A5040341808- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Synthesis and biological activity
- Metal-Organic Frameworks: Synthesis and Applications
- Inflammatory mediators and NSAID effects
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Photodynamic Therapy Research Studies
- Synthesis and Reactions of Organic Compounds
- Nanoparticle-Based Drug Delivery
- Cancer, Hypoxia, and Metabolism
- Microbial Applications in Construction Materials
- Synthesis and Biological Evaluation
- Helicobacter pylori-related gastroenterology studies
- Photoacoustic and Ultrasonic Imaging
- Advanced Computational Techniques and Applications
- Carbohydrate Chemistry and Synthesis
- Advanced Sensor and Control Systems
- Supramolecular Chemistry and Complexes
- Cell Adhesion Molecules Research
- Nitric Oxide and Endothelin Effects
- Ultrasound and Hyperthermia Applications
- Ferrocene Chemistry and Applications
Hebei University of Technology
2020-2025
Hebei University of Economics and Business
2025
Institute of Biophysics
2020-2024
Nanjing University
2016-2021
Hospital of Hebei Province
2021
Sino Biological (China)
2017
The abnormal angiogenesis and insufficient oxygen supply in solid tumors lead to intratumoral hypoxia, which severely limits the efficacy of traditional photodynamic therapy (PDT). Here, a multifunctional nanoplatform (ZDZP@PP) based on zeolitic imidazolate framework-67 (ZIF-67) core as hydrogen peroxide catalyst, framework-8 (ZIF-8) shell with pH-responsive property, polydopamine–poly(ethylene glycol) (PDA–PEG) layer for improving biocompatibility is fabricated not only relieving tumor...
Responsive nanocarriers with biocompatibility and precise drug releasing capability have emerged as a prospective candidate for anticancer treatment. However, the challenges imposed by complicated preparation process limited loading capacities seriously impeded development of novel multifunctional delivery systems. Here, we developed dual-responsive nanocarrier based on nanoscale ZIF-8 core an organosilica shell containing disulfide bridges in its frameworks through facile efficient...
Photodynamic therapy (PDT) under hypoxic conditions and drug resistance in chemotherapy are perplexing problems anti-tumor treatment. In addition, central nervous system neoplasm-targeted nanoplatforms urgently required. To address these issues, a new multi-functional protein hybrid nanoplatform is designed, consisting of transferrin (TFR) as the multicategory solid tumor recognizer hemoglobin for oxygen supply (ODP-TH). This framework encapsulates photosensitizer protoporphyrin IX (PpIX)...
In this work, a photoacoustic (PA) probe, HDS-GGT, was developed for the in vivo imaging of cardiovascular diseases by monitoring γ-glutamyl transferase (GGT) dynamics. HDS-GGT exhibited stable PA signal with auxiliary absorbance and NIRF variation after trigger GGT. all three modalities absorbance, NIRF, PA, could quantitatively reflect GGT level. modality, indicated practical advantages including high sensitivity, stability, specificity. living oxidized low-density lipoprotein-induced...
Glioblastoma is the most fatal and insidious malignancy, due to existence of blood–brain barrier (BBB) high invasiveness tumor cells.
A versatile nanoplatform could realize a catalytic cascade reaction in tumor microenvironment, and thus, relieve hypoxia enhance PDT efficacy.
Recently, the development of multifunctional nanoplatforms for synergistic therapy is highly attractive in cancer treatment. Herein, a cell membrane-coated biomimetic nanoplatform (termed as mPAGT) was designed through simple and versatile polyphenol-mediated coating strategy catalytic cascades-enhanced tumor targeted combination therapy. Porphyrin MOFs (PCN) were selected nano-photosensitizer then an endogenous nitric oxide (NO) donor l-arginine (l-Arg) loaded into framework to obtain PA...
Glioblastoma is the most concealment malignant intracranial tumor, because of tumor heterogeneity and obstruction blood-brain barrier (BBB). Peroxynitrite (ONOO-) an extremely strong oxidant, it a biomarker closely related to cancer. Real-time monitoring ONOO- level in glioma significant for initial diagnosis. Herein, we have developed new-type enhanced fluorescent probe, ZONQ, with superior rapid response specific selectivity towards ONOO-, even coexistence ROS biologically species. Based...