A5045170572- Pregnancy and preeclampsia studies
- RNA modifications and cancer
- Geochemistry and Geologic Mapping
- Geological and Geochemical Analysis
- Gas Sensing Nanomaterials and Sensors
- Epigenetics and DNA Methylation
- earthquake and tectonic studies
- Advanced Chemical Sensor Technologies
- Birth, Development, and Health
- Ovarian function and disorders
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Analytical Chemistry and Sensors
- SARS-CoV-2 and COVID-19 Research
- Quantum Dots Synthesis And Properties
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cardiac electrophysiology and arrhythmias
- Advanced Chemical Physics Studies
- Cancer-related gene regulation
- Hepatitis C virus research
- Chalcogenide Semiconductor Thin Films
- Cardiovascular Function and Risk Factors
- Catalytic Processes in Materials Science
- Liver Disease Diagnosis and Treatment
Chongqing Medical University
2013-2025
Children's Hospital of Chongqing Medical University
2023-2025
Changsha Medical University
2023-2025
Xiamen University
2020-2025
Guilin Medical University
2024-2025
Deyang Stomatological Hospital
2024
Wuhan Institute of Technology
2022-2024
Shandong Normal University
2023-2024
Io Therapeutics (United States)
2024
Xi'an Jiaotong University
2023-2024
Oxidation of 5-methylcytosine in DNA by ten-eleven translocation (Tet) family enzymes has been demonstrated to play a significant role epigenetic regulation mammals. We found that Tet also possess the activity catalyzing formation 5-hydroxymethylcytidine (5-hmrC) RNA vitro. In addition, catalytic domains all three as well full-length Tet3 could induce 5-hmrC human cells. Moreover, was present at appreciable levels (∼1 per 5000 5-methylcytidine) mammalian cells and tissues. Our results...
Doxorubicin is one of the most widely used chemotherapy agents for treatment breast cancer. However, development doxorubicin resistance limits long‑term benefits in patients with Curcumin, a well‑known dietary polyphenol derived from rhizomes turmeric (Curcuma longa), enhances sensitivity cancer cells to chemotherapeutic agents; however, mechanisms underlying this phenomenon remain unclear. The aim present study was evaluate effect curcumin on chemoresistance doxorubicin‑resistant...
Background Polycystic ovarian syndrome (PCOS) is a common endocrine disorder characterized by hyperandrogenism, dysfunction and polycystic morphology. Gut microbiota dysbiosis metabolite are associated with PCOS clinical parameters. Yulin Tong Bu formula (YLTB), traditional Chinese medicine formula, has been recently indicated to be capable of ameliorating ovary symptoms correcting abnormal glucose metabolism. However, the therapeutic mechanism YLTB on not fully elucidated. Methods A pseudo...
Neural stem cell (NSC) transplantation has been proposed as a future therapy for neurodegenerative disorders. However, NSC will be hampered by the limited number of brain donors and toxicity immunosuppressive regimens that might needed with allogeneic transplantation. These limitations may avoided if NSCs can generated from clinically accessible sources, such bone marrow (BM) peripheral blood samples, are suitable autologous We report here human BM-derived mesenchymal cells (MSCs). When...
5-Methylcytosine is found in both DNA and RNA; although its functions are well established, the exact role of 5-methylcytidine (m
Extracellular adenosine (ADO), present in high concentrations the tumor microenvironment (TME), suppresses immune function via inhibition of T cell and NK activation. Intratumoral generation ADO depends on sequential catabolism ATP by two ecto-nucleotidases, CD39 (ATP → AMP) CD73 (AMP ADO). Inhibition eliminates a major pathway production TME can reverse ADO-mediated suppression. Extensive interrogation structure–activity relationships (SARs), structure-based drug design, optimization...
The K-feldspar mineral is an insoluble potassium resource with a high content and the most extensive abundant reserves. To address insufficient supply of soluble fertilizers in China, application appropriate processing methods to extract from transform it into fertilizer great significance. date, various techniques have been developed produce fertilizer. This review summarizes main methods, i.e., hydrothermal, high-temperature pyrolysis, microbial decomposition, low-temperature for...
In this retrospective study conducted at Sichuan Jinxin Xinan Women and Children's Hospital spanning January 2015 to December 2021, our objective was investigate the impact of embryo cryopreservation duration on outcomes in frozen transfer. Participants, totaling 47,006 cycles, were classified into 3 groups based duration: ≤1 year (Group 1), 1 6 years 2), ≥6 3). Employing various statistical analyses, including 1-way ANOVA, Kruskal-Wallis test, chi-square a generalized estimating equation...
DDB2 exhibits a high affinity toward UV-damaged DNA, and it is involved in the initial steps of global genome nucleotide excision repair. Mutations gene cause genetic complementation group E xeroderma pigmentosum, an autosomal recessive disease manifested clinically by hypersensitivity to sunlight exposure increased predisposition skin cancer. Here we found that, human cells, initiating methionine residue was removed that N-terminal alanine could be methylated on its α-amino with...
The rising interest in understanding the functions, regulation, and maintenance of epitranscriptome calls for robust accurate analytical methods identification quantification post-transcriptionally modified nucleosides RNA. Monomethylations cytidine adenosine are common post-transcriptional modifications Herein, we developed an LC–MS/MS/MS coupled with stable isotope-dilution method sensitive quantifications 5-methylcytidine (m5C), 2′-O-methylcytidine (Cm), N6-methyladenosine (m6A),...
Antimony selenide is a promising abundant absorber material for solar cells. However, current Sb2Se3 photovoltaic devices, which are fabricated via thermal evaporation, tend to have stoichiometric problems and show suboptimal performance. In this paper, we use modified evaporator fabricate high-quality films. By dedicatedly cooling the substrate, can improve both morphology Sb2Se3/CdS heterojunction interface substantially. We find suitable annealing atmosphere, H2S, largely compensate...
The purpose of this study is to investigate the role high mobility group protein B1 (HMGB1) in placental development and fetal growth.
Can exposure to palmitic acid (PA), a common saturated fatty acid, modulate autophagy in both human and mouse trophoblast cells through the regulation of acyl-coenzyme A-binding protein (ACBP)?