A5100445164- Berberine and alkaloids research
- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Cholinesterase and Neurodegenerative Diseases
- Cannabis and Cannabinoid Research
- Marine Sponges and Natural Products
- Carbohydrate Chemistry and Synthesis
- Treatment of Major Depression
- Diet, Metabolism, and Disease
- Alzheimer's disease research and treatments
- Natural product bioactivities and synthesis
- Electrochemical sensors and biosensors
- Molecular Sensors and Ion Detection
- Alkaloids: synthesis and pharmacology
- Flavonoids in Medical Research
- Chemical synthesis and alkaloids
- Genetic diversity and population structure
- Chemical Synthesis and Analysis
- Synthesis of Organic Compounds
- Mycorrhizal Fungi and Plant Interactions
- MicroRNA in disease regulation
- Functional Brain Connectivity Studies
- Phytochemistry and Biological Activities
- Biological Activity of Diterpenoids and Biflavonoids
- Seaweed-derived Bioactive Compounds
Sichuan University
2023-2024
West China Hospital of Sichuan University
2023-2024
Tianjin University of Traditional Chinese Medicine
2019-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2024
Chongqing Academy of Chinese Materia Medica
2021-2024
Hangzhou Hospital of Traditional Chinese Medicine
2024
China Academy of Chinese Medical Sciences
2021-2024
Tianjin haihe hospital
2024
First Affiliated Hospital of Zhengzhou University
2022-2023
Background/Aims: Acute lung injury (ALI) is induced by a variety of external and internal factors leads to acute progressive respiratory failure. Previous studies have shown that apelin-13 can decrease the LPS, but specific mechanism unclear. Therefore, mouse model cell were designed explore how alleviates caused LPS. Methods: The effect on LPS-induced structural damage was determined H&E staining wet/dry weight ratio. related inflammatory in BALF examined ELISA. apoptotic pathway NF-κB...
Abstract Menispermaceae species, as early‐diverging eudicots, can synthesize valuable benzylisoquinoline alkaloids (BIAs) like bisbenzylisoquinoline (bisBIAs) and sinomenines with a wide range of structural diversity. However, the evolutionary mechanisms responsible for their chemo‐diversity are not well understood. Here, chromosome‐level genome assembly Menispermum dauricum is presented demonstrated occurrence two whole duplication (WGD) events that shared by Ranunculales specific to ,...
The benzylisoquinoline alkaloids (BIAs) are an important group of secondary metabolites from higher plants and have been reported to show significant biological activities. production BIAs through synthetic biology approaches provides a higher-yielding strategy than traditional methods or isolation plant material. However, the reconstruction BIA pathways in microorganisms by combining heterologous enzymes can also give access cascade reactions. Most importantly, non-natural be generated such...
Atherosclerosis is a multifactorial vascular disease triggered by disordered lipid metabolism, characterized chronic inflammatory injury, and initiated endothelial dysfunction. Berberine the main active alkaloid of herbal medicine Coptidis Rhizoma (Huanglian). Notably, berberine has been shown to have beneficial effects against atherosclerosis. However, mechanisms in preventing atherosclerosis are still unclear. This study aimed at investigating protecting aorta ameliorating apolipoprotein...
Abstract Coptis chinensis Franch, a perennial herb, is mainly distributed in southeastern China. The rhizome of C. has been used as traditional medicine for more than 2000 years China and many other Asian countries. pharmacological activities have validated by research. Here, we present de novo high-quality genome with chromosome-level ~958.20 Mb, contig N50 1.58 scaffold 4.53 Mb. We found that the relatively large size was caused amplification long terminal repeat (LTR) retrotransposons. In...
Corydalis yanhusuo W.T. Wang is a traditional herb. Benzylisoquinoline alkaloids (BIAs) are the main pharmacological active ingredients that play an important role in sedation, relieving pain, promoting blood circulation, and inhibiting cancer cells. However, there few studies on biosynthetic pathway of benzylisoquinoline , especially some specific components, such as tetrahydropalmatine. We carried out widely targeted metabolome transcriptomic analyses to construct identified candidate...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThree New Triterpenoids from Antrodia cinnamomeaI-Hwa Cherng, Hung-Cheh Chiang, Ming-Chu Cheng, and Yu WangCite this: J. Nat. Prod. 1995, 58, 3, 365–371Publication Date (Print):March 1, 1995Publication History Published online1 July 2004Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/np50117a004https://doi.org/10.1021/np50117a004research-articleACS PublicationsRequest reuse permissionsArticle Views739Altmetric-Citations76LEARN ABOUT...
Abstract Five new diketopiperazines, prenylcyclotryprostatin B ( 1 ), 20‐hydroxycyclotryprostatin 2 9‐hydroxyfumitremorgin C 3 6‐hydroxytryprostatin 4 and spirogliotoxin 5 were isolated from the marine‐derived fungus Aspergillus fumigatus YK‐7, along with nine known compounds, 6 – 14 . Their structures elucidated by spectroscopic methods, their antiproliferative effects on human leukemic monocyte lymphoma U937 prostate cancer PC‐3 cell lines assessed in vitro. Compounds 10, 12 , 13 exhibited...
Abstract Background Few studies have focused on functional impairment in depressed patients during symptomatic remission. The exact relationship between cognitive performance and outcomes of with Major depressive disorder (MDD) remains unclear. Methods Participants diagnosed MDD were included interviewed at both baseline follow-up. Cognitive function was assessed acute episodes using the Cambridge Neuropsychological Test Automated Battery (CANTAB), which targeted attention (Rapid Visual...
Extracellular enzymes play an important role in the growth and development of edible fungi. enzyme activities have also become object measurement. In this study, Agaricus brunnescens Peck, Coprinus comatus, Pleurotus ostreatus were compared terms their production liquid-and solid-state fermentation. Differences ability various types fungi to utilize biomass raw materials analyzed by monitoring fiber degradation rate during crop straw degradation, changes cellulolytic systems metabolism...
In the present study, we investigated mechanisms of chamaejasmine action on human HEp-2 larynx carcinoma cells, which possess constitutively active Akt. Results indicated that showed more notable anticancer activity than apigenin against HEp-2, PC-3, NCI-H1975, HT-29 and SKOV-3. Moreover, presented most significantly inhibition towards with IC₅₀ values 1.92 µM. Treatment cells (1-4 μM) resulted in significant dose-dependent decrease Akt phosphorylation at Serine473. Chamaejasmine-mediated...
<b><i>Aim:</i></b> This study was designed to develop sanguinarine-loaded solid lipid nanoparticles (SG-SLNs) and investigate its gastroprotective effect on ethanol-induced gastric mucosal lesions in mice. <b><i>Methods:</i></b> SG-SLNs were prepared by high temperature melt-cool solidification method using glycerol monostearate as the a combination of lecithin with poloxamer 188 surfactants. Solid (SLNs) at varying concentrations (5, 10, 15,...
A new neoclerodane-type diterpenoid lactone, scutellone E, together with a known compound, D (scuterivulactone D), has been isolated from aerial parts of Scutellaria rivularis WALL. Their structures have determined X-ray diffraction, spectral and chemical evidence.
Calcium channel blockers are used as neuroprotective agents, glutamate antagonists. However, it has been found that calcium may compromise neuronal survival after long-term exposure. To explore the mechanisms of toxicity on neurons, we studied morphological characteristics and biochemical changes cultured cortical neurons treated with verapamil, a blocker. We now report cerebral cultures exposed to verapamil for 48 h undergo degeneration in both concentration-dependent time-dependent...