A5100454206- Pituitary Gland Disorders and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Adrenal and Paraganglionic Tumors
- Parkinson's Disease Mechanisms and Treatments
- Meningioma and schwannoma management
- Tuberous Sclerosis Complex Research
- CNS Lymphoma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Acute Ischemic Stroke Management
- Myasthenia Gravis and Thymoma
- Histiocytic Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Cancer, Hypoxia, and Metabolism
- Medical Imaging and Pathology Studies
- Amyotrophic Lateral Sclerosis Research
- Cerebral Venous Sinus Thrombosis
- Autoimmune Neurological Disorders and Treatments
- Neuroendocrine Tumor Research Advances
Huashan Hospital
2025
Fudan University
2025
Tianjin Medical University General Hospital
2025
Qingzhou City People's Hospital
2024
Capital Medical University
2010-2024
First Affiliated Hospital of Kunming Medical University
2022-2024
Kunming Medical University
2022-2024
First People's Hospital of Yunnan Province
2021-2024
Kunming University of Science and Technology
2024
Peking Union Medical College Hospital
2020-2023
Despite the successful use of a ketogenic diet in pediatric epilepsy, its application adults has been limited. The aim this meta-analysis was to summarize findings relevant published studies order identify efficacy and compliance with main subtypes (i.e., classic modified Atkins diet) intractable provide useful information for clinical practice.Electronic searches PubMed, EMBASE, Google Scholar, ISI Web Science were conducted patient epilepsy; included reviewed. Meta-analyses performed using...
Objective: Currently [18 F]FDDNP is the only PET imaging probe with ability to visualize hyperphosphorylated tau fibrillar aggregates in living subjects. In this work, we evaluate vivo labeling of brain neuropathology, primarily ta
Mutations in the parkin gene are currently thought to be most common cause of recessive familial Parkinsonism. Parkin functions as an E3 ligase regulate protein turnover, and its function mitochondrial quality control has been reported recently. Overexpression found prevent neuronal degeneration under various conditions both vivo vitro. Here, we generated a transgenic mouse model which expression wild type was driven by neuron-specific enolase (NSE) promoter. We that young old mice exhibited...
Neutrophil extracellular traps (NETs) contribute to the creation of a coagulation state in various diseases. Currently, it is not clear whether NETs are present thrombi and plasma patients with cerebral venous sinus thrombosis (CVST). This study aimed investigate presence blood samples from CVST procoagulant activity (PCA) during progression CVST.Thrombi obtained undergoing thrombectomy were examined by immunochemistry using neutrophil elastase (NE), CD66b citrullinated histone H3(citH3)....
Highlights•STING-induced PD-L1hi Tu.Mons dominate the resistance to STING agonist therapy•Cell-intrinsic PD-L1 induced by STING-IFN-I axis drives protumoral Tu.Mons•TLR2 activation rewires signaling reduce cell-intrinsic PD-L1•STING combined with TLR2 pre-activation shows enhanced antitumor efficacySummarySTING is an important DNA sensing machinery in initiating immune response, yet therapies targeting have shown poor outcomes clinical trials. Here, we reveal that induces tumor monocytes...
The epidemiological and clinical characteristics of infective endocarditis (IE) in mainland China, particularly following the COVID-19 pandemic, remain insufficiently understood. This study aims to examine temporal trends, features, factors influencing in-hospital mortality IE northern China from 2019 2023. multicenter, retrospective included 961 patients diagnosed with between 2023 across hospitals Henan, Shandong, Tianjin. Data were collected on demographics, comorbidities, status,...
The present study investigates the differences in inflammatory agents alterations, immune function, and leukocyte differential count evaluation severe pneumonia of SARS-COV-2 patients with Yidu-toxicity blocking lung syndrome after recommended Chinese medicine prescription decoction. A total 40 yidu-toxicity syndrome, diagnosed as following latest national recommendations for diagnosis treatment caused by (the 5th edition), were recruited. They randomly divided into pure western therapy...
Cerebral small vessel disease (CSVD) is characterized by functional and structural changes in vessels. We aimed to elucidate the relationship between dynamic cerebral autoregulation (dCA) neuroimaging characteristics of CSVD.A case-control study was performed. blood flow velocity (CBFV) bilateral middle arteries spontaneous arterial pressure were simultaneously recorded. Transfer function analysis used calculate dCA parameters (phase, gain, rate recovery CBFV [RoRc]). Neuroimaging CSVD...
Neuroblastoma (NB) is the most common tumour in children younger than 5 years old and notable for highly heterogeneous. Our aim was to quantify intra-tumoural metabolic heterogeneity of primary lesions by using 18F-FDG PET/CT evaluate prognostic value NB patients. We retrospectively enrolled 38 pretreatment patients our study. images were reviewed analyzed 3D slicer software. The semi-quantitative parameters measured, including maximum standard uptake (SUVmax), volume (MTV), total lesion...
Spasticity and contracture are major sources of disability in people with neurological impairments that have been evaluated using various instruments: the Modified Ashworth Scale, tendon reflex scale, pendulum test, mechanical perturbations, passive joint range motion (ROM). These measures generally either convenient to use clinics but not quantitative or they difficult conveniently clinics. We developed a manual spasticity evaluator (MSE) evaluate spasticity/contracture quantitatively...
Abstract Aims The ubiquilin‐like protein ubiquilin 2 (UBQLN2) is associated with amyotrophic lateral sclerosis and frontotemporal degeneration (ALS/FTD). biological function of UBQLN2 has previously been shown to be related stress granules (SGs). In this study, we aimed clarify the regulatory relationship between SGs. Methods transfected UBQLN2‐WT or UBQLN2‐P497H plasmids into cell lines (HEK293T, HeLa), observed process SG dynamics by immunofluorescence. Meanwhile, immunoblot analyses...
Abstract Background 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces Parkinson’s disease (PD)-like neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) via its oxidized product, 1-methyl-4-phenylpyridinium (MPP+), which is transported by dopamine (DA) transporter into DA nerve terminals. receptor subtype 3 (D3 receptor) participates neurotransmitter transport, gene regulation system, physiological accommodation G protein-coupled superfamily...
Background Growth hormone (GH)/thyroid stimulating (TSH) cosecreting pituitary adenoma (PA) is an exceedingly rare kind of bihormonal neuroendocrine tumors (PitNETs). Its clinical characteristics have rarely been reported. Objectives This study aimed to summarize the and experience diagnosis treatment among patients with mixed GH/TSH PAs from a single center. Methods We retrospectively reviewed 2063 diagnosed GH-secreting admitted Peking Union Medical College Hospital between January 1 st ,...
Most clinically non-functioning pituitary tumour arise from gonadotroph cells. However, functional adenoma is rare. Here we report a female case who presented with menstrual disturbances, however further workup demonstrated microadenoma elevated FSH and oestradiol level. Transsphenoidal resection was performed the surgical histopathology confirmed adenoma. Postoperatively, improvement in both symptoms hormonal profile were observed. Interestingly, initially enlarged polycystic ovaries became...
Background Mesenchymal stem cells (MSCs) are safe and effective in treating myocardial infarction (MI) have broad application prospects. However, the heterogeneity of MSCs may affect their therapeutic effect on disease. We recently found that derived from different segments same umbilical cord (UC) showed significant difference expression genes related to heart development injury repair. therefore hypothesized those with high above more treat MI tested it this study. Methods were isolated 3...