A5100328644- Genetic Mapping and Diversity in Plants and Animals
- Plant Molecular Biology Research
- Plant Stress Responses and Tolerance
- Plant Gene Expression Analysis
- Genetics and Plant Breeding
- Plant Genetic and Mutation Studies
- Plant Disease Resistance and Genetics
- Plant tissue culture and regeneration
- Genetic and phenotypic traits in livestock
- Plant Reproductive Biology
- Heavy metals in environment
- Photosynthetic Processes and Mechanisms
- Diet and metabolism studies
- Genomics and Phylogenetic Studies
- Seed and Plant Biochemistry
- Epigenetics and DNA Methylation
- Gut microbiota and health
- Plant Micronutrient Interactions and Effects
- Polyamine Metabolism and Applications
- GABA and Rice Research
- RNA modifications and cancer
- Fungal and yeast genetics research
- Bioenergy crop production and management
- Antioxidant Activity and Oxidative Stress
- Bioinformatics and Genomic Networks
Shandong Agricultural University
2020-2025
Hengshui University
2024
China Medical University
2024
Southwest Forestry University
2018-2024
Bioscience (China)
2023-2024
China Pharmaceutical University
2023
Guangzhou Medical University
2020-2022
Sichuan Agricultural University
2011-2021
Academy of Medical Sciences
2018
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
Significance The two pepper genomes together with 20 resequencing accessions, including 3 accessions that are classified as semiwild/wild, provide a better understanding of the evolution, domestication, and divergence various species ultimately, will enhance future genetic improvement this important worldwide crop.
Huntington's disease is caused by expression of a mutant form Huntingtin protein containing an expanded polyglutamine repeat. One possible treatment for may be to reduce in the brain via RNA interference. Unless therapeutic molecule designed allele-specific, both wild-type and will suppressed interference treatment. A key question whether suppression as well targeted regions can tolerated result net benefit patients with disease. Whether performs essential functions adult unclear. Here, we...
Accumulation of cadmium (Cd) in maize (Zea mays L.) poses a significant risk to human health as it is ingested via the food chain. A genome-wide association study (GWAS) was conducted population 269 accessions with 43,737 single nucleotide polymorphisms (SNPs) identify candidate genes and favorable alleles for controlling Cd accumulation maize. When grown contaminated soil, varied significantly leaf concentration at both seeding maturing stages phenotypic variation coefficient all above 48%....
High-throughput sequencing allows for the comprehensive analysis of human intestinal microbiota. However, extensive association analyses between microbiome and lifestyle differences in Chinese population are limited. Here, we carried out an independent cohort study-the Healthy Gut Project (n = 483)-where correlations gut microbiota dietary variables a healthy defined. We collected both questionnaire data, including basic information variables, fecal stools from enrolled volunteers. then...
Lead (Pb) has become one of the most abundant heavy metal pollutants environment. With its large biomass, maize could be an important object for studying phytoremediation Pb‐contaminated soil. In our previous research, we screened 19 inbred lines Pb concentration, and line 178 was identified to a hyperaccumulator in both roots aboveground parts. To identify genes metabolic pathways related accumulation tolerance, underwent genome expression profile under stress control ( CK ). A total...
To safeguard the food supply for growing human population, it is important to understand and exploit genetic basis of quantitative traits. Next-generation sequencing technology performs advantageously effectively in mapping genome analysis diverse resources. Hence, we combined re-sequencing a bin map strategy construct an ultra-high-density with thousands markers precisely trait locus. In this study, generated linkage containing 1,151,856 high quality SNPs between Mo17 B73, which were...
Maize brown midrib (bm) mutants associated with impaired lignin biosynthesis are a potential source for the breed of novel germplasms improved cell wall digestibility. The spontaneous bm5 had been identified since 2008. However, gene responsible locus, and comprehensive effects mutation on biosynthesis, soluble phenolics accumulation, degradation have yet to be elucidated. locus was encode major 4-coumarate: coenzyme A ligase (Zm4CL1) through analyzing MutMap-assisted mapping data. Two...
Diarrhea and constipation are common health concerns in children. Numerous studies have identified strong association between gut microbiota digestive-related diseases. But little is known about the that simultaneously affects both diarrhea or their potential regulatory mechanisms. Stool samples from 618 children (66 diarrhea, 138 constipation, 414 healthy controls) aged 0-3 years were collected to investigate changes using 16S rRNA sequencing. Compared with healthy, exhibited a significant...
Maize is one of the most important cereal crops worldwide and primary targets genetic manipulation, which provides an excellent way to promote its production. However, obvious difference dedifferentiation frequency immature maize embryo among various genotypes indicates that transformation dependence on genotype embryo-derived undifferentiated cells. To identify genes metabolic pathways involved in forming embryonic calli, this study, DGE (differential gene expression) analysis was performed...
Plants adapt to adverse conditions through a series of physiological, cellular, and molecular processes, culminating in stress tolerance. However, little is known about the associated regulatory mechanisms at epigenetic level maize under lead (Pb) stress. Therefore, this study, we aimed compare DNA methylation profiles during dynamic development roots following Pb treatment identify candidate genes involved response Methylated immunoprecipitation-sequencing (MeDIP-seq) was used investigate...
Genomic selection is a promising research area due to its practical application in breeding. In this study, impact of realized genetic relationship and linkage disequilibrium (LD) on marker density training population size required was investigated their further discussed. This study based experimental data two populations derived from the same founder lines (B73, Mo17). Two were genotyped with different sets at density: IBM Syn4 Syn10. A high-density set Syn10 imputed into low density....
In this study, a maize inbred line with strong capacity to induce embryonic callus, 18‐ 599R , was used analyze the transcription factors expressed during callus formation. A total of 1180 were found be three key stages induction. Of these, compared control, 361, 346 and 328 significantly downregulated I, II III respectively. contrast, 355, 372 401 ( TFs ) upregulated respective stages. We constructed factor‐mediated regulatory network that plant hormone signal transduction pathway most...
SUMMARY Maize is an important crop worldwide, as well a valuable model with vast genetic diversity. Accurate genome and annotation information for wide range of inbred lines would provide resources improvement pan‐genome characterization. In this study, we generated high‐quality de novo assembly (contig N50 15.43 Mb) the Chinese elite line RP125 using Nanopore long‐read sequencing Hi‐C scaffolding, which yield highly contiguous, chromosome‐length scaffolds. Global comparison those B73, W22,...
SUMMARY Carotenoids perform a broad range of important functions in humans; therefore, carotenoid biofortification maize ( Zea mays L.), one the most highly produced cereal crops worldwide, would have global impact on human health. PLASTID TERMINAL OXIDASE PTOX ) genes play an role metabolism; however, possible function biosynthesis has not yet been explored. In this study, we characterized locus by forward‐ and reverse‐genetic analyses. While higher plant species possess single copy gene,...
SUMMARY DNA methylation plays an essential role in plant growth and development, however, its specific influence on maize kernel development remains uncertain. In this study, we investigated the gene responsible for mutant smk313 identified it as methyltransferase ZmMET1. The mutants displayed a distinct small phenotype exhibited developmental abnormalities basal endosperm transfer layer (BETL), adjacent to scutellum cell (EAS), starchy cells (SEs). Compared with that of wild‐type (WT),...
Abstract Background Leptospira interrogans is an important mammalian pathogen. Transmission from environmental source requires adaptation to a range of new conditions in the organs and tissues infected host. Several studies have shown that shift culture temperature 28°C 37°C, similar encountered during infection host source, associated with differential synthesis several proteins outer membrane, periplasm cytoplasm. The whole genome serogroup Icterohaemorrhagiae serovar lai type strain...
Prostate cancer poses a public health threat to hundreds of people around the world. p62 has been identified as tumor suppressor, however, mechanism by which promotes prostate remains poorly understood. The present study aimed investigate whether proliferation, apoptosis resistance and invasion cells via Kelch‑like ECH‑associated protein 1/nuclear factor erytheroid‑derived 2‑like 2/antioxidant response element (Keap1/Nrf2/ARE) axis. Immunohistochemical staining immunoblotting were performed...