinese differed from those India through...
High glucose (HG) induced podocytes injury plays an important role in diabetes nephropathy (DN) development. Long noncoding RNA cancer susceptibility candidate 2 (CASC2) was found to be decreased serum of DN patients. We aimed explore the function and possible mechanism CASC2 HG injury.Under normal (NG), mannitol stimulated podocyte conditions, levels CASC2, microRNA-9-5p (miR-9-5p) peroxisome proliferator-activated receptor gamma (PPARγ) were examined by quantitative real-time polymerase...
Osteosarcoma (OS) is a common malignant bone cancer threatening children and young adults. Emerging evidence indicates that long non-coding RNAs (lncRNAs) play crucial roles in the progression of OS. Herein, we want to clarify lncRNA human leukocyte antigen complex group 11 (HCG11) Our data revealed HCG11 expression decreased OS, which result transcriptional repression YY1. Low level closely associated with larger tumor size shorter overall survival OS patients. negatively regulates cell...
Summary A number of former forest farms in southern Sichuan province, south-west China have been designated as protected areas following the 1998 logging ban upper Yangtze basin. These are within range endemic Partridge Arborophila rufipectus which has a fragmented distribution remnant broadleaf forests this region, and is currently listed ‘Endangered’ by IUCN. The design robust conservation plan for species hampered lack knowledge about its habitat preferences heavily modified environment....
Abstract Chronic lead exposure causes peripheral sympathetic nerve stimulation, including increased blood pressure and heart rate. Purinergic receptors are involved in the sympathoexcitatory response induced by myocardial ischemia injury. However, whether P2X4 receptor participates chronic possible mechanisms still unknown. The aim of this study was to explore change via stellate ganglion (SG). Rats were given acetate through drinking water freely at doses 0 g/L (control group), 0.5 (low 2...
To investigate the effects of zoledronic acid on muscle metabolism in mice with osteoporosis and sarcopenia elucidate possible underlying mechanism. Twenty-four 8-week-old male C57BL/6J were randomly divided into four groups: non-suspension (N-SUS), suspension (SUS), + (ZA), PTH(PTH) groups. Equal doses saline, acid, PTH administered subcutaneously. After 4 weeks, sacrificed, body weight mass (gastrocnemius soleus) measured, right tibia was taken for micro-CT examination, specimens analyzed...
The Sichuan partridge (Arborophila rufipectus, Phasianidae, Galliformes) is distributed in south-west China, and classified as endangered grade. To examine the evolution genomic features of partridge, we de novo assembled reference genome. final draft assembly consisted approximately 1.09 Gb, had a scaffold N50 4.57 Mb. About 1.94 million heterozygous single-nucleotide polymorphisms (SNPs) were detected, 17,519 protein-coding genes predicted, 9.29% genome was identified repetitive elements....
There are no published studies of the influence geometry scapula on postoperative recovery rotator cuff injuries. Our aim was to explore relationship between critical shoulder angle (CSA), acromion index (AI), glenoid inclination (GI), and repair outcomes in joints after arthroscopic supraspinatus tendon repair.Sixty two patients suffering a tear were analyzed retrospectively following failure conservative treatment subsequent arthroscopy our hospital. Standard anterior posterior X-rays...
Allogeneic stem cell transplantation from haplo-identical donors (haplo-HSCT) has become a well-established therapeutic option for hematological malignancies. The fever of unknown origin (haplo-fever) early after the infusion T repleted graft, which returned to normal right post-transplantation cyclophosphamide (PTCy), is unique clinical feature in patients undergoing haplo-HSCT. In current study, characteristics haplo-fever and cytokine profiles during were retrospectively analyzed cohort...
The direct consequence of metabolic syndrome (MS) is the increased morbidity and mortality caused by heart disease. We tried to explain why more severely damaged during MS from point mitochondria, center cellular metabolism.1. classic diet induced rat model was used observe morphological changes mitochondria transmission electron microscope (TEM); 2. expression mitochondrial DNA (mt-DNA) encoded proteins observed immunohistochemistry Western blot; 3. ribosomal (MRPs) real-time PCR.1. volume...
Abstract Introduction The appropriate and optimal treatment for thoracic lumbar (TL) burst fractures remains a topic of debate. Characterization vertical laminar (coronal cross-sectional imaging) is presented in this study to determine the severity options TL fractures. Methods A retrospective evaluation 341 consecutive patients with was divided into Group I (whole), II (partial), III (intact) based on fracture morphology from coronal images computed tomography (CT) scans. presence...
Summary The critically endangered Sichuan Hill-partridge Arborophila rufipectus occupies a restricted range in south-central China. Field surveys within this were undertaken using line transects 1996 and 1997. Calling males recorded from nine subtropical forest tracts an area totalling 1,793 km 2 consisting of primary, natural secondary replanted broadleaf between 1,100 2,235 m elevation. only sightings obtained primary forest. mean density calling estimated data collected during transect...
The metabolic syndrome (MS) is a cluster of changes that carry high risk cardiovascular disease (CVD). A newly discovered microalga, coccomyxagloeobotrydiformis (CGD), has been reported to improve ischemic stroke and metabolism-related indicators. We observed the therapeutic effects CGD on MS postulated underlying mechanism.A diet-induced model in rats was used observe MS. Blood-glucose lipid indices were measured using enzymatic colorimetric kits. biologic data acquisition analysis system...
AbstractThe complete mitochondrial genome of the fulvous parrotbill (Paradoxornis fulvifrons) has been determined from Illumina sequencing data. The circular is 17 059 bp long, comprising 37 genes (13 protein-coding genes/PCGs, 22 tRNA and two rRNA genes) a putative control region. Except for COX1 with GTG as its start codon, all PCGs are initiated ATR (ATA/ATG) codons. One PCG (COX1) terminated AGG, three (COX3, ND2 ND4) incomplete stop codon T––/TA–, while others TAA. tRNAs range in size...