A5072824384- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Genetic Associations and Epidemiology
- Cancer-related molecular mechanisms research
- Bone health and treatments
- RNA modifications and cancer
- RNA Research and Splicing
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Cytokine Signaling Pathways and Interactions
- Growth Hormone and Insulin-like Growth Factors
- Nutrition and Health in Aging
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Body Composition Measurement Techniques
- Genomic variations and chromosomal abnormalities
- Bioinformatics and Genomic Networks
- Genetic and phenotypic traits in livestock
- Adipose Tissue and Metabolism
- Biomarkers in Disease Mechanisms
- TGF-β signaling in diseases
- Galectins and Cancer Biology
- T-cell and B-cell Immunology
- interferon and immune responses
- Diabetes and associated disorders
Wuhan Institute of Virology
2024-2025
Chinese Academy of Sciences
2025
Soochow University
2016-2025
Chengdu University of Traditional Chinese Medicine
2024-2025
Gansu Provincial Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Xiangya Hospital Central South University
2024-2025
Central South University
2024-2025
State Key Laboratory of Virology
2024
Wuhan University
2019-2024
A key assumption in studying mRNA expression is that it informative the prediction of protein expression. However, only limited studies have explored mRNA-protein correlation yeast or human tissues and results been relatively inconsistent. We carried out analyses on expressions freshly isolated circulating monocytes from 30 unrelated women. The expressed proteins for 71 genes were quantified identified by 2-D electrophoresis coupled with mass spectrometry. corresponding Affymetrix gene...
To identify novel DNA methylation sites significant for rheumatoid arthritis (RA) and comprehensively understand their underlying pathological mechanism.We performed (1) genome-wide mRNA expression profiling in peripheral blood mononuclear cells from RA patients health controls; (2) correlation analysis causal inference tests data; (3) differential genes regulatory network construction; (4) validation of 10 positions (DMPs) interest corresponding gene expressions; (5) between PARP9 its level...
Abstract Rheumatoid arthritis (RA) is an autoimmune disease characterized by infiltration of immune cells in the synovium. However, crosstalk and synovial fibroblasts still largely unknown. Here, global miRNA screening plasma exosomes was carried out with a custom microarray (RA patients vs. healthy controls = 9:9). A total 14 exosomal miRNAs were abnormally expressed RA patients. Then, downregulated expression miR-204-5p confirmed both replication 30:30) validation groups 56:60). Similar to...
Doxorubicin is a commonly used anthracycline chemotherapeutic agent; however, its application limited owing to cardiotoxicity. Current clinical treatments cannot efficiently or fully prevent doxorubicin-induced toxicity, primarily because pathogenesis and mechanisms of action remain unknown. In this study, we established rat model chronic cardiotoxicity, in which the severity cardiac fibrosis hydroxyproline levels increased time-dependent manner. damaged mitochondria blood vessels induced...
The galectin 3 binding protein (LGALS3BP, also known as 90K) is a ubiquitous multifunctional secreted glycoprotein originally identified in cancer progression. It remains unclear how 90K functions innate immunity during viral infections. In this study, we found that infections resulted elevated levels of 90K. Further studies demonstrated expression suppressed virus replication by inducing IFN and pro-inflammatory cytokine production. Upon investigating the mechanisms behind event,...
Recent evidence has gradually recognized that the immune and skeletal systems are two closely correlated systems, but specific factors on bone mineral density (BMD) largely unknown. Based summary-level data of genome-wide association studies (GWASs), we performed a series analyses including two-sample Mendelian randomization (MR) analysis to test potential causal links between 731 traits [including median fluorescence intensities (MFIs), absolute cell (AC) counts, relative (RC) morphological...
Abstract Background This study aimed to investigate the association of high-sensitivity C-reactive protein (hs-CRP) with incident frailty as well its effects on pre-frailty progression and regression among middle-aged older adults. Methods Based index (FI) calculated 41 items, 6890 eligible participants without at baseline from China Health Retirement Longitudinal Study (CHARLS) were categorized into health, pre-frailty, groups. Logistic models used estimate longitudinal between hs-CRP...
Low bone mineral density (BMD) is a risk factor of osteoporosis and has strong genetic determination. Genes influencing BMD fundamental mechanisms leading to have yet be fully determined. Peripheral blood monocytes (PBM) are potential osteoclast precursors, which could access resorption surfaces differentiate into osteoclasts resorb bone. Herein, we attempted identify susceptibility gene(s) characterize their function(s), through an initial proteomics discovery study on PBM in vivo,...
Menopause is one of the crucial physiological events during life a woman. Transition menopause status accompanied by increased risks various health problems such as osteoporosis. Peripheral blood monocytes can differentiate into osteoclasts and produce cytokines important for osteoclast activity. With quantitative proteomics LC-nano-ESI-MS(E) (where MS(E) elevated-energy MS), we performed protein expression profiling peripheral in 42 postmenopausal women with discordant bone mineral density...
Radiation-induced dermatitis is a serious side effect of radiotherapy, and very few effective treatments are currently available for this condition. We previously demonstrated that apoptosis an important feature radiation-induced adipose-derived stem cells (ADSCs) one the most promising types have protective on acute dermatitis. Cathepsin F (CTSF) recently discovered protein plays role in apoptosis. In study, we investigated whether ADSCs affect chronic dermatitis, underlying mechanisms...
For females, menarche is a most significant physiological event. Age at (AAM) trait with high genetic determination and associated major complex diseases in women. However, specific genes for AAM variation are largely unknown. To identify factors underlying variation, genome-wide association study (GWAS) examining about 380,000 SNPs was conducted 477 Caucasian A follow-up replication performed to validate our GWAS findings using two independent cohorts 854 siblings 762 unrelated subjects,...
Osteoporosis is characterized mainly by low bone mineral density (BMD). Many cytokines and chemokines have been related with metabolism. Monocytes in the immune system are important sources of for However, no study has investigated vivo expression a large number various factors simultaneously human monocytes underlying osteoporosis. This explored pattern general cytokines, chemokines, their receptor genes validated significant qRT-PCR genetic association analyses. Expression profilings were...
Rheumatoid arthritis (RA) is a complex autoimmune disease. Using gene-based association research strategy, the present study aims to detect unknown susceptibility RA and address ethnic differences in genetic between European Asian populations. Gene-based analyses were performed with KGG 2.5 by using publicly available large datasets (14,361 cases 43,923 controls of subjects, 4,873 17,642 Subjects). For newly identified RA-associated genes, gene set enrichment protein-protein interactions...
Abstract Aptamers, as a kind of small-molecule nucleic acid, have attracted much attention since their discovery. Compared with biological reagents such antibodies, aptamers the advantages small molecular weight, low immunogenicity, cost, and easy modification. At present, are mainly used in disease biomarker discovery, diagnosis, treatment, targeted drug delivery vectors. In process screening optimizing aptamers, it is found that there still many problems need to be solved design library,...
Crimean-Congo hemorrhagic fever is a tick-borne zoonotic disease that may be severe and present in many African countries. We aimed to understand the seroprevalence risk for virus Tanzania by testing archived serum samples from patients enrolled prospective cohort study.
To investigate the relationship between obstructive sleep apnea hypopnea syndrome (OSAHS) severity and fat, bone, muscle indices. This study included 102 patients with OSAHS retrospectively reviewed their physical examination data. All underwent polysomnography, body composition analysis, dual-energy X-ray absorptiometry, computed tomography (CT) blood test. Correlation multiple linear regression analyses were performed using SPSS 22.0. Among fat indices, mass (FM) (r = 0.27-0.43),...
To evaluate the efficacy and safety of esketamine-based patient-controlled intravenous analgesia following total hip arthroplasty. A 135 arthroplasty patients were randomly assigned to one three treatment groups: esketamine, sufentanil or continuous fascia iliaca compartment block (FICB) group. The primary endpoint was postoperative visual analogue scale (VAS) pain scores at rest on movement. Secondary endpoints included preoperative 1-day 7-day Self-Rating Anxiety Scale (SAS) Depression...
Abstract Encephalomyocarditis virus (EMCV), a potential zoonotic pathogen, poses significant socioeconomic and public health challenges across various host species. Although EMCV rarely triggers severe clinical symptoms in humans, its widespread prevalence unique biological characteristics underscore the need for continuous surveillance development of effective therapeutics prophylactics. In this study, we evaluated neutralizing effects monoclonal antibody derived from spleens mice immunized...
Polygala tenuifolia Willd. (PT) is commonly used to address cognitive impairment (CI), while Magnolia officinalis Rehd. et Wils (MO) often prescribed for gastrointestinal issues as well CI. This study seeks explore the impacts and mechanisms behind combined therapy of PT MO (PM) in treating CI, based on concept gut-brain axis. The characteristic components PT, MO, PM were identified using ultra-high performance liquid chromatography-tandem triple quadrupole mass Spectrometry (UPLC-MS/MS). A...
Glucosamine is a widely used supplement for treating osteoarthritis and joint pain. New evidence suggests potential association between glucosamine type 2 diabetes, inflammation cardiometabolic risk. We aimed to prospectively evaluate the of habitual use with risk diabetic microvascular complications based on data from large-scale nationwide prospective UK Biobank cohort study. This analysis included 21,171 participants diabetes who were free Biobank. Incidence was ascertained via electronic...
Abstract Background The immune system likely plays a role in the pathogenesis of spinocerebellar ataxia type 3 (SCA3). Peripheral blood leukocytes are indicative status neurodegenerative diseases. However, alterations characteristics peripheral at different stages SCA3 and their potential roles disease progression remain unclear. Objectives goal was to identify leukocyte profiles analyze correlation with severity. Methods This cross‐sectional study included 150 total ATXN3 expansion carriers...