A5008386847- Ovarian function and disorders
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- MicroRNA in disease regulation
- RNA modifications and cancer
- Reproductive System and Pregnancy
- Chromatography in Natural Products
- Cancer-related molecular mechanisms research
- Cytomegalovirus and herpesvirus research
- Magnetic and Electromagnetic Effects
- Circular RNAs in diseases
- Biofield Effects and Biophysics
- Pharmacological Effects of Natural Compounds
- Cancer Research and Treatments
- Biochemical Analysis and Sensing Techniques
- Gastrointestinal Tumor Research and Treatment
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Endometriosis Research and Treatment
- Metastasis and carcinoma case studies
- Metabolism, Diabetes, and Cancer
- Gastric Cancer Management and Outcomes
- Ear and Head Tumors
Monash University
2022-2025
Third People's Hospital of Yunnan Province
2025
Pudong Medical Center
2025
Fudan University
2025
Chongqing University
2022-2025
Anhui Provincial Hospital
2025
First People's Hospital of Chongqing
2021-2024
Shanghai Electric (China)
2024
Suzhou Municipal Hospital
2016-2024
Nanjing Medical University
2013-2024
Abstract Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes centenarians, whose genomes may harbor genetic variants health and longevity. Here we report a association study (GWAS) Han Chinese size 2.7 times the largest previously published GWAS on centenarians. We 11 independent replicated in Southern-Northern regions China, including novel (rs2069837- IL6 ; rs2440012- ANKRD20A9P ) significance rest...
Background: Myeloid-derived suppressor cells (MDSCs) promote immunosuppression in the tumor microenvironment, support growth and survival, may contribute to immunotherapy resistance. Recent studies showed that tumor-derived exosomes (TDEs) can induce MDSCs accumulation expansion, mechanisms of which are largely unknown. Methods: The morphologies sizes was observed by using a JEM-1400 transmission electron microscope. MicroRNA(miR)-107 ARG1, DICER1, PTEN, PI3K, AKT, mTOR, NF-kB mRNAs were...
Background Polycystic ovarian syndrome (PCOS) is a common endocrine disorder characterized by hyperandrogenism, dysfunction and polycystic morphology. Gut microbiota dysbiosis metabolite are associated with PCOS clinical parameters. Yulin Tong Bu formula (YLTB), traditional Chinese medicine formula, has been recently indicated to be capable of ameliorating ovary symptoms correcting abnormal glucose metabolism. However, the therapeutic mechanism YLTB on not fully elucidated. Methods A pseudo...
This study aimed to investigate the effect and possible underlying mechanisms of high-fat diet-induced obesity on spermatogenesis in male rats.A total 45 rats were randomly divided into control (n = 15, normal diet) groups 30, fed for 16 weeks. Body weight organ indexes determined after sacrifice. Indicators reproductive function, including sperm count, motility, apoptosis spermatogenic cells, oxidative stress levels, measured. Serum metabolic parameters hormones also assayed.Compared with...
Can exposure to palmitic acid (PA), a common saturated fatty acid, modulate autophagy in both human and mouse trophoblast cells through the regulation of acyl-coenzyme A-binding protein (ACBP)?
<title>Abstract</title> Background Venous thromboembolism (VTE) is a significant complication among perinatal women. However, current tools for assessing VTE prevention are not suitable pregnant In this study, we aim to develop and validate knowledge, attitude practice (VTE-KAP) questionnaire tailored population. Methods This study was conducted in two phases. Phase 1 involved creating preliminary item pool through literature review group discussions, followed by expert consultations...
This study aims to investigate the effects of preoperative intracerebral hematoma volume (HVpre), 6-8 days post-surgery (HVpost), and rate change (HVpre-HVpost)/HVpre on prognosis patients with aneurysmal subarachnoid hemorrhage (aSAH). CT imaging data from 62 aSAH admitted our hospital's Neurosurgery Department between January 2022 December 2023 were obtained, both preoperatively postoperatively. The volumes measured using 3D-Slicer. Patients' recovery at 3 months post-discharge was...
Rationale: The ultrasensitive and accurate detection of driver mutations is critical for early cancer screening precision medicine. Current methods face challenges in balancing sensitivity, specificity, speed, which limits their clinical utility. Therefore, a rapid, sensitive, specific method essential detecting cancer-related SNPs. Methods: This study introduces SPEAR (Specific Point mutation Evaluation via CRISPR-Cas Assisted Recognition), novel methodology combining NEAR (Nicking Enzyme...
Breast cancer remains a significant global health challenge, emphasizing the pressing need for innovative therapeutic approaches. Our thorough research investigates potential of mesoporous polydopamine nanoparticles (MPDA) as targeted treatment breast cancer. Meticulously crafted, these were loaded with honokiol (HK), which is natural product, and then coated functionalized hyaluronic acid (HA) to boost their ability target cells that overexpress CD44 receptors. The deep penetrating...
Abstract Background GPRIN1 may be a novel tumor regulator, but its role and mechanism in tumors are still unclear. Methods First, pan‐cancer correlation analysis was conducted on the expression prognosis of based data downloaded from The Cancer Genome Atlas (TCGA) database. Second, Starbase database used to predict upstream miRNAs lncRNAs GPRIN1, analysis, survival were performed screen microRNA (miRNAs)/long non‐coding RNAs (lncRNAs) that had with kidney renal papillary cell carcinoma...
Abstract Background: Astilbin is a flavonoid isolated from the rhizome of Smilax glabra. In previous study, we revealed its unique immunosuppressive activity, selective inhibition against activated T lymphocytes. This characteristic astilbin beneficial for treatment human immune diseases. Methods: We incubated with rat liver microsomal/cytosolic fractions and metabolite astilbin, which was fully characterized by mass spectrometry (MS) nuclear magnetic resonance (NMR) spectroscopy....
Background: Metastasis and recurrence are the main causes of death from cervical cancer (CC), thus it is important to identify more effective biomarkers improve its prognosis. The purpose our research was determine potential role autophagy-related long non-coding RNA (lncRNA) in CC construct an lncRNA signature for survival CC. Methods: lncRNAs were downloaded Cancer Genome Atlas (TCGA) database, identified through co-expression genes autophagy genes. Several with prognostic value...
The aim of this study was to determine the impact glycyrrhizin, an inhibitor high mobility group box 1, on glucose metabolic disorders and ovarian dysfunction in mice with polycystic ovary syndrome. We generated a syndrome mouse model by using dehydroepiandrosterone plus high-fat diet. Glycyrrhizin (100 mg/kg) intraperitoneally injected into effects body weight, tolerance, insulin sensitivity, estrous cycle, hormone profiles, pathology, glucolipid metabolism, some molecular mechanisms were...
Myeloid-derived suppressor cells (MDSCs) are a group of heterogeneous derived from immature myeloid (IMCs). MDSCs known to play important roles in tumor immune evasion. While we know that there large number circulating and tumor-infiltrating existing gastric cancer (GC) patients, the phenotypic characteristics arginase 1 (ARG1) expression levels these remain very unclear. In our study, flow cytometric analysis 20 adenocarcinoma (GAC) patients found ≥80% ARG1-expressing were mainly...
Decorin exhibits inhibitory effects in tumorigenesis various types of cancers. The clinical characteristics 42 patients with GBM were reviewed and analyzed. Lentiviral constructs for decorin overexpression shRNA-mediated silencing established U87MG cells T98G cells, respectively. expressions EMT- autophagy-associated markers detected cell lines. migration invasion the glioma assayed to reflect malignant behavior GBM. A mouse xenograft model was used verify effect on autophagy vivo . Reduced...