A5102418084- Esophageal Cancer Research and Treatment
- Cervical Cancer and HPV Research
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Hepatitis B Virus Studies
- Genital Health and Disease
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Global Cancer Incidence and Screening
- Head and Neck Cancer Studies
- Reproductive tract infections research
- Helicobacter pylori-related gastroenterology studies
- Health Systems, Economic Evaluations, Quality of Life
- Genetic factors in colorectal cancer
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Research Studies
- Healthcare Systems and Reforms
- Gastroesophageal reflux and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Extracellular vesicles in disease
Peking University Cancer Hospital
2016-2025
Peking University
2016-2025
Harbin Institute of Technology
2024
State Key Laboratory of Molecular Oncology
2023-2024
Changhai Hospital
2019-2022
Second Military Medical University
2019-2022
Qingdao University
2021-2022
Affiliated Hospital of Qingdao University
2021-2022
Xi’an Jiaotong-Liverpool University
2022
Anyang Tumor Hospital
2012-2018
Objective Description of the design and preliminary results baseline recruitment screening in endoscopic for esophageal cancer China (ESECC), first randomised controlled trial (RCT) assessing efficacy cost-effectiveness squamous cell carcinoma (ESCC). Design ESECC is a cluster RCT, 668 villages rural Hua County, Henan Province, high-incidence area ESCC China, were into two arms at ratio 1:1. Screening arm participants screened by Lugol chromoendoscopy; no was performed control arm....
To evaluate the effectiveness of endoscopic screening against incidence and mortality from esophageal squamous cell carcinoma (ESCC).
Abstract Background: The risk factors for esophageal squamous cell carcinoma (ESCC) in the high-incidence areas of China remain unclear. Methods: A total 300 patients with ESCC and 900 controls matched age sex were enrolled Anyang (China), a high-risk area China. In tumor tissue cases biopsies controls, presence human papillomavirus (HPV) DNA was assessed by an SPF1/GP6+-mediated PCR followed sequencing. serum antibody against HPV-16 E7 oncoprotein use ELISA. ORs 95% confidence intervals...
Abstract Background About 25–37% of resectable pancreatic ductal adenocarcinoma (PDAC) had a great chance early recurrence after radical resection, which is mainly due to preoperative micrometastasis. We herein demonstrated the profiles ctDNA in PDAC and use identify patients with potential Methods A total 113 44 PDACs were enrolled discovery validation cohorts, separately. panel containing 50 genes was used screen by an NGS-based assessment high specificity. Results In cohort, overall...
Oesophageal squamous cell carcinoma (ESCC) has a generally poor prognosis, due to the lack of effective treatment methods. Immunotherapeutic approaches based on tumour-infiltrating lymphocytes (TILs) have demonstrated that durable responses are produced in some patients with solid tumours, which suggests potential feasibility clinical application immunotherapy for ESCC. However, many basic characteristics TILs ESCC poorly understood, including clonality, specificity and spatial heterogeneity...
Cervical microbiota composition is associated with cervical HPV infection and CIN severity. Previous studies only assessed the total association between infections or CINs, yet no study reported direct indirect associations CINs mediated by infection, respectively. The aim of this was to investigate microbiotas 126 women 1- (normal cytology 1) 40 2+ (CIN 2 3) were analyzed using Illumina sequencing based on 16S rRNA gene. detected a highly sensitive PCR primer set (SPF1/GP6+). Indirect...
Evidence is required to evaluate the effectiveness of population-level endoscopic screening for esophageal cancer (EC). In this study, 5,632 permanent residents aged 25-65 years from 6 villages in Hua County, Henan Province, China, were defined as cohort and offered intensive screening. Residents all 914 remaining County included control cohort, age-sex standardization was used calculate expected numbers EC upper gastrointestinal (GI) tract cases deaths cohort. The assessed by comparing...
Human papillomavirus (HPV) types 16, 18 and 58 are ranked the top three high-risk HPV for cervical intraepithelial neoplasia (CIN) invasive carcinoma. We aimed to evaluate diversity of HPV16, HPV18, HPV58 genetic variants by capture technology combined with next generation sequencing. 295, 73, 148 variations were observed in 51 7 11 genomes, respectively. HPV16 isolates predominantly A variant lineage, sublineage A4 (Asian) was most common. However, there no significant differences...
We aimed to establish a Medical-Insurance-System-based Cancer Surveillance System (MIS-CASS) in China and evaluate the completeness timeliness of this system through reporting cancer incidence rates using claims data two regions northern southern China.We extracted from medical insurance systems Hua County Henan Province, Shantou City Guangdong Province Jan 1, 2012 Jun 30, 2019. These have been considered be high risk for oesophageal cancer. developed rigorous procedure MIS-CASS, which...
Abstract Background:Esophageal squamous cell carcinoma (ESCC) exhibits a long latency period and has significant geographical disparity in incidence, which underscores the need for models predicting long-term absolute risk adaptable to regional disease burden. Methods:31,883 participants large-scale population-based screening trial (Hua County, China) were enrolled develop model. Severe dysplasia above (SDA) identified at or follow-up defined as outcome. We calculated three steps: 1)...
Introduction: Image-based diagnostic tools that aid endoscopists to biopsy putative esophageal malignant lesions are essential for ensuring the standardization and quality of Lugol’s chromoendoscopy. But there's no such model available yet. Methods: We developed a using endoscopic Lugol-unstained (LULs) features baseline data from 1099 individuals enrolled large-scale population-based ESCC screening cohort. 603 participants clinical outpatient cohort were included as external validation set....
We previously found that HPV16 E6 causes the degradation of tumor suppressor protein TSC2, resulting in phosphorylation S6 kinase and even absence insulin. In present study, we investigated role E6‐associated (E6AP) E6‐induced TSC2 degradation. Our results demonstrated was targeted for presence or E6. Over‐expression E6AP enhanced by E6, while expression a dominant negative (C833A) inhibited Additionally, using shRNAs to block positive cells, significantly prolonged half‐life. An vivo...
// Ying Liu 1, * , Wenjun Yang 2 Yaqi Pan 1 Jiafu Ji 3 Zheming Lu Ke Key Laboratory of Carcinogenesis and Translational Research (Ministry Education), Genetics, Peking University Cancer Hospital Institute, Haidian, Beijing, China Reproduction Heredity Ningxia Region, Medical Oncology Department General Hospital, University, Yinchuan, Ningxia, Gastrointestinal Surgery, These authors contributed equally to this work Correspondence to: Lu, e-mail: zheminglu@163.com Ke, keyang@bjmu.edu.cn...
Abstract Background: Despite the established link between oral human papillomavirus (HPV) infection and a subset of oropharyngeal squamous cell carcinoma (OSCC), little is known about epidemiology HPV among healthy adults in China. Methods: Oral swab specimens questionnaires were collected from 5,410 individuals (ages 25–65 years). DNA exfoliated cells was tested by general primer-mediated (SPF1/GP6+) PCR sequencing. Univariate multivariate analyses performed to assess associations exposure...
Background Despite the probably causal link between Merkel cell polyomavirus (MCPyV) infection and carcinoma (MCC), a rare but aggressive skin malignancy, little is known about seroepidemiology of MCPyV among healthy adults in China. Methods Serum antibodies against were evaluated by multiplex serology population-based study 5548 (including 1587 heterosexual couples) aged 25–65 years who enrolled from rural Anyang, China 2007–2009. Univariate multivariate logistic regression analyses...
Abstract HPV integration plays an important role in cervical carcinogenesis. genotypes and the exact sites were investigated using capture technology combined with next generation sequencing 166 women. Three, one six verified 7 HPV-positive ‘normal epithelium’, 6 CIN2 15 CIN 3 samples, respectively. Of 10 integrations, nine involved HPV33 HPV16, Our study accurately evaluated level CINs normal tissues high-throughput viral detection method providing basic evidence for integration-driven
Hysterectomy is one of the most common surgical procedures performed on women in developed countries; however, little known about epidemiology hysterectomy low-income to middle-income regions. This study seeks evaluate prevalence and its risk factors rural China.Questionnaires were collected from 3328 female adults aged 25â€"69 years Anyang, China, 2009â€"2011. status was ascertained by gynaecologist at time cytological test. Univariate multivariate regression analyses assess for...
Abstract Background Heterogeneity should be carefully addressed to facilitate establishment of effective population-level blood lipid management. The primary aim the study was investigate gender heterogeneity in prevalence dyslipidemia, including trends with age and associated factors middle rural Chinese. Methods This is a cross-sectional based on baseline investigation population-based randomized controlled trial China, involving 26,378 permanent residents 45–69. age-specific dyslipidemia...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) has the lowest overall survival rate primarily due to late onset of symptoms and rapid progression. Reliable accurate tests for early detection are lacking. We aimed develop a noninvasive test PDAC by capturing circulating tumour DNA (ctDNA) methylation signature in blood. Methods Genome-wide profiles were generated from nonmalignant tissues plasma. Methylation haplotype blocks (MHBs) examined discover de novo markers. They combined...
Background Human papillomavirus (HPV) has been observed repeatedly in esophageal squamous cell carcinoma (ESCC) tissues. However, the causal relationship between HPV infection and onset of ESCC remains unknown. A large cohort study focusing on this topic is being carried out rural Anyang, China. Methodology/Principal Findings The Anyang Esophageal Cancer Cohort Study (AECCS) a population-based prospective endoscopic designed to investigate association ESCC. This paper provides information...
Human papillomavirus type 16 plays a critical role in the neoplastic transformation of cervical cancers. Molecular variants HPV16 existing different ethnic groups have shown substantial phenotypic differences pathogenicity, immunogenicity and tumorigenicity. In this study, we sequenced entire genome 76 isolates originated from Anyang, central China. Phylogenetic analysis these sequences identified two major Anyang area, namely European prototype (E(p)) Asian (E(As)). These show high degree...
HPV transmission dynamics have rarely been studied in the general population, especially China. We followed genital infection status of both partners 874 couples aged 25-65 years from rural China for up to 7 bi-annual visits during 2009-2013. The positive concordance and rate a couple were evaluated relevant risk factors assessed. any, oncogenic, non-oncogenic was 15.52%, 16.18% 10.41%, respectively. Male-to-female 7.11, 12.13 4.77/1000 person months oncogenic female-to-male 5.56, 2.37,...