A5026672460- Adipose Tissue and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Curcumin's Biomedical Applications
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Thyroid and Parathyroid Surgery
- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Circular RNAs in diseases
- Thyroid Disorders and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Mitochondrial Function and Pathology
- Sirtuins and Resveratrol in Medicine
- Natural Antidiabetic Agents Studies
- Bone health and osteoporosis research
- RNA modifications and cancer
- Metabolomics and Mass Spectrometry Studies
- Neuroendocrine Tumor Research Advances
- Gut microbiota and health
- Drug Transport and Resistance Mechanisms
- Genetic and phenotypic traits in livestock
- Bone Metabolism and Diseases
- Traditional Chinese Medicine Analysis
China-Japan Friendship Hospital
2024-2025
Chongqing Medical University
2024
Peking Union Medical College Hospital
2021-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2023
Peking University
2022
Peking University First Hospital
2022
Women's Hospital, School of Medicine, Zhejiang University
2022
National Health and Family Planning Commission
2022
Beijing University of Chinese Medicine
2014-2021
Beijing Tian Tan Hospital
2018-2021
Background/Aims: Obesity has become a major health concern with few effective medications. Cinnamaldehyde (CA) been reported to exhibit anti-diabetic and anti-inflammatory properties. However, whether CA shows anti-obesity activity remains unknown. Therefore, the present study aimed investigate potential effects of on mice fed high-fat diet (HFD) explore possible mechanisms involved. Methods: Male C57BL/6J an HFD for 12 weeks were supplemented (40 mg/kg/day) via gavage additional 8 weeks....
Thyroid nodule rupture (TNR) is a rare and severe complication after thermal ablation (TA), mostly from benign thyroid nodules (BTN).
Background: Previous reviews have compared percutaneous thermal ablation (PTA) and surgical resection (SR), but none thoroughly assessed lymphatic or metastatic recurrence. A multidimensional investigation is needed to evaluate PTA's efficacy safety in treating various solid cancers, with a focus on
Objective The present study aimed to analyze the relationship between incidence of complications and tumor size following thermal ablation benign thyroid nodules (BTNs).
To evaluate the efficacy and safety of thermal ablation (TA) for follicular thyroid neoplasms (FTN) ≤ 3 cm. This retrospective multicenter study enrolled 161 patients (131 females; mean age, 46 ± 15 years [range, 11-86]) who underwent TA FTN cm between January 2014 October 2023 from eight centers in China. The median follow-up time was 12 months (IQR, 12-24 months). Based on maximum diameter (MD) nodule, were divided into two groups: Group 1 (MD 2 cm) (2 < MD cm). Post-ablation assessments...
For females, menarche is a most significant physiological event. Age at (AAM) trait with high genetic determination and associated major complex diseases in women. However, specific genes for AAM variation are largely unknown. To identify factors underlying variation, genome-wide association study (GWAS) examining about 380,000 SNPs was conducted 477 Caucasian A follow-up replication performed to validate our GWAS findings using two independent cohorts 854 siblings 762 unrelated subjects,...
Recent genome-wide association (GWA) studies have identified a number of novel genes/variants predisposing to obesity. However, most GWA focused on individual single-nucleotide polymorphism (SNPs)/genes with strong statistical phenotypic trait without considering potential biological interplay the tested genes. In this study, we performed pathway-based analysis for BMI and body fat mass. We used level genotype data generated from 1,000 unrelated US whites that were genotyped ~500,000 SNPs....
Curcumin is an active component derived from Curcuma longa L. which a traditional Chinese medicine that widely used for treating metabolic diseases through regulating different molecular pathways. Here, in this study, we aimed to comprehensively investigate the effects of curcumin on glycolipid metabolism vivo and vitro then determine underlying mechanism. Male C57BL/6 J obese mice 3T3-L1 adipocytes were respectively. Our results demonstrated treatment with eight weeks decreased body weight,...
Abstract Circulating long non-coding RNAs (lncRNAs) serve as valuable biomarkers in a number of human diseases. However, lncRNA have yet to be identified obesity. We aim characterize circulating expression obese and non-obese subjects. First, we assessed the genome-wide profiles blood from 3 found significant decrease levels three lncRNAs (lncRNA-p5549, lncRNA-p21015 lncRNA-p19461) subjects only. Next, using RT-PCR measured these 33 similar differences. Moreover, negative correlation between...
Organic anion-transporting polypeptide (OATP) 1A2 has the potential to be a target for central nervous system drug delivery due its luminal localization at human blood-brain barrier and broad substrate specificity. We found OATP1A2 mRNA expression in brain comparable breast cancer resistance protein OATP2B1 much higher than P-glycoprotein (P-gp), confirmed greater relative other tissues. The goal of this study was establish model explore OATP1A2-mediated transcellular transport drugs...
Mitochondrial DNA (mtDNA) variants are involved in the pathogenesis of human complex diseases, especially for age-related disorders, including osteoporosis. However, role mtDNA osteoporosis is largely unknown. In this study, we performed a mitochondria-wide association study large sample 2286 unrelated Caucasian subjects. A total 445 mtSNPs were genotyped and 72 survived quality control. We first examined between bone mineral density (BMD), identified that an mtSNP, mt4823 within ND2 gene,...
OATP1A2 is expressed in the luminal membrane of human blood-brain barrier (BBB). The tissue with highest mRNA expression brain.We have established a robust BacMam2-OATP1A2 transduced HEK293 system. Among 36 central nervous system (CNS) marketed drugs tested, hydrophilic triptans, 5-HT1B/1D receptor agonists for treatment migraine attacks, were identified as substrates. Kinetics (Km and Vmax) determined six triptans.Structure-activity relationship (SAR) obtained from 18 triptan structural...
Jiang Tang Xiao Ke (JTXK) granule, a Chinese herbal formula, has been used clinically to treat type 2 diabetes (T2DM) for decades. Our previous studies showed that JTXK granule exhibited anti-diabetic and anti-oxidative functions in experimental diabetic rats induced by high fat diet streptozotocin. However, the underlying mechanisms remain poorly understood. Herein, we aimed investigate therapeutic effect of on T2DM KKAy mice possible associations with skeletal muscle current study. results...
Purpose: Mitochondrial dysfunction in adipose tissue has emerged as key to the development of obesity and diabetes. Salvianolic acid B (SalB) is a water-soluble ingredient derived from Salvia miltiorrhiza that been shown possess potential anti-obese anti-diabetic activities. However, cellular mechanism SalB on mitochondrial function with respect these metabolic disorders not elucidated. Therefore, we aim investigate effects 3T3-L1 adipocytes analyze underlying molecular mechanism. Methods:...
Accumulating evidence suggests that mitochondrial dysfunction and adipocyte differentiation promote lipid accumulation in the development of obesity diabetes. Curcumin is an active ingredient extracted from Curcuma longa has been shown to exhibit antioxidant anti-inflammatory potency metabolic disorders. However, underlying mechanisms curcumin adipocytes remain largely unexplored. We studied effects on adipogenic oxygen consumption analysed possible mechanisms. 3T3-L1 preadipocytes were used...
Mitochondria play a central role in ATP production and energy metabolism. Previous studies suggest that common variants mtDNA are associated with several complex diseases, including obesity. To test the hypothesis influence obesity-related phenotypes, BMI body fat mass, we genotyped total of 445 mtSNPs across whole mitochondrial genome large sample 2,286 unrelated Caucasian subjects. 72 these passed quality control criteria, were used for subsequent analyses. We also classified all subjects...
Long non-coding RNAs (lncRNAs) play an important role in epigenetic regulation, and abnormalities may lead to male infertility. To investigate whether lncRNAs are involved intergenerational inheritance of obesity obesity-induced decline fertility, we divided mice into (F0 fed a high-fat diet, F0-HFD) non-obese normal chow, F0-NC) model groups their offspring (F1-HFD F1-NC, respectively). We examined the differences expression levels mRNAs F0-HFD/F0-NC F1-HFD/F1-NC groups. The results...