A5100379320- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Cell death mechanisms and regulation
Hubei University of Chinese Medicine
2022
Guiyang Medical University
2022
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2022
Zaozhuang Municipal Hospital
2020
Abstract Overcoming resistance to alkylating agents has important clinical significance in glioma. Cyanidin-3- O -glucoside (C3G) a tumor-suppressive effect on tumor cells. However, whether it plays role temozolomide glioma is still unclear. We constructed TMZ-resistant LN-18/TR cell line, observed the of C3G TMZ this and explored miR-214-5p chemoresistance. Results showed that β-catenin MGMT were significantly upregulated enhanced cytotoxic Contrarily, downregulated MGMT. Moreover, mimic...
miR-150 expression in osteosarcoma (OS) cell lines and human osteoblast cells was detected, OS models were transfected with exogenous to investigate its role proliferation, invasion, apoptosis. Our results showed that (MG63, Saos-2, SOSP-9607, U2OS) significantly lower compared the hFOB1.19 line (all p < 0.01). The level of MG63 mimics markedly upregulated, while inhibitor group downregulated (both Similar also found SOSP-9607 cells. Importantly, stimulated apoptosis inhibited migration....
The study explored the effect of miR-30e-5p on nasopharyngeal carcinoma (NPC). MiR-30e-5p levels in NPC cancer and adjacent normal samples, metastatic non-metastatic samples NPC, NP69 cell five lines were determined by quantitative real-time polymerase chain reaction (qRT-PCR). relationship between MTA1 was confirmed dual-luciferase reporter assay, Western blot qRT-PCR. viability, migration invasion 5-8F 6-10B cells CCK-8, scratch test transwell assays, respectively. migration-related...
Leukemia accounts for a large number of deaths, worldwide, every year. Treating this ailment is always challenging job. Recently, oncogenic miRNA leading to apoptosis are highly promising targets many natural products. In study, Garmultin-A (GA), isolated from the bark Garcinia multiflora, was elucidated its anti-leukemic effect in CB3 cells.The compound on cell viability detected by MTT assay and FITC Annexin V/PI Hochest 33258 staining. The western blot analysis assessed BAX, BCL2, cMYC,...