A5076940713- Nanoparticle-Based Drug Delivery
- Reproductive System and Pregnancy
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Hippo pathway signaling and YAP/TAZ
- Conducting polymers and applications
- Advanced Sensor and Energy Harvesting Materials
- Advanced biosensing and bioanalysis techniques
- Fuel Cells and Related Materials
- Endometriosis Research and Treatment
- Virus-based gene therapy research
- Pregnancy and preeclampsia studies
- Axon Guidance and Neuronal Signaling
- Nutrition and Health in Aging
- RNA modifications and cancer
- Biochemical and Structural Characterization
- Wound Healing and Treatments
- Electrocatalysts for Energy Conversion
- Generative Adversarial Networks and Image Synthesis
- Advanced Image Processing Techniques
- Chemical Synthesis and Analysis
- Hepatitis B Virus Studies
- Membrane-based Ion Separation Techniques
- Cancer-related gene regulation
- Silk-based biomaterials and applications
Chongqing Institute of Green and Intelligent Technology
2022-2025
University of Chinese Academy of Sciences
2022-2025
Tongji University
2018-2024
Jiangsu University
2021-2024
Wuhan University of Technology
2024
Shanghai First Maternity and Infant Hospital
2017-2023
Institute of Software
2022
Chinese Academy of Sciences
2022
Mudanjiang Medical University
2021
Xinyang Normal University
2013-2019
Abstract For various chronic wounds, bacterial infection is one of the important reasons that hinder their healing. Ion‐crosslinked antibacterial hydrogel dressings based on Ag + , Cu 2+ and Zn have made progress in clinical application. However, toxicity released metal ions cannot be ignored. Therefore, how to ensure performance dressing while reducing amount a major challenge for fabrication ion hydrogel. In this study, general method proposed design cationic ion‐crosslinked thiourea...
The aim of this study was to obtain adriamycin-loaded polymer-lipid hybrid nanoparticles conjugated with anti-EGF receptor antibody (PLNP-Mal-EGFR) for hepatocellular carcinoma (HCC) chemotherapy.The were characterized by dynamic light scattering and fluorescence spectroscopy. in vitro vivo distribution anti-tumor activity the evaluated.PLNP-Mal-EGFR showed significantly enhanced cellular cytotoxicity against HCC cells overexpressing EGFR compared nontargeted (polymer-lipid [containing...
Flexible and wearable strain sensors have received extensive attention in the preparation of human–machine interface equipment, intelligent robots, personalized health-monitoring biosensors. However, it has been a formidable challenge to develop materials with satisfying stretchability, sharp quick sensitivity, good linearity. Herein, we report multifunctional nanocomposite hydrogel outstanding fatigue resistance, electrical conductivity by adding Ag nanoparticle-coated graphene oxide...
Abstract Despite the immense potential of immune checkpoint blockade (ICB) therapy in tumor treatment, its widespread clinical application is currently limited by unsatisfactory curative effect and off‐target adverse effect. Herein, an injectable sericin (SS)/silk fibroin (SF) recombinant hydrogel, termed SF‐SS‐SMC developed to enable local delivery anti‐CD47 antibody (α CD47). The hydrogel displays self‐reinforcement high H 2 O concentration microenvironment (TME), as SS/Fe 2+...
Abstract Flexible conductive materials and flexible electronic devices are driving the development of next generation cutting‐edge wearable electronics. However, existing hydrogel‐based have limited tensile capacity, low toughness, poor anti‐fatigue performance, resulting in narrow sensing area insufficient durability. In this paper, a nanocomposite hydrogel with high ductility, fatigue resistance is prepared by combining silver coated copper (Ag@Cu) nanoparticles gelatin followed one‐step...
Breast cancer remains a significant global health challenge, emphasizing the pressing need for innovative therapeutic approaches. Our thorough research investigates potential of mesoporous polydopamine nanoparticles (MPDA) as targeted treatment breast cancer. Meticulously crafted, these were loaded with honokiol (HK), which is natural product, and then coated functionalized hyaluronic acid (HA) to boost their ability target cells that overexpress CD44 receptors. The deep penetrating...
To label proteins covalently, one faces a trade-off between labeling protein specifically and using small tag. Often must compromise parameter for the other or use additional components, such as an enzyme, to satisfy both requirements. Here, we report new reaction that covalently labels by engineered coiled-coil peptides. Harnessing concept of "proximity-induced reactivity", 21-amino-acid three-heptad peptides CCE/CCK were modified with nucleophilic cysteine α-chloroacetyl group at selected...
Conventional antibody-based targeted cancer therapy is one of the most promising avenues successful treatment, with potential to reduce toxic side effects healthy cells surrounding tumor cells. However, full antibodies severely limited due their large size, low stability, slow clearance, and high immunogenicity. Alternatively, recently discovered nanobodies, which are smallest naturally occurring antigen-binding format, have shown great for addressing these limitations. Bioconjugation...
As an ideal drug carrier, it should possess high loading and encapsulation efficiency precise targeting release. Herein, we utilized a template-guided self-weaving technology of phase-separated silk fibroin (SF) in reverse microemulsion (RME) to fabricate kind hyaluronic acid (HA) coated SF nanocage (HA-gNCs) for delivery cancer immunotherapy. Due the hollow structure, HA-gNCs were capable simultaneous anti-inflammatory betamethasone phosphate (BetP) immune checkpoint blockade (ICB) agent...
Targeted covalent inhibitors of protein-protein interactions differ from reversible in that the former bind and covalently bond target protein at a specific site target. The specificity is result proximity two reactive groups bound state, for example, one mild electrophile inhibitor natural cysteine close to ligand binding site. Only few pharmaceutically relevant proteins have this structural feature. Grb2, key adaptor maintaining ERK activity via Sos1 activated RTKs, one: N-terminal SH3...
Intracellular reactions on nonenzymatic proteins that activate cellular signals are rarely found. We report one example here a designed peptide derivative undergoes nucleophilic reaction specifically with cytosolic PDZ protein inside cells. This led to the activation of ephrin-B reverse signaling, which subsequently inhibited SDF-1 induced neuronal chemotaxis human neuroblastoma cells and mouse cerebellar granule neurons. Our work provides direct evidence PDZ-RGS3 bridges signaling G for first time.
The small molecule drug 5-fluorouracil (5-FU) is widely used in the treatment for gastric cancer (GC), however, it exerts poor efficacy and associated with acquired intrinsic resistance. Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, plays key role adhesion, migration, proliferation of carcinoma cells, suggesting that this may be promising therapeutic target. Differentially expressed FAK GC tissue was detected by RT-qPCR TCGA database analysis. To investigate biological...
Abstract Mesoporous materials have recently gained much attention owing to their large surface area, narrow pore size distribution, and superior structure. These been demonstrated as excellent solid supports for immobilization of a variety proteins enzymes potential applications biocatalysts in the chemical pharmaceutical industries. However, lack efficient reproducible methods has limited activity recyclability these biocatalysts. Furthermore, are usually not robust rapid denaturation bulk...