A5100337014- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Phylogenetic Studies
- Genomics and Chromatin Dynamics
- Wheat and Barley Genetics and Pathology
- Primate Behavior and Ecology
- Genetic diversity and population structure
- Genetics and Plant Breeding
- RNA modifications and cancer
- Chromosomal and Genetic Variations
- Genetic and phenotypic traits in livestock
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Plant biochemistry and biosynthesis
- Plant Gene Expression Analysis
- Plant Molecular Biology Research
- Amphibian and Reptile Biology
- Insect and Arachnid Ecology and Behavior
- Fibroblast Growth Factor Research
- Plant and animal studies
- Animal Behavior and Reproduction
- Epigenetics and DNA Methylation
- Building materials and conservation
- Kruppel-like factors research
- Crop Yield and Soil Fertility
- Image Processing and 3D Reconstruction
Sichuan Agricultural University
2016-2025
Chongqing University
2023-2025
Chongqing Academy of Agricultural Sciences
2024-2025
Changzhou Vocational Institute of Textile and Garment
2025
Shandong University
2025
Sichuan University
2014-2024
Zhengzhou University
2024
Ministry of Agriculture and Rural Affairs
2022-2024
Anhui University of Traditional Chinese Medicine
2023-2024
Kunming University
2023-2024
N6-methyladenosine (m6A) is the most abundant epigenetic modification in eukaryotic mRNAs and essential for multiple RNA processing events during mammalian development disease control. Here we show that conditional knockout of m6A methyltransferase Mettl3 bone marrow mesenchymal stem cells (MSCs) induces pathological features osteoporosis mice. loss-of-function results impaired formation, incompetent osteogenic differentiation potential increased adiposity. Moreover, overexpression MSCs...
The bHLH (basic helix–loop–helix) transcription factors function as crucial regulators in numerous biological processes including abiotic stress responses and plant development. According to our RNA-seq analysis of tomato seedlings under salt stress, we found that, although the gene family has been studied, there are still so many genes that have not identified named, which will hinder later study SlbHLHs. In total, 195 SlbHLHs were unevenly distributed onto 12 chromosomes from genome...
The Tibetan grey wolf (Canis lupus chanco) occupies habitats on the Qinghai-Tibet Plateau, a high altitude (>3000 m) environment where low oxygen tension exerts unique selection pressure individuals to adapt hypoxic conditions. To identify genes involved in hypoxia adaptation, we generated complete genome sequences of nine Chinese wolves from and populations at an average coverage 25× coverage. We found that, beginning about 55,000 years ago, highland suffered more substantial population...
Noncoding transcription is a defining feature of active enhancers, linking factor (TF) binding to the molecular mechanisms controlling gene expression. To determine relationship between enhancer activity and biological outcomes in breast cancers, we profiled transcriptomes (using GRO-seq RNA-seq) epigenomes ChIP-seq) 11 different human cancer cell lines representing five major subtypes cancer, as well two immortalized (“normal”) lines. In addition, developed robust unbiased computational...
SUMMARY Acer truncatum (purpleblow maple) is a woody tree species that produces seeds with high levels of valuable fatty acids (especially nervonic acid). However, the lack complete genome sequence has limited both basic and applied research on A. . We describe high‐quality draft assembly comprising 633.28 Mb (contig N50 = 773.17 kb; scaffold 46.36 Mb) at least 28 438 predicted genes. The underwent an ancient triplication, similar to core eudicots, but there have been no recent whole‐genome...
Abstract Folliculogenesis is a complex biological process involving central oocyte and its surrounding somatic cells. Three-dimensional chromatin architecture an important transcription regulator; however, little known about dynamics role in transcriptional regulation of granulosa cells during chicken folliculogenesis. We investigate the transcriptomic over ten follicular stages assess how it influences gene expression at three key stages: prehierarchical small white follicles, first largest...
Abstract The quantification of animal social behaviour is an essential step to reveal brain functions and psychiatric disorders during interaction phases. While deep learning-based approaches have enabled precise pose estimation, identification behavioural classification multi-animals, their application challenged by the lack well-annotated datasets. Here we show a computational framework, Social Behavior Atlas (SBeA) used overcome problem caused limited SBeA uses much smaller number...
In plants, hexokinase (HXK) is a kind of bifunctional enzyme involved in sugar metabolism and signal transduction that plays important roles plant growth development stress response. Some HXK genes without phosphorylation function have been found Arabidopsis, tobacco, etc., but these not identified tomato. Therefore, further genome-wide systematic identification characterization necessary for tomato genes. this study, six were from the genome distributed across different chromosomes, named...
Abstract Background Species living at high altitude are subject to strong selective pressures due inhospitable environments (e.g., hypoxia, low temperature, solar radiation, and lack of biological production), making these species valuable models for comparative analyses local adaptation. Studies that have examined high-altitude adaptation identified a vast array rapidly evolving genes characterize the dramatic phenotypic changes in animals. However, how environment shapes gene expression...
Stripe rust is a serious fungal disease of wheat (Triticum aestivum L.) caused by Puccinia striiformis f. sp. tritici (Pst), which results in yield reduction and decreased grain quality. Breeding for genetic resistance to stripe the most cost-effective method control disease. In present study, genome-wide association study (GWAS) was conducted identify markers linked genes (or loci) 93 Northern Chinese landraces, using Diversity Arrays Technology (DArT) simple sequence repeat (SSR) molecular...
Avian ovaries develop asymmetrically apart from prey birds, with only the left ovary growing more towards functional organ. Here, we analyze over 135,000 cells chick's and right at six distinct embryonic developmental stages utilizing single-cell transcriptome sequencing. We delineate gene expression patterns across 15 cell types within these embryo ovaries, revealing side-specific development. The exhibit cortex cells, zygotene germ transcriptional changes unique to side. Differential...
The ammonia monooxygenase (AMO)/particulate methane (pMMO) superfamily is a diverse group of membrane-bound enzymes which only pMMO has been characterized on the molecular level. active site believed to reside in soluble N-terminal region pmoB subunit. To understand degree structural conservation within this superfamily, crystal structure corresponding domain an archaeal amoB subunit from Nitrosocaldus yellowstonii determined 1.8 Å resolution. reveals remarkable overall fold and copper...
The interaction of melanocortin-4 (MC4R) and melanocortin-3 (MC3R) receptors with proopiomelanocortin (POMC)-derived peptides (e.g. α-MSH), agouti-related protein (AgRP) melanocortin-2 receptor accessory 2 (MRAP2) is suggested to play critical roles in energy balance vertebrates. However, evidence on their birds remains scarce. Our study aims reveal chickens the results showed that (1) chicken (c-)MC3R cMC4R expressed Chinese hamster ovary (CHO) cells can be activated by α-MSH ACTH1-39...
Stripe rust (also called yellow rust) is a common and serious fungal disease of wheat (Triticum aestivum L.) caused by Puccinia striiformis f. sp. tritici. The narrow genetic basis modern cultivars rapid evolution the pathogen have been responsible for periodic devastating epidemics diseases. In this study, we conducted genome-wide association study with 44,059 single nucleotide polymorphism markers to identify loci associated resistance stripe in 244 Sichuan accessions, including 79...
Macaques are the most widely distributed nonhuman primates and used as animal models in biomedical research. The availability of full-genome sequences from them would be essential to both primate evolutionary studies. Previous studies have reported whole-genome rhesus macaque (Macaca mulatta) cynomolgus (M. fascicularis, CE), which belong fascicularis group. Here, we present a 37-fold coverage genome sequence Tibetan thibetana; TM). TM is an endemic species China belonging sinica On basis...
Stripe rust (also known as yellow rust), caused by the pathogen Puccinia striiformis f. sp. Tritici (Pst), is a common and serious fungal disease of wheat (Triticum aestivum L.) worldwide. To identify effective stripe resistance loci, genome-wide association study was performed using 152 landraces from Yellow Huai River Valleys in China, with Diversity Arrays Technology simple sequence repeat markers. Phenotypic evaluations levels to at adult-plant stage under field conditions were carried...
Abstract Coptis chinensis Franch, a perennial herb, is mainly distributed in southeastern China. The rhizome of C. has been used as traditional medicine for more than 2000 years China and many other Asian countries. pharmacological activities have validated by research. Here, we present de novo high-quality genome with chromosome-level ~958.20 Mb, contig N50 1.58 scaffold 4.53 Mb. We found that the relatively large size was caused amplification long terminal repeat (LTR) retrotransposons. In...
Abstract Haplotype‐resolved 3D chromatin architecture related to allelic differences in avian skeletal muscle development has not been addressed so far, although chicken husbandry for meat consumption prevalent feature of cultures on every continent more than thousands years. Here, high‐resolution Hi‐C diploid maps (1.2‐kb maximum resolution) are generated tissues across three developmental stages (embryonic day 15 30 post‐hatching). The sequence features governing spatial arrangement...
To comprehend the current state of death anxiety among Chinese college students during COVID-19 pandemic, analyze its influencing factors, and provide recommendations for mitigating these students. From March to May 2023, utilizing a cluster sampling method, from three universities in Changzhou, Jiangsu, were selected as research participants. The investigation employed general information questionnaire, PTSD Checklist DSM-5 (PCL-5), Version Templer-Death Anxiety Scale (CT-DAS), brief...
Abstract Background Antimicrobial toxin genes (ATGs) encode potent antimicrobial weapons in nature that rival antibiotics, significantly impacting microbial survival and offering potential benefits for human health. However, the drivers of their global diversity biogeography remain unknown. Results Here, we identified 4400 ATG clusters from 149 families by correlating 10,000 samples worldwide with over 200,000 genome data. We demonstrated communities universally complex diverse ATGs,...
Neonatal mammals must rapidly adapt to significant physiological changes during the transition from intrauterine extrauterine environments. This adaptation, particularly in metabolic and respiratory systems, is essential for survival. MicroRNAs (miRNAs) are small noncoding RNAs that regulate various pathological processes by binding 3′ untranslated regions of mRNAs. study aimed identify miRNAs involved early adaptation neonatal piglets explore their functions. We performed RNA sequencing on...
BACKGROUND Secondary malignancies of salivary glands (SMSGs) are among the most common malignant neoplasms to involve glands. Fine‐needle aspiration biopsy (FNAB) SMSG can present diagnostic challenges. The current report presents largest such FNAB series date. METHODS A search pathology database from 6 academic institutions identified 184 cases nonlymphomatous SMSG. RESULTS Of cases, 171 were parotid glands, and 13 submandibular glands; 130 patients men, 54 women, mean patient age at...