A5100383833- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Urological Disorders and Treatments
- Total Knee Arthroplasty Outcomes
- Liver Disease and Transplantation
- Urinary and Genital Oncology Studies
- Healthcare and Venom Research
- Herpesvirus Infections and Treatments
- Traditional Chinese Medicine Analysis
- Drug Transport and Resistance Mechanisms
- Diabetic Foot Ulcer Assessment and Management
- Bone and Joint Diseases
- Wound Healing and Treatments
- Immune Response and Inflammation
- Urinary Bladder and Prostate Research
- Pediatric Urology and Nephrology Studies
- Bone health and treatments
- Traditional Chinese Medicine Studies
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Tissue Engineering and Regenerative Medicine
- Drug-Induced Hepatotoxicity and Protection
- Mesenchymal stem cell research
- Kidney Stones and Urolithiasis Treatments
OriginWater (China)
2024
Beijing Children’s Hospital
2019-2024
Capital Medical University
2019-2024
Dali University
2024
Jinan University
2019-2024
Macau University of Science and Technology
2024
Peking University Shenzhen Hospital
2012-2024
Shenzhen University
2024
Shanghai Pudong New Area Gongli Hospital
2024
Second Military Medical University
2024
The safety of the immune complexes composed yeast-derived hepatitis B surface antigen (HBsAg) and antibodies (abbreviated as YIC) among healthy adults chronic patients has been proved in phase I IIa trial. A larger number for study dosage efficacy are therefore needed.Two hundred forty two HBeAg-positive were immunized with six injections either 30 microg YIC, 60 YIC or alum adjuvant placebo at four-week intervals under code. HBV markers DNA monitored during immunization 24 weeks after...
Haploidentical hematopoietic stem-cell transplantation (haplo-HSCT) is associated with an increased risk of graft failure and severe graft-versus-host disease (GVHD). Mesenchymal stromal cells (MSCs) have been shown to support in vivo normal hematopoiesis display potent immunesuppressive effects. We cotransplanted the culture-expanded third-party donor-derived umbilical cord MSCs (UC-MSCs) 21 young people aplastic anemia (SAA) undergoing haplo-HSCT without T-cell-depleted. observed that all...
The carcinogenic capacity of B[a]P/B[a]PDE is supported by epidemiologic studies. However, the molecular mechanisms responsible for B[a]P/B[a]PDE-caused lung cancer have not been well investigated. We evaluated here role novel target PHLPP2 in inflammation and carcinogenesis upon exposure.We used Western blotting, RT-PCR, [(35)S]methionine pulse immunohistochemistry staining to determine downregulation following exposure. Both B[a]PDE-induced Beas-2B cell transformation model B[a]P-caused...
The StAR-related lipid transfer (START) domain, first identified in the steroidogenic acute regulatory protein (StAR), is involved intracellular trafficking of lipids. Sixteen mammalian START domain-containing proteins have been to date. StAR, a targeted mitochondria, stimulates movement cholesterol from outer inner mitochondrial membranes, where it metabolized into pregnenolone cells. MLN64, domain most closely related localized late endosomes along with other sterol trafficking, including...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease recently discovered in northeastern and central China that caused by a novel bunyavirus, severe virus (SFTSV). Humans are primarily infected through tick bites. Four previous reports have discussed SFTS infection from person to person, all cases of which were symptomatic. In this report, we analysed the epidemiological clinical data for cluster cases, including one case secondary-asymptomatic infection,...
Significance Speech and bipedalism are key aspects of behavior that emerged during human evolution. FOXP2 , a gene implicated in speech language disorder, has been suggested to contribute Here, through knockout studies mouse Foxp2 we show this is not only important for neural circuits involved vocal behaviors, it also helps regulate relevant anatomical substrates. We additionally demonstrate influences skeletal features may be bipedal locomotion. Our findings raise the possibility might...
To improve liposome-directed therapy of liver disease and gene delivery, it would be beneficial to selectively target hepatocytes. For this purpose, conventional liposomes (CL) were labeled with asialofetuin (AF), an asialoglycoprotein. The biodistribution AF-labeled (AF-L) in mice their incorporation into rat hepatocytes, potential use acute injury, investigated. AF-L displayed a quicker plasma clearance than CL, 25.4%, 2.7%, 1.2% the injected dose remained versus 47.0%, 26.1%, 9.5%...
Salvia miltiorrhiza (SM) contains four major aqueous active ingredients, which have been isolated, purified and identified as danshensu (DSS), salvianolic acid A (Sal-A), B (Sal-B) protocatechuic aldehyde (PAL), totally abbreviated SABP. Although SM is often used to treat various cardiovascular diseases in traditional Chinese medicine, the efficacy function of optimal compatibility ratio SM's ingredients (SABP) prevention treatment remain uncertain. This study investigated antihypertensive...
Glucocorticoid (GC) administration is one of the main causes osteonecrosis femoral head (ONFH). Inflammation, especially TLR4/NF-κB pathway, has been demonstrated to play a pivotal role in pathogenesis GC-induced ONFH. Calycosin, bioactive extract Astragali Radix, could substantially regulate pathway. Therefore, this study, we hypothesized that calycosin exert beneficial effects In vitro, on osteogenic differentiation human bone mesenchymal stem cells (hBMSCs) were determined using Alizarin...
Abstract The purpose of this study is to investigate the predictive value neutrophil‐to‐lymphocyte ratio (NLR), serum calcium, and albumin on prognosis patients with diabetic foot. A total 156 who were treated in Department Burn Plastic Surgery Qilu Hospital Shandong University from 1 January 2014 August 2020 selected. All randomly divided into a healing group, minor amputation major death group according their treatment outcomes. levels NLR, calcium each examined compared. correlations...
Angelica sinensis is a medicinal plant widely used to treat multiple diseases in Asia and Europe, which contains numerous active components with therapeutic value. The interaction between root rhizosphere microorganisms crucial for the growth quality formation of plants. But micro-plant-metabolite regulation patterns A. remain largely undetermined. Here, we collected roots soils from seedling stage (M) picking (G), respectively cultivated one year two years, generated metabolite roots,...
Cell therapy by autologous mesenchymal stem cells (MSCs) is a clinically acceptable strategy for treating various diseases. Unfortunately, the therapeutic efficacy largely affected low quality of MSCs collected from patients. Here, we showed that gene expression patients with diabetes was differentially regulated compared to healthy controls. Then, were genetically engineered catalyze an NO prodrug release intracellularly. Compared extracellular conversion, intracellular delivery effectively...
Objectives Cerebral edema is a major cause of death during acute liver failure (ALF), but the exact mechanism this condition still not entirely clear. The aim study was to investigate role tumor necrosis factor α (TNFα) in changing permeability blood–brain barrier (BBB) acetaminophen (APAP)-induced ALF. Materials and methods ALF animal models were generated by administering APAP. Anti-TNFα-IgG intravenously injected (100 μg/mouse) 2 h after administration We investigated BBB with Evans blue...