A5100631650- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Sodium Intake and Health
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Gut microbiota and health
- Adipokines, Inflammation, and Metabolic Diseases
- Alzheimer's disease research and treatments
- Gout, Hyperuricemia, Uric Acid
- Asthma and respiratory diseases
- Aquatic Invertebrate Ecology and Behavior
- Wind and Air Flow Studies
- Immunotherapy and Immune Responses
- Leech Biology and Applications
- Cytokine Signaling Pathways and Interactions
- Ecology and biodiversity studies
- Hedgehog Signaling Pathway Studies
- Mechanical stress and fatigue analysis
- Nicotinic Acetylcholine Receptors Study
- Macrophage Migration Inhibitory Factor
- Immune cells in cancer
- Extracellular vesicles in disease
- Gastric Cancer Management and Outcomes
- RNA Research and Splicing
Zhejiang Ocean University
2024
Zhejiang University
2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Gansu University of Traditional Chinese Medicine
2023-2024
Nanjing Agricultural University
2023
Qinghai University
2023
Gansu Provincial Hospital
2023
Southern Medical University
2020-2022
Nanfang Hospital
2021-2022
Abstract Ulcerative colitis (UC) is majorly associated with dysregulation of the dynamic cross-talk among microbial metabolites, intestinal epithelial cells, and macrophages. Several studies have reported significant role butyrate in host–microbiota communication. However, whether provides anti-inflammatory profiles macrophages, thus contributing to UC mucus barrier protection, has currently remained elusive. In current study, we found that increased mucin production proportion...
The extracellular vesicles (EVs) traffic constitutes an essential pathway of cellular communication. And the molecules in EVs produced by procaryotes help maintaining homeostasis, addressing microbial imbalance and infections, regulating immune system. Despite fact that Clostridium butyricum (C. butyricum) is commonly used for treating ulcerative colitis (UC), potential role C. butyricum-secreted commensals-host crosstalk remains unclear.Here, we performed flow cytometry, western blot,...
Abstract DDX39B (also called UAP56 or BAT1) which is a kind of DEAD-box family helicase plays pivotal roles in mRNA binding, splicing, and export. It has been found upregulated many kinds tumors as an oncogene. Nevertheless, the underlying molecular mechanisms proliferation human colorectal cancer (CRC) remain fairly elusive. In our study, function experiments including CCK8 colony formation assay revealed that facilitates CRC vitro. knockdown cells were administered for orthotopic tumor...
Background: Chemoresistance is one of the main causes recurrence in colorectal cancer (CRC) patients and leads to a poor prognosis.To characterize RUNX1 expression elucidate its mechanistic involvement tumor biology this disease.Methods: The CRC normal tissues was detected by bioinformatics analysis.Cell proliferation measured CCK-8 clonogenic assays.In vivo progression assessed with xenograft mouse model.Cell drug sensitivity tests flow cytometry were performed analyze cell...
Abstract Purpose This study aimed to construct an m6A and cuproptosis-related long non-coding RNAs (lncRNAs) signature accurately predict the prognosis of kidney clear cell carcinoma (KIRC) patients using information acquired from The Cancer Genome Atlas (TCGA) database. Methods First, co-expression analysis was performed identify lncRNAs linked with N6-methyladenosine (m6A) cuproptosis in ccRCC. Then, a model encompassing four candidate constructed via univariate, least absolute shrinkage...
Abstract Background Nasopharyngeal carcinoma (NPC), with distinct geographical distribution, has gathered public attention. Despite that radiotherapy and chemotherapy are applied to treat NPC, cell metastasis still cannot be avoided. Numerous works have elucidated lncRNAs essential players in the development of multiple cancers. LncRNA SNHG7 been reported as a contributing factor occurrence certain cancers, but its mechanism NPC deserves further investigation. The purpose study is figure out...
Current approaches are incurable for rheumatoid arthritis (RA). Regulatory T (Treg) cells and helper (Th1 Th17) crucial in controlling the process of RA, which is characterized by inflammatory cell infiltration bone destruction. Carnosol an orthodiphenolic diterpene that has been extensively applied traditional medicine treatment multiple autoimmune diseases. Herein, we indicate administration carnosol dramatically alleviated severity collagen‐induced (CIA) model with a decreased clinical...
Natural ventilation is a way to reduce the energy consumption of building operations and improve indoor living environment comfort. The venturi cap designed with roof, grille wind deflector intensify natural buildings. structural parameters were using an orthogonal design. Fluid analysis software was used for numerical simulation, variance study importance seven influence factors: width roof opening, slope, height deflector, horizontal angle grille, spacing slices. results show that most...
The study explored the effect of miR-30e-5p on nasopharyngeal carcinoma (NPC). MiR-30e-5p levels in NPC cancer and adjacent normal samples, metastatic non-metastatic samples NPC, NP69 cell five lines were determined by quantitative real-time polymerase chain reaction (qRT-PCR). relationship between MTA1 was confirmed dual-luciferase reporter assay, Western blot qRT-PCR. viability, migration invasion 5-8F 6-10B cells CCK-8, scratch test transwell assays, respectively. migration-related...
Adiponectin (APN) is an essential adipokine for a variety of reproductive processes. To investigate the role APN in goat corpora lutea (CLs), CLs and sera from different luteal phases were collected analysis. The results showed that structure content had no significant divergence both sera; however, high molecular weight was dominant serum, while low more present CLs. expression AdipoR1/2 T-cadherin (T-Ca) increased on D11 17. its receptors (AdipoR1/2 T-Ca) mainly expressed steroidogenic...
Conventional nanoelectronic chemical vapor sensors are mostly based on charge transfer mechanisms. The presence of molecules interacts with the sensing material, resulting in changes density channel; conductance change can subsequently be detected as current signals. This transfer-based mechanism naturally requires strong molecule-sensor interaction order to achieve high sensitivity. However, binding analytes sensor surface will inevitably lead slow response time and recovery, making it...
Anchor damage is one of the main risk factors for safe operation submarine cables. Additionally, due to a scour effect induced by seabed currents, cables are prone exposure or even suspension, increasing being dragged anchors. Therefore, it necessary study global response exposed and suspended subjected anchor dragging. In this study, tensile bending stiffnesses calculated theoretical methods, accuracy these calculations verified establishing detailed finite element model. Then, mechanical...
<title>Abstract</title> High salt diet (HSD) is implicated in numerous disorders. HSD boosts Th17 development, compromises the immunosuppressive function of thymic Treg cells leading to exacerbation EAE. However, little known regarding harness excessive proinflammatory responses evoked by HSD. Here we show that atRA, a key vitamin A metabolite with multifaceted immunoregulatory properties has potential HSD-provoked EAE pathogenesis. Treatment atRA <italic>in vivo</italic> elicited generation...
Leeches are an integral component of aquatic biocenosis and can be found in a wide range ecosystems such as freshwater, saltwater, flowing, still-water ecosystems. It especially plays important role the freshwater benthic community is part food web. In this study, leech species was mantle cavity wild mussels Zigong City, Sichuan Province, China, its identity determined through morphological analysis molecular biological analysis.The Hemiclepsis khankiana, new that has been discovered Russia...
Abstract Background : M6A methylation modification of RNA can regulate the development tumor cells. METTL3 is one modified methyltransferases. A growing number studies have shown that high expression may be associated with unfavorable prognosis in cancer patients and become a new biomarker. Therefore, this meta-analysis was used to evaluate prognostic value through available literature information. Methods Relevant were retrieved from electronic databases including six English three Chinese...
SUMMARY Alzheimer’s Disease (AD) is the most prevalent chronic neurodegenerative disease, affecting more than 55 million people worldwide. AD clinically characterized by a progressive loss of memory and other cognitive functions, which implicate cholinergic system. Activity-induced neuroprotection based on gamma oscillation–audiovisual stimuli–is shown to be possible. Bulk RNA-seq data from treatment involving sensory stimuli were obtained, bioinformatics analyses performed. was found...