A5101569228- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Phytochemicals and Antioxidant Activities
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Alcohol Consumption and Health Effects
- Autophagy in Disease and Therapy
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Ubiquitin and proteasome pathways
- Neuroendocrine Tumor Research Advances
- Circadian rhythm and melatonin
- Metabolism and Genetic Disorders
Shanghai Medical College of Fudan University
2020-2025
Fudan University Shanghai Cancer Center
2020-2025
Nanjing Medical University
2013-2025
Nantong University
2023-2025
Shanghai Clinical Research Center
2022-2025
Affiliated Hospital of Nantong University
2023-2025
Beijing Sport University
2022-2025
Shandong University
2021-2024
Sichuan University
2021-2024
West China Hospital of Sichuan University
2021-2024
Blood-based protein biomarkers have recently shown as simpler diagnostic modalities for colorectal cancer, while their association with clinical pathological characteristics is largely unknown. In this study, we not only examined the sensitivity and reliability of single/multiple serum markers diagnosis, but also assessed connection parameters from a total 279 cancer patients. Our study that glycoprotein carcinoembryonic antigen (CEA) owns highest among single marker in order CEA > 72-4...
Abstract Mounting evidence demonstrates that long non-coding RNAs (lncRNAs) are novel transcripts governing multiple biological processes, and their dysregulation is involved in the development progression of types cancers. Small Nucleolar RNA Host Gene 20 (SNHG20) a 2183 bp lncRNA, its overexpression predicts poor prognosis colorectal cancer hepatocellular carcinoma. However, clinical relevance SNHG20 molecular mechanisms affecting cell phenotype have not been documented. Here, we found was...
Abstract Doxorubicin is conventionally used in chemotherapy against hepatocellular carcinoma (HCC), but acquired resistance developed during long-term therapy limits its benefits. Autophagy, a conserved catabolic process for cellular self-protection and adaptation to the changing environment, regarded as potential clinical target overcome doxorubicin resistance. In this study, role of miR-223 modulating doxorubicin-induced autophagy sensitivity were evaluated four transfected human HCC cell...
// Yue Zhou 1,* , Chao Liang Fei Xue 2,* Wei Chen 1 Xiao Zhi Xinhua Feng 3 Xueli Bai and Tingbo Department of Hepatobiliary Pancreatic Surgery, The Second Affiliated Hospital, School Medicine, Zhejiang University, Hangzhou, PR China 2 People's Hospital Zhengzhou Zhengzhou, Life Sciences Institute Innovation Center for Cell Signaling Network, * These authors contributed equally to this work Correspondence to: Liang, email: Bai, Keywords : hepatocellular carcinoma, salinomycin, doxorubicin,...
The Thelephora ganbajun mushroom has been found to be a potential rich source of natural antioxidants. In this study, an ultrasound-assisted extraction (UAE) technique together with GRAS (generally recognized as safe) solvents (ethanol and water) was used maximize the antioxidants from ganbajun. Five parameters concentration, solvent solid ratio, time, temperature ultrasound power) were investigated by single-factor experiments, then central composite rotatable design employed study...
Pancreatic ductal adenocarcinoma (PDAC) is a destructive cancer with poor prognosis. Both novel therapeutic targets and approaches are needed to improve the overall survival of PDAC patients. MicroRNA-212 (miR-212) has been reported as tumor suppressor in multiple cancers, but its definitive role exact mechanism progression pancreatic unclear. In this study, we developed new chimeric peptide (PL-1) composed plectin-1-targeted PDAC-specific arginine-rich RNA-binding motifs which could...
Radiation-induced lung injury (RILI) is a prevalent complication of thoracic radiotherapy in cancer patients. A comprehensive understanding the underlying mechanisms RILI essential for development effective prevention and treatment strategies.To investigate RILI, we utilized mouse model that received 12.5 Gy whole-thoracic irradiation. The evaluation was performed using combination quantitative real-time polymerase chain reaction (qRT-PCR), enzyme-linked immunosorbent assay (ELISA),...
The fruit of Melastoma sanguineum Sims is an edible and sweet wild fruit. In our previous study, the was found to have a strong antioxidant property. this ultrasound-assisted extraction (UAE) method developed extract natural antioxidants from Sims, response surface methodology used optimize conditions UAE maximize efficiency. influence five independent parameters (ethanol concentration, solvent/material ratio, extracting time, temperature, ultrasound power) on efficiency were investigated...
Evidence is required to evaluate the effectiveness of population-level endoscopic screening for esophageal cancer (EC). In this study, 5,632 permanent residents aged 25-65 years from 6 villages in Hua County, Henan Province, China, were defined as cohort and offered intensive screening. Residents all 914 remaining County included control cohort, age-sex standardization was used calculate expected numbers EC upper gastrointestinal (GI) tract cases deaths cohort. The assessed by comparing...
Osimertinib, as a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), showed more potent efficacy against brain metastasis (BM) in untreated EGFR-mutant nonsmall cell lung cancer (NSCLC) the FLAURA study. However, overall survival (OS) benefit of osimertinib and clinical value cranial local therapy (CLT) these patients remain undetermined. Here we conducted retrospective study involving NSCLC with BMs receiving first-line or first-generation EGFR-TKIs....