Junyi Wang
A5100649301- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Air Quality and Health Impacts
- Genomics and Phylogenetic Studies
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Aquaculture Nutrition and Growth
- Ferroptosis and cancer prognosis
- Crustacean biology and ecology
- Autophagy in Disease and Therapy
- Gut microbiota and health
- Asthma and respiratory diseases
- Chromosomal and Genetic Variations
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Genetic diversity and population structure
- Land Use and Ecosystem Services
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Research in Cotton Cultivation
Southwest Jiaotong University
2017-2025
Wenzhou Medical University
2019-2025
Peking University
2014-2025
Macau University of Science and Technology
2020-2025
Chengdu Third People's Hospital
2017-2025
Tianjin Medical University Cancer Institute and Hospital
2017-2025
Xiamen University
2022-2025
Chongqing Medical University
2015-2025
Wuhan University of Science and Technology
2024-2025
National Clinical Research Center for Digestive Diseases
2025
The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, Mollusca. Here we report sequencing and assembly genome using short reads a fosmid-pooling strategy, along with transcriptomes development stress response proteome shell. is highly polymorphic rich in repetitive sequences, some transposable elements still actively shaping variation. Transcriptome studies reveal an extensive set genes responding environmental stress. expansion...
Polyploidization has provided much genetic variation for plant adaptive evolution, but the mechanisms by which molecular evolution of polyploid genomes establishes architecture underlying species differentiation are unclear. Brassica is an ideal model to increase knowledge evolution. Here we describe a draft genome sequence oleracea, comparing it with that its sister B. rapa reveal numerous chromosome rearrangements and asymmetrical gene loss in duplicated genomic blocks, amplification...
The draft genome of the pear ( Pyrus bretschneideri ) using a combination BAC-by-BAC and next-generation sequencing is reported. A 512.0-Mb sequence corresponding to 97.1% estimated size this highly heterozygous species assembled with 194× coverage. High-density genetic maps comprising 2005 SNP markers anchored 75.5% all 17 chromosomes. encodes 42,812 protein-coding genes, these, ∼28.5% encode multiple isoforms. Repetitive sequences 271.9 Mb in length, accounting for 53.1% genome, are...
Jianquan Liu and colleagues report the draft genome sequence of domestic yak, Bos grunniens. Their comparative analyses with low-altitude cattle provide insights into high-altitude adaptation in yak. Domestic yaks (Bos grunniens) meat other necessities for Tibetans living at high altitude on Qinghai-Tibetan Plateau adjacent regions. Comparison between yak closely related taurus) is informative studying animal to altitude. Here, we present a female generated using Illumina-based technology...
Yu-Xian Zhu, Jun Wang, Shuxun Yu and colleagues report sequencing assembly of the genome cultivated cotton, Gossypium arboreum. Comparison with raimondii sequence provides insights into evolution speciation, identifies two shared whole-genome duplication events occurring before speciation event around 2–13 million years ago. The complex allotetraploid nature cotton (AADD; 2n = 52) makes genetic, genomic functional analyses extremely challenging. Here we sequenced assembled arboreum (AA; 26)...
Zhangjun Fei and colleagues report the draft genome of a Chinese elite watermelon inbred line 97103 resequencing 20 diverse accessions that represent three subspecies Citrullus lunatus. Comparative genome-wide analyses identify extent genetic diversity population structure germplasm. Watermelon, lanatus, is an important cucurbit crop grown throughout world. Here we high-quality sequence east Asia cultivar (2n = 2× 22) containing 23,440 predicted protein-coding genes. genomics analysis...
Sequencing and analysing the diploid genome transcriptome of Aegilops tauschii provide new insights into role this in enabling adaptation bread wheat are a step towards understanding very large complicated hexaploid genomes species. The Triticum aestivum, designated AABBDD, evolved as result hybridization between three ancestral grasses. Two papers published issue Nature present sequences analysis two these progenitors. First, sequence wild T. urartu (ancestor A genome), which resembles...
Significance The two pepper genomes together with 20 resequencing accessions, including 3 accessions that are classified as semiwild/wild, provide a better understanding of the evolution, domestication, and divergence various species ultimately, will enhance future genetic improvement this important worldwide crop.
Completion of genome sequences for the diploid Setaria italica reveals features C4 photosynthesis that could enable improvement polyploid biofuel crop switchgrass (Panicum virgatum). The genetic basis biotechnologically relevant traits, including drought tolerance, photosynthetic efficiency and flowering control, is also highlighted. Foxtail millet (Setaria italica), a member Poaceae grass family, an important food fodder in arid regions has potential use as biofuel. It model system other...
Minsheng You and colleagues report the whole-genome sequence of diamondback moth, Plutella xylostella. Their transcriptome analysis from different life stages, together with comparative genomic phylogenetic analysis, provides insights into herbivore evolution insect adaptation to plant feeding detoxification. How an evolves become a successful is profound biological practical importance. Herbivores are often adapted feed on specific group evolutionarily biochemically related host plants1,...
Prunus mume (mei), which was domesticated in China more than 3,000 years ago as ornamental plant and fruit, is one of the first genomes among subfamilies Rosaceae been sequenced. Here, we assemble a 280M genome by combining 101-fold next-generation sequencing optical mapping data. We further anchor 83.9% scaffolds to eight chromosomes with genetic map constructed restriction-site-associated DNA sequencing. Combining P. available data, succeed reconstructing nine ancestral family, well...
Zhong-Jian Liu, Lai-Qiang Huang, Yi-Bo Luo, Hong-Hwa Chen and Yves Van de Peer report the first genome sequence of a crassulacean acid metabolism (CAM) plant, orchid Phalaenopsis equestris. They identify genes encoding CAM pathway enzymes find that gene duplication was likely key process in evolution photosynthesis. Orchidaceae, renowned for its spectacular flowers other reproductive ecological adaptations, is one most diverse plant families. Here we present tropical epiphytic equestris,...
Long noncoding RNAs (lncRNAs) represent a big category of RNA molecules, and increasing studies have shown that they play important roles in various critical biological processes. They show diversity functions through diverse mechanisms, among which regulating molecules is one the most popular ones. Given number lncRNAs, it becomes urgent to predict targets lncRNAs large scale for comprehensive understanding lncRNA action mechanisms. Although several methods been developed RNA–RNA...
Human utilization of the mulberry–silkworm interaction started at least 5,000 years ago and greatly influenced world history through Silk Road. Complementing silkworm genome sequence, here we describe a mulberry species Morus notabilis. In 330-Mb assembly, identify 128 Mb repetitive sequences 29,338 genes, 60.8% which are supported by transcriptome sequencing. Mulberry gene appear to evolve ~3 times faster than other Rosales, perhaps facilitating species' spread worldwide. The tree is among...
Sesame, Sesamum indicum L., is considered the queen of oilseeds for its high oil content and quality, grown widely in tropical subtropical areas as an important source protein. However, molecular biology sesame largely unexplored.Here, we report a high-quality genome sequence assembled de novo with contig N50 52.2 kb scaffold 2.1 Mb, containing estimated 27,148 genes. The results reveal novel, independent whole duplication absence Toll/interleukin-1 receptor domain resistance Candidate genes...
Tigers and their close relatives (Panthera) are some of the world's most endangered species. Here we report de novo assembly an Amur tiger whole-genome sequence as well genomic sequences a white Bengal tiger, African lion, lion snow leopard. Through comparative genetic analyses these genomes, find signatures that may reflect molecular adaptations consistent with big cats' hypercarnivorous diet muscle strength. We leopard-specific determinant in EGLN1 (Met39>Lys39), which is likely to be...
Thellungiella salsuginea, a close relative of Arabidopsis , represents an extremophile model for abiotic stress tolerance studies. We present the draft sequence T. salsuginea genome, assembled based on ∼134-fold coverage to seven chromosomes with coding capacity at least 28,457 genes. This genome provides resources and evidence about nature defense mechanisms constituting genetic basis underlying plant tolerance. Comparative genomics experimental analyses identified genes related cation...
In the circumstance of global change, studying dynamic changes vegetation and factors that influence it holds immense practical significance to monitor quality regional ecological environment improve structure function ecosystems. Therefore, based on NDVI data, combined with natural anthropogenic activities, this study focused spatiotemporal evolution characteristics stability in Chengdu-Chongqing region from 2001 2020 at multiple scales, quantitatively investigates main influencing driving...
The wild species of the genus Oryza contain a largely untapped reservoir agronomically important genes for rice improvement. Here we report 261-Mb de novo assembled genome sequence brachyantha. Low activity long-terminal repeat retrotransposons and massive internal deletions ancient elements lead to compact We model 32,038 protein-coding in brachyantha genome, which only 70% are located collinear positions comparison with genome. Analysing breakpoints non-collinear suggests that...
Michael Bruford and colleagues report whole-genome sequencing of the peregrine (Falco peregrinus) saker falcon cherrug). Their comparative analysis with five avian species provides insight into evolution adaptation to a predatory lifestyle. As top predators, falcons possess unique morphological, physiological behavioral adaptations that allow them be successful hunters: for example, is renowned as world's fastest animal. To examine evolutionary basis adaptations, we sequenced genomes both...
Exosomes derived from cells have been found to mediate signal transduction between and act as efficient carriers deliver drugs small RNA . Hepatocyte growth factor ( HGF ) is known promote the of both cancer vascular cells, ‐ cMET pathway a potential clinical target. Here, we characterized inhibitory effect si on tumor angiogenesis in gastric cancer. In addition, showed that packed exosomes can be transported into where it dramatically downregulates expression. A cell co‐culture model was...