A5102983703- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Renal cell carcinoma treatment
- Immune Cell Function and Interaction
- Neuroblastoma Research and Treatments
- RNA modifications and cancer
- Nanoparticle-Based Drug Delivery
- Immune cells in cancer
- Lanthanide and Transition Metal Complexes
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Research Studies
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
Second Military Medical University
2015-2025
Changhai Hospital
2014-2025
Affiliated Hospital of Southwest Medical University
2020-2024
Eastern Hepatobiliary Surgery Hospital
2014-2024
Tianjin Medical University Cancer Institute and Hospital
2020-2023
Chongqing University
2023
United States Department of the Navy
2023
Sichuan University
2015-2022
Southwest Medical University
2022
First Affiliated Hospital of Sichuan Medical University
2021
Despite the uniform mortality in pancreatic adenocarcinoma (PDAC), clinical disease heterogeneity exists with limited genomic differences. A highly aggressive tumor subtype termed 'basal-like' was identified to show worse outcomes and higher inflammatory responses. Here, we focus on microbial effect PDAC progression present a comprehensive analysis of microbiome different subtypes resectable tumors using metagenomic sequencing. We found distinctive communities basal-like an increasing...
Chromatin accessibility plays an essential role in controlling cellular identity and the therapeutic response of human cancers. However, chromatin landscape gene regulatory network pancreatic cancer are largely uncharacterized. Here, we integrate profiles 84 organoid lines with whole-genome sequencing data, transcriptomic data results drug sensitivity analysis 283 epigenetic-related chemicals 5 chemotherapeutic drugs. We identify distinct transcription factors that distinguish molecular...
Metabolic reprogramming is known as an emerging mechanism of chemotherapy resistance, but the metabolic signatures pancreatic ductal adenocarcinomas (PDACs) remain unclear. Here, we characterize metabolomic profile PDAC organoids and classify them into glucomet-PDAC (high glucose metabolism levels) lipomet-PDAC lipid levels). Glucomet-PDACs are more resistant to than lipomet-PDACs, patients with have a worse prognosis. Integrated analyses reveal that GLUT1/aldolase B...
Abstract Background About 25–37% of resectable pancreatic ductal adenocarcinoma (PDAC) had a great chance early recurrence after radical resection, which is mainly due to preoperative micrometastasis. We herein demonstrated the profiles ctDNA in PDAC and use identify patients with potential Methods A total 113 44 PDACs were enrolled discovery validation cohorts, separately. panel containing 50 genes was used screen by an NGS-based assessment high specificity. Results In cohort, overall...
A ROX and enzyme-responsive biodegradable gadolinium-based mCA was prepared, demonstrating a short gadolinium retention time sufficient MRI contrast efficacy in tumors.
During inflammation, inflammatory cells are rapidly recruited to sites of infection or injury, where they cross physiological barriers around the infected site and further infiltrate into tissues. Other cells, such as erythrocytes, endothelial stem also play prominent roles in host defense tissue repair. In recent years, nanotechnology has been exploited deliver drugs inflammation. For example, nanoparticles camouflaged with a cell membrane novel drug-delivery platform that can interact...
Perineural invasion and immunosuppressive tumor microenvironment are the distinct features of pancreatic ductal adenocarcinoma (PDAC). Heterogeneous myeloid-derived suppressor cells (MDSCs) potent suppressors antitumor immunity, posing obstacles for cancer immunotherapy. Increasing evidences have demonstrated accumulation MDSCs in PDAC patients. However, role perineural existence novel MDSC subsets during remain unclear. This study found that lymphocytic cuffs were frequently present chronic...
Typical methods for the analysis of mixture components include multiple linear regression, partial squares, and artificial neural network. However, these need large amount samples time to improve recognition accuracy. In this paper, based on data obtained from terahertz spectroscopy, an identification method with less sample requirements lower calculation but higher accuracy is proposed. Based wavelet transform, baseline elimination, support vector loop iteration samples, specific substance...
Interleukin (IL)-33 is a proinflammatory cytokine contributing to the pathogenesis of rheumatoid arthritis (RA). The gene encoding IL-33 may serve as genetic factor and be associated with risk RA. To investigate potential association between IL33 RA, we performed case-control study based on Chinese Han population.A three-stage was performed. Two tag single-nucleotide polymorphisms (SNPs) (rs7044343 rs10975514), mapping gene, were first genotyped in discovery population. We further rs7044343...
Herein, two water-soluble PROXYL-based magnetic resonance imaging (MRI) macromolecular organic contrast agents (mORCAs) are designed and synthesized: linear cross-linked PCE-mPEG-Ppa-PROXYL. They prepared by conjugating poly(carboxylate ester) (PCE) with poly(ethylene glycol) (mPEG
Abstract Immunotherapy, especially immune checkpoint blockade (ICB) antibody immunotherapy, has revolutionized the treatment ways of cancers and provided remarkable clinical benefits for multiple cancers. However, efficacy immunotherapy in tumors with an immune‐excluded or immune‐suppressed phenotype is dismal due to lack paucity infiltration tumor microenvironment. Herein, emerging photoimmunotherapy based on remodeling inflammatory microenvironment reported, ascribed nanoagonist‐mediated...
To develop and validate a radiomics nomogram for the preoperative prediction of lymph node (LN) metastasis in pancreatic ductal adenocarcinoma (PDAC).In this retrospective study, 225 patients with surgically resected, pathologically confirmed PDAC underwent multislice computed tomography (MSCT) between January 2014 2017. Radiomics features were extracted from arterial CT scans. The least absolute shrinkage selection operator method was used to select features. Multivariable logistic...
3028 Background: LM-302 is a novel and potent MMAE antibody-drug conjugate (ADC) targeting CLDN18.2, which highly expressed in gastric/gastroesophageal junction (GEJ), pancreatic, biliary tract cancers. Preclinical studies of have demonstrated compelling anti-tumor activity multiple CLDN18.2-positive cell-lines xenograft models. Methods: This phase 1/2 study included dose escalation expansion phase. In the phase, eligible patients received once every three weeks (0.2-2.8 mg/kg Q3W), two...
T cells targeting a KRAS mutation can induce durable tumor regression in some patients with metastatic epithelial cancer. It is unknown whether mutant that are capable of killing be identified from peripheral blood pancreatic We developed an vitro stimulation approach and HLA-A*11:01-restricted G12V-reactive CD8+ HLA-DRB1*15:01-restricted CD4+ 2 out 6 HLA-A*11:01-positive cancer whose tumors expressed G12V. The cell receptor (TCR) was isolated validated to specifically recognize the G12V8-16...
Putting pancreatic adenocarcinoma (PAAD) screening into perspective for high-risk individuals could significantly reduce cancer morbidity and mortality. Previous studies have profiled somatic mutations in PAAD. In contrast, the prevalence of PAAD predisposition genes has not been defined, especially Asian population. Using a multi-tier cohort design whole genome/exome sequencing, we create comprehensive germline mutation map 1,123 Chinese patients comparison with 11 pan-ethnic studies. For...
Pancreatic ductal adenocarcinoma (PDAC) ranks fourth on the list of cancer‐related causes death. Deregulation or dysfunction miRNAs contribute to cancer development. In this study, we found that low miR‐545 level and high RIG‐I protein in PDAC tissues were both correlated with survival rate. MiR‐545 up‐regulation inhibited cell lines growth vice versa. 3′UTR was targeted by miR‐545. Thus concluded levels promote tumor cells growth, is associated reduced patients. exerts its effects directly...
Endoscopic ultrasound-guided fine-needle aspiration is associated with the accurate determination of tumor grade. However, because it an invasive procedure there a need to explore alternative noninvasive procedures.To develop and validate noncontrast radiomics model for preoperative prediction nonfunctional pancreatic neuroendocrine (NF-pNET) grade (G).Retrospective, single-center study.Patients pathologically confirmed PNETs (139) were included.3T/breath-hold single-shot fast-spin echo T2...