A5100376356- Synthesis and biological activity
- Metal complexes synthesis and properties
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystal structures of chemical compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Magnetism in coordination complexes
- Molecular Sensors and Ion Detection
- Click Chemistry and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Synthesis and Biological Evaluation
- Sulfur Compounds in Biology
- Microbial Applications in Construction Materials
- Computational Drug Discovery Methods
- Cancer therapeutics and mechanisms
- Quinazolinone synthesis and applications
- Metal-Catalyzed Oxygenation Mechanisms
- Microbial Natural Products and Biosynthesis
- HER2/EGFR in Cancer Research
- Nanoplatforms for cancer theranostics
- Melanoma and MAPK Pathways
- Synthesis of Organic Compounds
- Lanthanide and Transition Metal Complexes
- Advanced biosensing and bioanalysis techniques
- Inflammatory mediators and NSAID effects
Nanjing University
2016-2025
Jishou University
2014-2024
Shanghai Tunnel Engineering (China)
2022-2024
Zhengzhou Children's Hospital
2019-2023
Zhengzhou University
2019-2023
State Key Laboratory of Pharmaceutical Biotechnology
2009-2023
Pharmaceutical Biotechnology (Czechia)
2014-2023
Changshu No.1 People's Hospital
2021-2023
Soochow University
2021-2023
Chongqing University
2022
Chiral squaramides are highly enantioselective catalysts for Friedel–Crafts reaction of indoles with N-tosyl imines, affording 3-indolyl methanamine products in 85–96% yields and 84–96% ees.
Myeloperoxidase (MPO)-mediated oxidative stress has been suggested to play an important role in the pathological dysfunction of epileptic brains. However, there is currently no robust brain-imaging tool detect real-time endogenous hypochlorite (HClO) generation by MPO or a fluorescent probe for rapid high-throughput screening antiepileptic agents that control MPO-mediated chlorination stress. Herein, we report efficient two-photon fluorescence (named HCP) detection HClO signals generated...
A series of 1,2,3-triazole phenylhydrazone derivatives were designed and synthesized as antifungal agents.
Abstract Epilepsy is a chronic neurodegenerative disease, and accumulating evidence suggests its pathological progression closely associated with peroxynitrite (ONOO − ). However, understanding the function remains challenging due to lack of in vivo imaging probes for ONOO determination epileptic brains. Here, first near‐infrared probe (named ONP) presented tracking endogenous brains kainate‐induced seizures high sensitivity selectivity. Using this probe, dynamic changes fluxes are...
The abnormal angiogenesis and insufficient oxygen supply in solid tumors lead to intratumoral hypoxia, which severely limits the efficacy of traditional photodynamic therapy (PDT). Here, a multifunctional nanoplatform (ZDZP@PP) based on zeolitic imidazolate framework-67 (ZIF-67) core as hydrogen peroxide catalyst, framework-8 (ZIF-8) shell with pH-responsive property, polydopamine–poly(ethylene glycol) (PDA–PEG) layer for improving biocompatibility is fabricated not only relieving tumor...
Responsive nanocarriers with biocompatibility and precise drug releasing capability have emerged as a prospective candidate for anticancer treatment. However, the challenges imposed by complicated preparation process limited loading capacities seriously impeded development of novel multifunctional delivery systems. Here, we developed dual-responsive nanocarrier based on nanoscale ZIF-8 core an organosilica shell containing disulfide bridges in its frameworks through facile efficient...