A5100621122- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Bone and Dental Protein Studies
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Mesenchymal stem cell research
- Cancer, Hypoxia, and Metabolism
- Pancreatitis Pathology and Treatment
- HER2/EGFR in Cancer Research
- Lung Cancer Research Studies
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Colorectal Cancer Treatments and Studies
- RNA modifications and cancer
- Analytical Chemistry and Chromatography
- Lung Cancer Diagnosis and Treatment
- Pesticide Residue Analysis and Safety
- Cancer Treatment and Pharmacology
- Parkinson's Disease Mechanisms and Treatments
- DNA Repair Mechanisms
- Air Quality and Health Impacts
- Ovarian cancer diagnosis and treatment
- Cancer Cells and Metastasis
Changhai Hospital
2008-2025
Second Military Medical University
2008-2025
Earth System Science Interdisciplinary Center
2025
University of Maryland, College Park
2025
Shanghai Ocean University
2024
Shimadzu (China)
2022-2024
Capital Medical University
2020-2024
Qilu University of Technology
2024
Shandong Academy of Sciences
2024
Nanchang University
2021-2023
Abstract The association between ambient ozone (O 3 ) and acute myocardial infarction (AMI) onset is unclear, particularly for younger patients AMI subtypes. This study examined the short‐term of O with in aged 18–55 years explored differences by subtypes patient characteristics. We analyzed 2,322 admitted to 103 US hospitals (2008–2012). Daily maximum 8‐hr concentrations estimated using a spatiotemporal deep learning approach were assigned participants' home addresses. used time‐stratified...
ABSTRACT Our previous studies have shown that the HECT E3 ubiquitin ligase NEDD4 interacts with LC3 and is required for starvation rapamycin-induced activation of autophagy. Here, we report directly binds to SQSTM1 via its domain polyubiquitylates SQSTM1. This ubiquitylation through K63 conjugation not involved in proteasomal degradation. Mutational analysis indicates ubiquitylates PB1 Depletion or overexpression ligase-defective mutant induced accumulation aberrant enlarged SQSTM1-positive...
EGFR is the cell-surface receptor. Its overexpression or overactivity has been associated with a number of cancers, including breast, lung, ovarian, and anal cancers. Many therapeutic approaches are aimed at EGFR. A series 2, 7-diamino-thiazolo [4,5-d] pyrimidine analogues among most highly potent selective inhibitors described to date. For in-depth investigation into structural chemical features responsible for binding recognition mechanism concerned, as well exploring pocket these...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human cancers. Several studies have reported that carbohydrate antigen 19-9 (CA19-9) level a useful marker for predicting prognosis PDAC after resection. However, cutoff value CA19-9 used to predict varied among these reports. The aims this study were evaluate whether serum significant predictor survival and determine optimal prognosis.A total 120 consecutive patients who underwent surgery potentially resectable primary...
Parkinson's disease (PD) is a common neurodegenerative with limited treatment and no cure, hence, broadening PD drug spectrum of great significance. At present, engineered microorganisms are attracting increasing attention. In this study, we constructed an strain
TBX1 is a member of the T-box family transcription factors characterized by conserved DNA binding domain termed T-box. has been reported to be downregulated in mouse skin tumors and considered negative regulator tumor cell growth mice. However, its role exact mechanism human cancers, including thyroid cancer, remain totally unknown.Quantitative reverse polymerase chain reaction Western blot assays were performed evaluate expression investigated genes. Methylation-specific pyrosequencing used...
Putting pancreatic adenocarcinoma (PAAD) screening into perspective for high-risk individuals could significantly reduce cancer morbidity and mortality. Previous studies have profiled somatic mutations in PAAD. In contrast, the prevalence of PAAD predisposition genes has not been defined, especially Asian population. Using a multi-tier cohort design whole genome/exome sequencing, we create comprehensive germline mutation map 1,123 Chinese patients comparison with 11 pan-ethnic studies. For...
The short-term influence of particles with an aerodynamic diameter ≤2.5 μm (PM2.5) and its individual elements on hospital costs, the length stay (LOS), admissions caused by type 2 diabetes remains unclear. A generalized additive model (GAM) quasi-Poisson distribution was utilized to assess association pollutants mixtures. For every 10 μg/m3 rise in PM2.5 a per-SD increase NH4+at lag0, increased 0.93% (95% CI: 0.68, 1.19) 2.81% 2.20, 3.42); costs rose 24.58 thousands CNY 5.95, 43.22) 77.06...
GDF11 restrains tumor growth by promoting apoptosis in pancreatic cancer Yanzhe Liu,1,* Lijuan Shao,2,* Kuang Chen,1 Zizheng Wang,1 Jin Wei Jing,3 Minggen Hu1 1Department of Hepatobiliary and Pancreatic Surgical Oncology, Chinese PLA General Hospital, Beijing, People's Republic China; 2Translational Medicine Collaborative Innovation Center, The Second Clinical Medical College (Shenzhen Hospital), Jinan University, Shenzhen, 3Department Surgery, Changhai Military Shanghai, China *These...
Objective: Mitochondrial imbalance of division and fusion will lead to uncontrolled cell growth.This study investigated the effects mitochondrial dynamics regulated by dynamin-related protein 1 (Drp1) on invasion metastasis lung cancer cells at cellular level.Methods: Lentivirus-mediated RNAi gene overexpression vectors containing shDrp1 Lv-Drp1 were transfected into adenocarcinoma lines 95D A549, respectively.An MTT assay was used assess viability a clone evaluate tumorigenic ability...
Aims: This study aimed to investigate the expression of EphA7 in human laryngeal squamous cell carcinoma (LSCC) tissues and disclose potential roles molecular mechanisms LSCC. Methods: In present study, we examined its function mechanism levels were investigated by quantitative real-time PCR (qRT-PCR), western blotting, immunohistochemistry a panel 35 LSCC patient cases. To cancer, employed siRNA knockdown line Hep-2 AMC-HN-8. Subsequently, MTT, TUNEL, qRT-PCR, blotting performed on...
Pancreatic body and tail carcinoma (PBTC) is an aggressive disease with a low resectability rate. Celiac axis infiltration usually contraindicates resection. Extended distal pancreatectomy combined en bloc celiac resection (DP-CAR, also named Appleby operation) was described as new concept for the curative treatment of these tumors. The aim this study to analyze results DP-CAR in PBTC.Analyze by summarizing 24 cases PBTC during October 2005 August 2010 pancreatic surgery our hospital...
Summary Impaired wound closure is an increasingly crucial clinical challenge. Recently, healing has shifted towards innovative treatments that exploit nanotechnology, biomaterials, biologics and phototherapy. Here, we constructed engineered MG1363‐pMG36e‐mCXCL12 strain with pMG36e plasmid encoding stromal cell‐derived factor 1α (named CXCL12) evaluated the synergistic effects of light‐emitting diode (LED) yellow light on scald wounds in mice. The results indicated combined treatment LED...
N-myc downstream-regulated gene-1 (NDRG1) has been identified as a protein involved in the differentiation of epithelial cells. As newly metastasis suppressor gene, whether it contributes to carcinogenesis breast cancer is still unknown. This study aimed clarify possible role NDRG1 for carcinogenesis, and further investigate its clinicopathological significance invasive cancer. We examined expression normal epithelium (n = 35), usual ductal hyperplasia 22), atypical 33), lobular 8),...
Although aberrant DNA methyltransferase 3a (DNMT3a) expression is important to the tumorigenesis of pancreatic ductal adenocarcinoma (PDAC), role DNMT3a in PDAC prognosis not clarified yet due limited studies and lacking underlying molecular mechanism.The was examined by immunohistochemistry tissues. Gene profiles assays were conducted explore impact on biological processes signal pathways. Cell cycle apoptosis measured flow cytometry. Western blotting real-time qPCR used protein mRNA...
Metastasis tumor antigen 1 (MTA1), a novel candidate metastasis-associated gene, is known to increase the migration and invasion of various cells in vitro. It also plays an important role tumorigenesis aggressiveness breast cancer. Estrogen receptor alpha (ERα) etiology cancer has been widely accepted as prognostic marker for response predictor endocrine therapy. The ERα gene methylation linked lack expression aim study assess correlation between MTA1 further investigate whether repressed...
The ataxia-telangiectasia-mutated (ATM) and rad3-related (ATR) checkpoint pathway plays an essential role in modulating cellular responses to replication stress DNA damage maintain genomic stability. In various tumors, cancer cells have increased dependence on ATR signaling for survival, making a promising target therapy. inhibitors sensitize multiple tumor cell types radiation DNA-damaging agents, but application of inhibitor alone shows limited efficacy. the present study, we investigated...