A5101570129- Liver Disease Diagnosis and Treatment
- Reproductive Physiology in Livestock
- Inflammasome and immune disorders
- Reproductive System and Pregnancy
- Cardiovascular Disease and Adiposity
- Heavy Metal Exposure and Toxicity
- Platelet Disorders and Treatments
- Gout, Hyperuricemia, Uric Acid
- Immunotherapy and Immune Responses
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Selenium in Biological Systems
- Nephrotoxicity and Medicinal Plants
- Adrenal and Paraganglionic Tumors
- Chronic Lymphocytic Leukemia Research
- Prostate Cancer Treatment and Research
- Muscle Physiology and Disorders
- Eicosanoids and Hypertension Pharmacology
- Genomics, phytochemicals, and oxidative stress
- Systemic Lupus Erythematosus Research
- Hormonal Regulation and Hypertension
- Alcohol Consumption and Health Effects
- Mesenchymal stem cell research
- Vasculitis and related conditions
- Urinary Bladder and Prostate Research
- Adipose Tissue and Metabolism
Capital Medical University
2025
Northeast Agricultural University
2021-2025
University of Pennsylvania
2021-2025
Beijing Tongren Hospital
2025
First Affiliated Hospital of Anhui Medical University
2023-2024
Anhui Medical University
2021-2024
Shanghai University of Traditional Chinese Medicine
2024
Chongqing Medical University
2015-2024
Shuguang Hospital
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2020-2024
ABSTRACT The prevalence of arterial stiffness and hypertension increases with age. This study investigates the effect induced pluripotent mesenchymal stem cell‐derived extracellular vesicles (EVs) on ageing‐associated hypertension. EVs were collected purified from cells (iPS‐MSCs). Young old male C57BL/6 mice used. Mice in group injected via tail vein once a week for four weeks (18 x 10 6 EVs/mouse/injection). Blood pressure (BP) was measured using tail‐cuff method validated by direct...
Common buckwheat (Fagopyrum esculentum) and Tartary tataricum), the two most widely cultivated species, differ greatly in flavonoid content reproductive mode. Here, we report first high-quality chromosome-level genome assembly of common with 1.2 Gb. Comparative genomic analysis revealed that underwent a burst long terminal repeat retrotransposons insertion accompanied by numerous large chromosome rearrangements after divergence from buckwheat. Moreover, multiple gene families involved stress...
Cadmium (Cd) is a highly toxic metal pollutant that can endanger the life and health of animals. Toll-like receptor 4 (TLR4) result in testicular cell damage by positively regulating mitogen-activated protein kinase (MAPK)/nuclear factor-kappaB (NF-κB) signaling pathway. Meanwhile, Testosterone (T) synthesis disorder affect sexual behavior. However, harmful influence Cd on animal behavior during its growth development role TLR4/MAPK/NF-κB pathway testosterone production remained poorly...
Abstract Background Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS) leads to severe discomfort in males loss of sperm quality. Current therapeutic options have failed achieve satisfactory results. Sodium butyrate (NaB) plays a beneficial role reducing inflammation, increasing antioxidant capacities, improving organ dysfunction; additionally NaB has good safety prospects great potential for clinical application. The purpose the current research was study effect on CP/CPPS...
Cadmium (Cd) is a non-essential heavy metal that highly toxic to testicle. Selenium (Se) known possess antagonistic effects against Cd toxicity, yet the precise mechanisms through which Se counteracts Cd-induced testicular damage in chickens Nuclear factor erythroid 2-related 2/Heme oxygenase-1 (Nrf2/HO-1) signaling pathway, oxidative stress (OS), apoptosis, and inflammation remained unclear. In present study, experimental model of chicken testis was established by incorporating CdCl2...
Abstract Background Chronic prostatitis (CP)/chronic pelvic pain syndrome is the most common urological disorder in young and middle-aged men. A previous study showed that melatonin attenuates prostate inflammation through Sirt1-dependent suppression of nonobese diabetic–like receptor thermal protein domain-associated 3 inflammasome mouse models experimental autoimmune (EAP). However, main differentially expressed proteins (DEPs) melatonin-treated mice with EAP have not yet been fully...
High concentration of blood ammonia can affect the uterus receptivity and decrease fecundity in dairy cow. Melatonin reduce reactive oxygen species (ROS) level has antioxidant anti-inflammatory effects. However, it is not clear whether melatonin alleviate ammonia-induced apoptosis endometrial epithelial cell (EEC) reduced receptivity. The bovine EEC were treated with ammonium chloride and/or melatonin. Cell viability, apoptosis, oxidative stress mitochondrial membrane potential measured...
Abstract Background Chronic prostatitis demonstrates a prevalence rate of nearly 5%–10% among young and middle‐aged individuals, significantly affecting their daily lives. Researchers have obtained significant outcomes investigating the anti‐inflammatory properties itaconic acid (IA) its derivative, 4‐Octyl itaconate (4‐OI), against diverse chronic inflammatory disorders, such as osteoarthritis airway inflammation. Nevertheless, whether IA can also exert effects in requires extensive...
Acute myeloid leukemia (AML) is a common myelogenous malignancy in adults that often characterized by disease relapse. The pathophysiological mechanism of AML has not yet been elucidated. present study aimed to identify the crucial microRNAs (miRNAs/miRs) and target genes AML, uncover potential oncogenic AML. miRNA mRNA expression‑profiling microarray datasets were downloaded from Gene Expression Omnibus database. Differential expression analysis was performed regulatory network between...
Copper Chaperone For Superoxide Dismutase (CCS) genes encode copper chaperone for dismutase (SOD) and dramatically affect the activity of SOD through regulating delivery from target to SOD. is effective component antioxidant defense system in plant cells reduce oxidative damage by eliminating Reactive oxygen species (ROS), which are produced during abiotic stress. CCS might play an important role stress eliminate caused ROS, however, little known about soybean regulation. In this study, 31...
Resolvin D1 (RvD1), a member of the specialized pro-resolving lipid mediators family, has potent anti-inflammatory effect and alleviates tissue damage. The purpose current research was to study RvD1 on CP/CPPS underlying mechanisms using mouse model experimental autoimmune prostatitis (EAP) mice.
Abstract Background Although cystitis glandularis (CG) is a common benign urinary bladder epithelial abnormality, it remains unclear whether CG premalignant lesion. Cyclooxygenase-2 (COX-2) and B-cell lymphoma-2 (Bcl-2) overexpression has recently been reported as potential tumor initiator or promoter. We evaluated compared COX-2 Bcl-2 expression in CG, chronic (CC), primary vesicle adenocarcinoma (ADC) tissues. Methods conducted retrospective study to investigate levels ADC. obtained tissue...