A5101933765- Probiotics and Fermented Foods
- Ecology and Vegetation Dynamics Studies
- HIV/AIDS Research and Interventions
- Bacterial Genetics and Biotechnology
- Plant Ecology and Soil Science
- Forest, Soil, and Plant Ecology in China
- Tree-ring climate responses
- HIV Research and Treatment
- Insect-Plant Interactions and Control
- Protein Hydrolysis and Bioactive Peptides
- Ideological and Political Education
- Plant and animal studies
- HIV/AIDS drug development and treatment
- Hormonal and reproductive studies
- Cancer, Hypoxia, and Metabolism
- Plant Water Relations and Carbon Dynamics
- Plant Parasitism and Resistance
- HIV, Drug Use, Sexual Risk
- Metabolomics and Mass Spectrometry Studies
- Species Distribution and Climate Change
- Botany and Plant Ecology Studies
- Plant and Fungal Species Descriptions
- Forest Insect Ecology and Management
- Genomics and Phylogenetic Studies
- Drug Transport and Resistance Mechanisms
Peking University
2011-2025
Peking University Cancer Hospital
2011-2025
Inner Mongolia Medical University
2025
Fudan University
2019-2025
Pomona College
2009-2024
Shanxi Province Hospital of Traditional Chinese Medicine
2013-2024
State Key Laboratory of Medical Neurobiology
2019-2024
Abbott (United States)
2020-2024
Abbott Fund
2024
Abbott (United Kingdom)
2019-2024
See also the Commentary by Midgley
Anxiety and depression are frequently observed in patients suffering from trigeminal neuralgia (TN), but neural circuits mechanisms underlying this association poorly understood. Here, we identified a dedicated circuit the ventral hippocampus (vHPC) to medial prefrontal cortex (mPFC) that mediates TN-related anxiodepression. We found TN caused an increase excitatory synaptic transmission vHPC CaMK2A neurons mPFC inhibitory marked by expression of corticotropin-releasing hormone (CRH)....
Adherence challenges with oral tenofovir-based pre-exposure prophylaxis (PrEP) are common. We developed a point-of-care assay to objectively assess tenofovir in urine and conducted pilot trial examining the impact of counselling informed by use this on long-term PrEP adherence. This randomised enrolled women not serodiscordant partnerships 3 months after initiation at Kenya Medical Research Institute compare standard-of-care adherence versus (urine-test group) every for 12 months. In...
Bifidobacteria are natural inhabitants of the human gastrointestinal tract and well known for their health-promoting effects. Tolerance to bile stress is crucial bifidobacteria survive in colon exert beneficial actions. In this work, RNA-Seq transcriptomic analysis complemented with proteomic was used investigate cellular response Bifidobacterium longum BBMN68. The transcript levels 236 genes were significantly changed (≥ threefold, p < 0.001) 44 proteins differentially abundant (≥1.6-fold,...
Current pharmacologic adherence monitoring for antiretrovirals involves expensive, labor-intensive liquid chromatography/tandem mass spectrometry (LC-MS/MS)-based methods. Antibody-based assays can monitor and support in real time. We developed a tenofovir (TFV)-based immunoassay further validated it directly observed therapy (DOT) study.
Objective: HIV prevention and treatment studies demonstrate that pharmacologic adherence metrics are more accurate than self-report. Currently available use liquid-chromatography/tandem-mass-spectrometry (LC-MS/MS), which is expensive laboratory-based. We developed a specific sensitive antibody against tenofovir, the backbone of prevention, but conversion to lateral flow assay (LFA) – analogous urine pregnancy test required for point-of-care testing. describe development first LFA measure...
To overcome the deleterious effects of acid stress, Lactobacillus delbrueckii subsp. bulgaricus (L. bulgaricus) elicits an adaptive response to stress. In this study, proteomics approach complemented by transcriptional analysis revealed some cellular changes in L. CAUH1 during adaptation. We observed increase glycolysis-associated proteins, promoting optimal utilization carbohydrates. Also, rerouting pyruvate metabolism fatty biosynthesis was observed, indicating a possible modification cell...
Objective This prospective study was designed to investigate the relationship between lipids levels in both serum and seminal plasma semen parameters. Methods 631 subfertile men were enrolled. Their obesity-associated markers measured, parameters analyzed. Also, TC, TG, HDL LDL FFA, FSH, LH, total testosterone (TT), estradiol (E2) SHBG detected. Results Seminal TC positively related age. Serum TG (P < 0.001), while only them 0.05). For plasma, level had slightly positive correlation (r =...
ABSTRACT Aim To understand the scenarios of ‘anthropogenic biomes’ that integrate human and ecological systems, we need to explore impacts climate disturbance on vegetation in past present. Interactions among surface pollen, modern activities along land‐use gradients are tested evaluate natural anthropogenic forces shaping vegetation, hence aid reconstruction past. This turn will help with future predictions. Location The North‐east China Transect (NECT) north‐eastern China. Methods We...
We examined the relationship between urine tenofovir (TFV) levels measured with a novel immunoassay, which permits point-of-care testing, HIV seroconversion and objective adherence metrics in large preexposure prophylaxis (PrEP) demonstration project.
Highlights•STING-induced PD-L1hi Tu.Mons dominate the resistance to STING agonist therapy•Cell-intrinsic PD-L1 induced by STING-IFN-I axis drives protumoral Tu.Mons•TLR2 activation rewires signaling reduce cell-intrinsic PD-L1•STING combined with TLR2 pre-activation shows enhanced antitumor efficacySummarySTING is an important DNA sensing machinery in initiating immune response, yet therapies targeting have shown poor outcomes clinical trials. Here, we reveal that induces tumor monocytes...
Heart failure (HF) is a principal cause of morbidity and mortality worldwide, affecting an estimated 38 million people. Although significant progress has been made with respect to the underlying molecular mechanisms, role competing endogenous RNA (ceRNA) network in pathogenesis HF remains largely unknown. In this study, HF‑associated ceRNA was constructed based on differentially expressed long noncoding RNAs (lncRNAs), microRNAs (miRNAs) mRNAs obtained, respectively, from GSE77399, GSE104150...
Tolerance to bile stress is crucial for Lactobacillus paracasei survive in the intestinal tract and exert beneficial actions. In this work, global transcriptomic analysis revealed that 104 genes were significantly changed (log2FoldChange > 1.5, P < 0.05) detected transcripts of L. L9 when exposed 0.13% Ox-bile. The different expressed involved various biological processes, including carbon source utilization, amino acids peptide metabolism transmembrane transport, transcription factors,...
The drought tolerance and capacity to recover after are important for plant growth yield. In this study, two maize lines with different resistance were used investigate the effects of durations subsequent re-watering on photosynthetic capacity, electron transfer energy distribution, antioxidative defense mechanisms maize. Under short drought, plants decreased stomatal conductance transport rate, increased NPQ (Non-photochemical quenching) dissipate excess excitation in time protect...
Myocardial ischemia/reperfusion (I/R) injury is associated with the poor outcome and higher mortality after myocardial infarction. Recent studies have revealed that miR-199a-5p participates in process of I/R injury, but precise roles molecular mechanisms remain not well-studied. Ferroptosis has been proposed to promote cardiomyocyte death, closely injury. Herein, present study aimed explore function by which regulates whether contributes ferroptosis-induced death responding oxygen-glucose...