A5036364465- Adipose Tissue and Metabolism
- Genomics and Phylogenetic Studies
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Peroxisome Proliferator-Activated Receptors
- Plant biochemistry and biosynthesis
- Plant Virus Research Studies
- Plant Pathogens and Fungal Diseases
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Plant and animal studies
- Invertebrate Immune Response Mechanisms
- Hippo pathway signaling and YAP/TAZ
- Genetic diversity and population structure
- Adipokines, Inflammation, and Metabolic Diseases
- Fungal Biology and Applications
- Ginger and Zingiberaceae research
- Animal Nutrition and Physiology
- Diet and metabolism studies
- Mycorrhizal Fungi and Plant Interactions
- Plant Disease Resistance and Genetics
- RNA Research and Splicing
- Antimicrobial Peptides and Activities
- Lipid metabolism and biosynthesis
- Plant-Microbe Interactions and Immunity
Ningbo University
2024-2025
University of Massachusetts Chan Medical School
2015-2025
Ministry of Agriculture and Rural Affairs
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Hubei University of Chinese Medicine
2022-2024
Shandong University
2024
Henan University of Science and Technology
2024
Novogene Bioinformatics Institute
2021-2024
Shanghai Chest Hospital
2024
Shanghai Jiao Tong University
2024
The inducible expression of antimicrobial peptide genes in Drosophila melanogaster is regulated by the conserved Toll and peptidoglycan recognition protein LC/immune deficiency (PGRP-LC/IMD) signaling pathways. It has been proposed that two pathways have independent functions mediate specificity innate immune responses towards different microorganisms. Scattered evidence also suggests some target can be activated both IMD, albeit to extents. This dual activation mediated stimulation or...
Accumulating evidence suggests that the insect and mammalian innate immune response is mediated by homologous regulatory components.Proinflammatory cytokines bacterial lipopolysaccharide stimulate immunity activating transcription factors such as NF-B AP-1.One of responses evoked these stimuli initiation a kinase cascade leads to phosphorylation p38 mitogen-activated protein (MAP) on Thr Tyr within motif Thr-Gly-Tyr, which located subdomain VIII.We have investigated possible involvement MAP...
Insulin resistance is a major characteristic of obesity and type 2 diabetes, but the underlying mechanism unclear. Recent studies have shown metabolic role capsaicin that may be mediated via transient receptor potential vanilloid type-1 (TRPV1) channel. In this study, TRPV1 knockout (KO) wild-type (WT) mice (as controls) were fed high-fat diet (HFD), performed to measure insulin leptin action. The KO became more obese than WT after HFD, partly attributed altered energy balance in mice....
Altered energy balance and insulin resistance are important characteristics of aging. Skeletal muscle is a major site glucose disposal, the role aging-associated inflammation in skeletal remains unclear. To investigate, we examined metabolism 18-mo-old transgenic mice with muscle-specific overexpression IL-10 (MIL10) wild-type during hyperinsulinemic-euglycemic clamping. Despite similar fat mass balance, MIL10 were protected from significant increases infusion rates, whole-body turnover,...
Abstract Pitaya ( Hylocereus ) is the most economically important fleshy-fruited tree of Cactaceae family that grown worldwide, and it has attracted significant attention because its betalain-abundant fruits. Nonetheless, lack a pitaya reference genome significantly hinders studies focused on evolution, as well potential for genetic improvement this crop. Herein, we employed various sequencing approaches, namely, PacBio-SMRT, Illumina HiSeq paired-end, 10× Genomics, Hi-C (high-throughput...
Abstract Obesity and type 2 diabetes are associated with disturbances in insulin-regulated glucose lipid fluxes severe comorbidities including cardiovascular disease steatohepatitis. Whole body metabolism is regulated by lipid-storing white adipocytes as well “brown” “brite/beige” that express thermogenic uncoupling protein 1 (UCP1) secrete factors favorable to metabolic health. Implantation of brown fat into obese mice improves tolerance, but translation humans has been stymied low...
Abstract The Allium genus is cultivated globally as vegetables, condiments, or medicinal plants and characterized by large genomes strong pungency. However, the genome evolution genomic basis underlying their unique flavor formation remain poorly understood. Herein, we report an 11.27-Gb chromosome-scale assembly for bunching onion ( A. fistulosum ). uneven bursts of long-terminal repeats contribute to diversity in constituents, dispersed duplication events largely account gene expansion...
Initiation of development requires differential gene expression and metabolic adaptations. Here we show in the nematode-trapping fungus, Arthrobotrys flagrans, that both are achieved through a dual-function G-protein-coupled receptor (GPCR). A. flagrans develops adhesive traps recognizes its prey, Caenorhabditis elegans, nematode-specific pheromones (ascarosides). Gene-expression analyses revealed ascarosides activate fungal GPCR, GprC, at plasma membrane together with G-protein alpha...
The Toll family of receptors is required for innate immune response to pathogen-associated molecules, but the mechanism signaling not entirely clear. In Drosophila prototypic regulates both embryonic development and adult response. We demonstrate here that host protein Spätzle can function as a ligand because forms complex with in transgenic fly extracts stimulates expression Toll-dependent immunity gene, drosomycin , flies. also show constitutively active mutants form multimers contain...
Salicylic acid is a phenolic phytohormone which controls plant growth and development. A methyl ester (MSA) derivative thereof volatile involved in plant-insect or plant-plant communication. Here we show that the nematode-trapping fungus Duddingtonia flagrans uses methyl-salicylic isomer, 6-MSA as morphogen for spatiotemporal control of trap formation chemoattractant to lure Caenorhabditis elegans into fungal colonies. product polyketide synthase an intermediate biosynthesis arthrosporols....
Abstract Opium poppy ( Papaver somniferum ) is a source of morphine, codeine, and semisynthetic derivatives, including oxycodone naltrexone. Here, we report the de novo assembly genomic analysis P. traditional landrace ‘Chinese Herbal Medicine’. Variations between 2.62 Gb CHM genome that previously sequenced high noscapine 1 (HN1) variety were also explored. Among 79,668 protein-coding genes, functionally annotated 88.9%, compared to 68.8% reported in HN1 genome. Gene family 4DTv comparative...
Aims The aim of this study was to investigate the effects chlorogenic acid (CGA) on intestinal microorganisms and metabolites in broilers during lipopolysaccharide (LPS)-induced immune stress. Methods A total 312 one-day-old Arbor Acres (AA) were randomly allocated four groups with six replicates per group 13 replicate: (1) MS (injected saline fed basal diet); (2) ML 0.5 mg LPS/kg (3) MA diet supplemented 1,000 mg/kg CGA); (4) MB CGA). Results results showed that abundance beneficial...
Abstract Obesity is a major cause of metabolic dysfunction-associated steatohepatitis (MASH) and characterized by inflammation insulin resistance. Interferon-γ (IFNγ) pro-inflammatory cytokine elevated in obesity modulating macrophage functions. Here, we show that male mice with loss IFNγ signaling myeloid cells (Lyz-IFNγR2 −/− ) are protected from diet-induced resistance despite fatty liver. Obesity-mediated liver also attenuated reduced interleukin (IL)−12, primarily released macrophages,...
Abstract As part of a genome sequencing project for Ophiocordyceps sinensis , strain 1229, complete mitochondrial (mt) was assembled as single circular dsDNA 157,510 bp, one the largest reported fungi. Conserved genes including large and small rRNA subunits, 27 tRNA 15 protein-coding genes, were identified. In addition, 58 non-conserved open reading frames (ncORFs) in intergenic intronic regions also Transcription analyses using RNA-Seq validated expression most conserved ncORFs. Fifty-two...
Abstract Coptis chinensis Franch, a perennial herb, is mainly distributed in southeastern China. The rhizome of C. has been used as traditional medicine for more than 2000 years China and many other Asian countries. pharmacological activities have validated by research. Here, we present de novo high-quality genome with chromosome-level ~958.20 Mb, contig N50 1.58 scaffold 4.53 Mb. We found that the relatively large size was caused amplification long terminal repeat (LTR) retrotransposons. In...
Southwest China is a plant diversity hotspot. The near-cosmopolitan genus Ilex (c. 664 spp., Aquifoliaceae) reaches its maximum in this region, with many narrow-range and few widespread species. Divergent selection on species leads to local adaptation, consequences for both conservation utilization, but counteracted by geneflow. Many are utilized as teas, medicines, ornamentals, honey plants, timber, variation below the level largely uninvestigated. We therefore studied polyneura, which...
CCCTC-binding factor (CTCF), a ubiquitously expressed architectural protein, has emerged as key regulator of cell identity gene transcription. However, the precise molecular mechanism underlying specialized functions CTCF remains elusive. Here, we investigate through integrative analyses primary hepatocytes, myocytes, and B cells from mouse human. We demonstrate that cooperates with lineage-specific pioneer transcription factors (TFs), including MyoD, FOXA, PU.1, to control at 1D 3D levels....
Dipterocarpoideae species form the emergent layer of Asian rainforests. They are indicator for rainforest distribution, but they severely threatened. Here, to understand their adaptation and population decline, we assemble high-quality genomes seven including two autotetraploid species. We estimate divergence time between Malvaceae within be 108.2 (97.8‒118.2) 88.4 (77.7‒102.9) million years ago, identify a whole genome duplication event preceding dipterocarp lineage diversification. find...
This study was designed to examine the impact of aspirin eugenol ester (AEE) on growth performance, serum antioxidant capacity, jejunal barrier function, and cecal microbiota broilers raised under stressful high density (HD) stocking conditions compared with normal (ND). A total 432 one-day-old AA+ male were randomly divided into 4 groups: (ND, 14 /m