Chengzhi Liang
A5004188121- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Plant Genetic and Mutation Studies
- Plant Disease Resistance and Genetics
- Wheat and Barley Genetics and Pathology
- Plant Molecular Biology Research
- Plant Reproductive Biology
- Genetic diversity and population structure
- Rice Cultivation and Yield Improvement
- RNA and protein synthesis mechanisms
- Genetic and phenotypic traits in livestock
- Plant biochemistry and biosynthesis
- Plant-Microbe Interactions and Immunity
- GABA and Rice Research
- Photosynthetic Processes and Mechanisms
- Hip and Femur Fractures
- Bioinformatics and Genomic Networks
- CRISPR and Genetic Engineering
- Algal biology and biofuel production
- Legume Nitrogen Fixing Symbiosis
- Pelvic and Acetabular Injuries
- Cancer-related molecular mechanisms research
- Plant Virus Research Studies
- Plant and animal studies
Chinese Academy of Sciences
2016-2025
Institute of Genetics and Developmental Biology
2016-2025
Nanchang University
2023-2025
State Key Laboratory of Plant Genomics
2016-2025
Second Affiliated Hospital of Nanchang University
2023-2025
University of Chinese Academy of Sciences
2017-2024
Hebei University
2022-2024
Chongqing University of Posts and Telecommunications
2024
Qingdao University
2021-2023
Affiliated Hospital of Qingdao University
2021-2023
A-Maize-ing Maize is one of our oldest and most important crops, having been domesticated approximately 9000 years ago in central Mexico. Schnable et al. (p. 1112 ; see the cover) present results sequencing B73 inbred maize line. The findings elucidate how became diploid after an ancestral doubling its chromosomes reveals transposable element movement activity recombination. Vielle-Calzada 1078 ) have sequenced Palomero Toluqueño ( landrace, a highland popcorn from Mexico, which, when...
Abstract A number of different approaches have been described to identify proteins from tandem mass spectrometry (MS/MS) data. The most common rely on the available databases match experimental MS/MS These methods suffer several drawbacks and cannot be used for identification unknown genomes. In this communication, we describe a new de novo sequencing software package, PEAKS, extract amino acid sequence information without use databases. PEAKS uses model algorithm efficiently compute best...
Cytosine and adenine base editors (CBEs ABEs) are promising new tools for achieving the precise genetic changes required disease treatment trait improvement. However, genome-wide unbiased analyses of their off-target effects in vivo still lacking. Our whole-genome sequencing analysis rice plants treated with third-generation editor (BE3), high-fidelity BE3 (HF1-BE3), or ABE revealed that HF1-BE3, but not ABE, induce substantial mutations, which mostly C→T type single-nucleotide variants...
Triticum urartu (diploid, AA) is the progenitor of A subgenome tetraploid (Triticum turgidum, AABB) and hexaploid aestivum, AABBDD) wheat1,2. Genomic studies T. have been useful for investigating structure, function evolution polyploid wheat genomes. Here we report generation a high-quality genome sequence by combining bacterial artificial chromosome (BAC)-by-BAC sequencing, single molecule real-time whole-genome shotgun sequencing3, linked reads optical mapping4,5. We assembled seven...
Abstract Maize is an important crop with a high level of genome diversity and heterosis. The sequence typical female line, B73, was previously released. Here, we report de novo assembly corresponding male representative Mo17. More than 96.4% the 2,183 Mb assembled can be accounted for by 362 scaffolds in ten pseudochromosomes 38,620 annotated protein-coding genes. Comparative analysis revealed large gene-order gene structural variations: approximately 10% genes were mutually nonsyntenic,...
Tartary buckwheat (Fagopyrum tataricum) is an important pseudocereal crop that strongly adapted to growth in adverse environments. Its gluten-free grain contains complete proteins with a well-balanced composition of essential amino acids and rich source beneficial phytochemicals provide significant health benefits. Here, we report high-quality, chromosome-scale genome sequence 489.3 Mb assembled by combining whole-genome shotgun sequencing both Illumina short reads single-molecule real-time...
Abstract A high-quality reference genome is critical for understanding structure, genetic variation and evolution of an organism. Here we report the de novo assembly indica rice Shuhui498 (R498) through integration single-molecule sequencing mapping data, map fosmid sequence tags. The 390.3 Mb estimated to cover more than 99% R498 continuous current genomes japonica Nipponbare (MSU7) Arabidopsis thaliana (TAIR10). We annotate protein-coding genes in identify variations between...
Plant roots encounter numerous pathogenic microbes that often cause devastating diseases. One such pathogen, Plasmodiophora brassicae (Pb), causes clubroot disease and severe yield losses on cruciferous crops worldwide. Here, we report the isolation characterization of WeiTsing (WTS), a broad-spectrum resistance gene from Arabidopsis. WTS is transcriptionally activated in pericycle upon Pb infection to prevent pathogen colonization stele. Brassica napus carrying transgene displayed strong...
The wild species of the genus Oryza contain a largely untapped reservoir agronomically important genes for rice improvement. Here we report 261-Mb de novo assembled genome sequence brachyantha. Low activity long-terminal repeat retrotransposons and massive internal deletions ancient elements lead to compact We model 32,038 protein-coding in brachyantha genome, which only 70% are located collinear positions comparison with genome. Analysing breakpoints non-collinear suggests that...
It has been suggested that melatonin acts as an important regulator in controlling root growth and development, but the underlying molecular mechanism driving this relationship remains undetermined. In study, we demonstrated a potent molecule to govern architecture rice. Treatments with significantly inhibited embryonic growth, promoted lateral formation development. Genome-wide expression profiling by RNA-sequencing revealed auxin-related genes were activated under treatment. Moreover,...
Hybrid rice is the dominant form of planted in China, and its use has extended worldwide since 1970s. It offers great yield advantages contributed greatly to world's food security. However, molecular mechanisms underlying heterosis have remained a mystery. In this study we integrated genetics omics analyses determine candidate genes for model two-line hybrid system, Liang-you-pei 9 (LYP9) parents. Phenomics revealed that better parent (BPH) not ascribed BPH all components but specific...
Abstract Snapdragon ( Antirrhinum majus L.), a member of the Plantaginaceae family, is an important model for plant genetics and molecular studies on growth development, transposon biology self-incompatibility. Here we report near-complete genome assembly A. cultivar JI7 cv.JI7) comprising 510 Megabases (Mb) genomic sequence containing 37,714 annotated protein-coding genes. Scaffolds covering 97.12% assembled were anchored eight chromosomes. Comparative evolutionary analyses revealed that...
Abstract The abundant repetitive sequences in complex eukaryotic genomes cause fragmented assemblies, which lose value as reference genomes, often due to incomplete gene and unanchored or mispositioned contigs on chromosomes. Here we report a genome assembly method HERA, resolves repeats efficiently by constructing connection graph from an overlap graph. We test HERA the of rice, maize, human, Tartary buckwheat with single-molecule sequencing mapping data. correctly assembles most previously...
Abstract Understanding the genetic basis of rubber tree ( Hevea brasiliensis ) domestication is crucial for further improving natural production to meet its increasing demand worldwide. Here we provide a high-quality H. genome assembly (1.58 Gb, contig N50 11.21 megabases), present map variations by resequencing 335 accessions and reveal domestication-related molecular signals major trait, higher number laticifer rings. We show that HbPSK5 , encoding small-peptide hormone phytosulfokine...
Common buckwheat (Fagopyrum esculentum) and Tartary tataricum), the two most widely cultivated species, differ greatly in flavonoid content reproductive mode. Here, we report first high-quality chromosome-level genome assembly of common with 1.2 Gb. Comparative genomic analysis revealed that underwent a burst long terminal repeat retrotransposons insertion accompanied by numerous large chromosome rearrangements after divergence from buckwheat. Moreover, multiple gene families involved stress...
The National Genomics Data Center (NGDC), which is a part of the China for Bioinformation (CNCB), offers comprehensive suite database resources to support global scientific community. Amidst unprecedented accumulation multi-omics data, CNCB-NGDC committed continually evolving and updating its core through big data archiving, integrative analysis value-added curation. Over past year, has expanded collaborations with international databases established new subcenters focusing on biodiversity,...